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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 219.00 to 220.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.122000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 179.00 °F. TCC ( 81.50 °C. ) (est)
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| logP (o/w): | -0.839 (est) |
| Soluble in: |
| | alcohol | | | water, 1.00E+04 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for protoanemonin usage levels up to: | | | not for fragrance use.
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| Recommendation for protoanemonin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2(5H)- | furanone, 5-methylene- | | 5- | methylene furan-2(5H)-one | | 5- | methylene-2(5H)-furanone | | 5- | methylenefuran-2(5H)-one | | 5- | methylidenefuran-2-one |
Articles:
| PubMed: | Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells. |
| PubMed: | Comprehensive study of the phenolics and saponins from Helleborus niger L. Leaves and stems by liquid chromatography/tandem mass spectrometry. |
| PubMed: | New branches in the degradation pathway of monochlorocatechols by Aspergillus nidulans: a metabolomics analysis. |
| PubMed: | Wild food plants used by the Tibetans of Gongba Valley (Zhouqu county, Gansu, China). |
| PubMed: | Presentation of three cases with phyto contact dermatitis caused by Ranunculus and Anthemis genera. |
| PubMed: | Feasibility study of nonclinical safety assessments on homeopathic preparations using the example of protoanemonin in Pulsatilla pratensis L. |
| PubMed: | Protoanemonin content variation between Clematis spp.: leaf, stem and root. |
| PubMed: | Acid-mediated coupling of γ-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones. |
| PubMed: | Diastereoselective access to polyoxygenated polycyclic spirolactones through a rhodium-catalyzed [3+2] cycloaddition reaction: experimental and theoretical studies. |
| PubMed: | Too low to kill: concentration of the secondary metabolite ranunculin in buttercup pollen does not affect bee larval survival. |
| PubMed: | Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response. |
| PubMed: | Consortia modulation of the stress response: proteomic analysis of single strain versus mixed culture. |
| PubMed: | Novel metal-binding site of Pseudomonas reinekei MT1 trans-dienelactone hydrolase. |
| PubMed: | Characterization of a gene cluster involved in 4-chlorocatechol degradation by Pseudomonas reinekei MT1. |
| PubMed: | Irritant contact dermatitis from plants. |
| PubMed: | Pseudomonas aeruginosa strain RW41 mineralizes 4-chlorobenzenesulfonate, the major polar by-product from DDT manufacturing. |
| PubMed: | 25 years of natural product R&D with New South Wales agriculture. |
| PubMed: | Phytodermatitis caused by Ceratocephalus falcatus (Ranunculacea). |
| PubMed: | 2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release. |
| PubMed: | The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations. |
| PubMed: | Chemical composition of anther volatiles in Ranunculaceae: genera-specific profiles in Anemone, Aquilegia, Caltha, Pulsatilla, Ranunculus, and Trollius species. |
| PubMed: | New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1. |
| PubMed: | [Poisonous and less poisonous plants. 52]. |
| PubMed: | Radiation-activated nuclease activity of o,o'-Diphenyleneiodonium cations (DPI): a reductively initiated chain reaction involving the C1' chemistry. |
| PubMed: | Formation of protoanemonin from 2-chloro-cis,cis-muconate by the combined action of muconate cycloisomerase and muconolactone isomerase. |
| PubMed: | Polychlorinated biphenyl-degrading microbial communities in soils and sediments. |
| PubMed: | Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A. |
| PubMed: | Interaction of Sphingomonas and Pseudomonas strains in the degradation of chlorinated dibenzofurans. |
| PubMed: | Towards elucidation of microbial community metabolic pathways: unravelling the network of carbon sharing in a pollutant-degrading bacterial consortium by immunocapture and isotopic ratio mass spectrometry. |
| PubMed: | Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. |
| PubMed: | Mechanisms of DNA damage by chromium(V) carcinogens. |
| PubMed: | Detoxification of protoanemonin by dienelactone hydrolase. |
| PubMed: | PROTOANEMONIN-INDUCED CYTOTOXIC EFFECTS IN EUGLENA GRACILIS |
| PubMed: | [More and less toxic plants]. |
| PubMed: | Evidence that Formation of Protoanemonin from Metabolites of 4-Chlorobiphenyl Degradation Negatively Affects the Survival of 4-Chlorobiphenyl-Cometabolizing Microorganisms. |
| PubMed: | From xenobiotic to antibiotic, formation of protoanemonin from 4-chlorocatechol by enzymes of the 3-oxoadipate pathway. |
| PubMed: | DNA cleavage by Cu(II)-desferal: identification of C1'-hydroxylation as the initial event for DNA damage. |
| PubMed: | Suspected buttercup (Ranunculus bulbosus) toxicosis with secondary photosensitization in a Charolais heifer. |
| PubMed: | Mechanism of DNA cleavage by cationic manganese porphyrins: hydroxylations at the 1'-carbon and 5'-carbon atoms of deoxyriboses as initial damages. |
| PubMed: | [Antibacterial activity of vapors of protoanemonine]. |
| PubMed: | In vitro activity of protoanemonin, an antifungal agent. |
| PubMed: | Ultrastructural alterations in Epidermophyton floccosum and Trichophyton mentagrophytes exposed in vitro to protoanemonin. |
| PubMed: | Electron microscopy of Microsporum cookei after 'in vitro' treatment with protoanemonin: a combined SEM and TEM study. |
| PubMed: | [1'-carbon hydroxylation of deoxyribose as the mechanism of cleavage of poly(dA) by manganese porphyrin combined with potassium monopersulfate]. |
| PubMed: | Pharmacologic effects of lactones isolated from Pulsatilla alpina subsp. apiifolia. |
| PubMed: | Antimicrobial activity of protoanemonin, a lactone from ranunculaceous plants. |
| PubMed: | Separation and quantitation of protoanemonin in ranunculaceae by normal- and reversed-phase HPLC. |
| PubMed: | Counter-irritant and other medicinal uses of plants in Ranunculaceae by native peoples in British Columbia and neighbouring areas. |
| PubMed: | Native American medicinal plants. Anemonin from the horse stimulant Clematis hirsutissima. |
| PubMed: | Protoanemonin, an antimutagen isolated from plants. |
| PubMed: | External antirheumatic and antineuralgic herbal remedies in the traditional medicine of north-eastern Italy. |
| PubMed: | Spectrophotometric determination of protoanemonin, anemonin and ranunculin in Ranunculus sceleratus L. |
| PubMed: | [Antibiotic activity of protoanemonin in extracts of some lowland species of Ranunculus L]. |
| PubMed: | [On antibacterial, antiviral, antitoxic and cytopathogenic properties of protoanemonin and anemonin]. |
| PubMed: | [Thiol substances and the cytopharmacological effects of protoanemonin on karyokinesis. Experimental research]. |
| PubMed: | [A new synthesis of protoanemonin and of phenylcoumalin. On the knowledge of acetylenecarboxylic acids. XII]. |
| PubMed: | [Preservation of properties of protoanemonin in various solvents]. |
| PubMed: | [Determination of protoanemonin]. |
| PubMed: | Disseminated coccidioidomycosis; treatment with protoanemonin. |
| PubMed: | Inhibition of Plant Growth by Protoanemonin and Coumarin, and Its Prevention by Bal. |
| PubMed: | Inhibition of plant growth by protoanemonin and coumarin and its prevention by BAL. |
| PubMed: | Cytological effects of protoanemonin on the root tip of Zea Mays. |
| PubMed: | Protoanemonin as a Mitotic Inhibitor. |
| PubMed: | The inhibition of pyruvic oxidase by protoanemonin. |
| PubMed: | Range of antibiotic activity of protoanemonin. |
| PubMed: | A synthesis of protoanemonin; the tautomerism of acetylacrylic acid and of penicillic acid. |
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