celastrol, 34157-83-0

Articles:

PubMed:	Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats.
PubMed:	Caloric restriction and exercise "mimetics'': Ready for prime time?
PubMed:	Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
PubMed:	Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment.
PubMed:	Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol.
PubMed:	Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation.
PubMed:	Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer.
PubMed:	Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.
PubMed:	Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells.
PubMed:	The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice.
PubMed:	Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
PubMed:	Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells.
PubMed:	Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid chromatography-triple quadrupole mass spectrometry.
PubMed:	Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
PubMed:	Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products.
PubMed:	Expression profile of heat shock response factors during hookworm larval activation and parasitic development.
PubMed:	Cloning and functional characterization of an isopentenyl diphosphate isomerase gene from Tripterygium wilfordii.
PubMed:	Hsp90 Activity Modulation by Plant Secondary Metabolites.
PubMed:	[Effect of celastrol in inhibiting metastasis of lung cancer cells by influencing Akt signaling pathway and expressing integrins].
PubMed:	Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells.
PubMed:	Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.
PubMed:	Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs.
PubMed:	Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice.
PubMed:	Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner.
PubMed:	[Anti-metastasis of celastrol on esophageal cancer cells and its mechanism].
PubMed:	Celastrol identified as a leptin sensitizer and potential novel treatment for obesity.
PubMed:	Treatment of obesity with celastrol.
PubMed:	Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
PubMed:	Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells.
PubMed:	Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation.
PubMed:	Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation.
PubMed:	Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents.
PubMed:	Effect of celastrol on growth inhibition of prostate cancer cells through the regulation of hERG channel in vitro.
PubMed:	Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy.
PubMed:	Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways.
PubMed:	Celastrol supports survival of retinal ganglion cells injured by optic nerve crush.
PubMed:	Design and synthesis of celastrol derivatives as anticancer agents.
PubMed:	Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.
PubMed:	Effects of Plants and Isolates of Celastraceae Family on Cancer Pathways.
PubMed:	Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.
PubMed:	Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems.
PubMed:	Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.
PubMed:	Celastrol induces mitochondria-mediated apoptosis in hepatocellular carcinoma Bel-7402 cells.
PubMed:	Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study.
PubMed:	Celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats.
PubMed:	Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264.7.
PubMed:	Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-κB pathways.
PubMed:	Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.
PubMed:	Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.
PubMed:	Redox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agents.
PubMed:	ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway.
PubMed:	Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.
PubMed:	Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9.
PubMed:	Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism.
PubMed:	Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.
PubMed:	Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.
PubMed:	Characterization of eight terpenoids from tissue cultures of the Chinese herbal plant, Tripterygium wilfordii, by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
PubMed:	Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats.
PubMed:	Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells.
PubMed:	Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.
PubMed:	miR-326-histone deacetylase-3 feedback loop regulates the invasion and tumorigenic and angiogenic response to anti-cancer drugs.
PubMed:	Celastrol may have an anti-atherosclerosis effect in a rabbit experimental carotid atherosclerosis model.
PubMed:	Celastrol inhibits lung infiltration in differential syndrome animal models by reducing TNF-α and ICAM-1 levels while preserving differentiation in ATRA-induced acute promyelocytic leukemia cells.
PubMed:	Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2.
PubMed:	Stemness is Derived from Thyroid Cancer Cells.
PubMed:	Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.
PubMed:	Accumulation of heme oxygenase-1 (HSP32) in Xenopus laevis A6 kidney epithelial cells treated with sodium arsenite, cadmium chloride or proteasomal inhibitors.
PubMed:	Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells.
PubMed:	Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts.
PubMed:	Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.
PubMed:	Design, synthesis and biological evaluation of C6-modified celastrol derivatives as potential antitumor agents.
PubMed:	[Protective effect of celastrol on allergic rhinitis in rats].
PubMed:	Celastrol enhanced the anticancer effect of lapatinib in human hepatocellular carcinoma cells in vitro.
PubMed:	The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype.
PubMed:	Solid self-microemulsifying dispersible tablets of celastrol: formulation development, charaterization and bioavailability evaluation.
PubMed:	Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
PubMed:	Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.
PubMed:	Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.
PubMed:	The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
PubMed:	Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.
PubMed:	Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.
PubMed:	NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis.
PubMed:	Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.
PubMed:	Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase.
PubMed:	Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol.
PubMed:	Celastrol enhances cell viability and inhibits amyloid-β production induced by lipopolysaccharide in vitro.
PubMed:	Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy.
PubMed:	Celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells.
PubMed:	Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
PubMed:	Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells.
PubMed:	Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo.
PubMed:	Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells.
PubMed:	A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells.
PubMed:	Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo.
PubMed:	Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway.
PubMed:	Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.
PubMed:	Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.
PubMed:	Plants and phytochemicals for Huntington's disease.
PubMed:	Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.
PubMed:	IP-FCM platform detects the existence and regulator-caused dissociation of components in naturally assembled HSP90 complex.
PubMed:	Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.
PubMed:	Celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation.
PubMed:	Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.
PubMed:	Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity.
PubMed:	[Chemical constituents of roots of Celastrus orbiculatus].
PubMed:	Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.
PubMed:	Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?
PubMed:	Expression and purification of recombinant NRL-Hsp90α and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening.
PubMed:	Testing agents for prevention or reversal of type 1 diabetes in rodents.
PubMed:	miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells.
PubMed:	Celastrol protects kidney against ischemia-reperfusion-induced injury in rats.
PubMed:	Natural friedelanes.
PubMed:	Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma.
PubMed:	Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix metalloproteinase-9 expression.
PubMed:	Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
PubMed:	ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network.
PubMed:	Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.
PubMed:	Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.
PubMed:	Celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress.
PubMed:	Celastrol and attenuation of tumor growth in systemic malignancies: a clinical perspective.
PubMed:	Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis.
PubMed:	Regiochemistry discoveries in the use of isoxazole as a handle for the rapid construction of an all-carbon macrocyclic precursor in the synthetic studies of celastrol.
PubMed:	Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells.
PubMed:	Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity.
PubMed:	Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo.
PubMed:	Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice.
PubMed:	Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy.
PubMed:	Heterogeneity in the properties of NEFL mutants causing Charcot-Marie-Tooth disease results in differential effects on neurofilament assembly and susceptibility to intervention by the chaperone-inducer, celastrol.
PubMed:	Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
PubMed:	Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer.
PubMed:	Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).
PubMed:	Proteasome inhibition protects human peripheral blood mononuclear cells from radiation-induced oxidative stress.
PubMed:	Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
PubMed:	Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
PubMed:	The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
PubMed:	Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.
PubMed:	Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway.
PubMed:	AFM studied the effect of celastrol on β1 integrin-mediated HUVEC adhesion and migration.
PubMed:	Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling.
PubMed:	Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.
PubMed:	Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling.
PubMed:	Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats.
PubMed:	Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
PubMed:	Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells.
PubMed:	The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.
PubMed:	Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells.
PubMed:	Induction of heat shock proteins in cerebral cortical cultures by celastrol.
PubMed:	Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.
PubMed:	Optimized preparation of celastrol-loaded polymeric nanomicelles using rotatable central composite design and response surface methodology.
PubMed:	Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells.
PubMed:	Strong inhibition of celastrol towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction.
PubMed:	[Expression, purification of proteasome subunit PSMB1 and application in screening of possible proteasome inhibitors].
PubMed:	Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.
PubMed:	Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.
PubMed:	Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model.
PubMed:	TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.
PubMed:	Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.
PubMed:	Protective effect of celastrol in rat cerebral ischemia model: down-regulating p-JNK, p-c-Jun and NF-κB.
PubMed:	Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response.
PubMed:	Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk.
PubMed:	Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice.
PubMed:	Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers.
PubMed:	Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats.
PubMed:	Effective treatment of rat adjuvant-induced arthritis by celastrol.
PubMed:	Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets.
PubMed:	Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
PubMed:	Preparation, characterization, and assessment of the antiglioma effects of liposomal celastrol.
PubMed:	Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.
PubMed:	Terpenoids from root bark of Celastrus orbiculatus.
PubMed:	Formulation and evaluation of celastrol-loaded liposomes.
PubMed:	Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol.
PubMed:	Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
PubMed:	Quantitative proteomics reveals cellular targets of celastrol.
PubMed:	Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells.
PubMed:	Ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction coupled with high performance liquid chromatography for sensitive determination of trace celastrol in urine.
PubMed:	Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity.
PubMed:	Diarylheptanoids from the seeds of Alpinia katsumadai as heat shock factor 1 inducers.
PubMed:	Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90.
PubMed:	Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.
PubMed:	Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
PubMed:	Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway.
PubMed:	Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.
PubMed:	Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.
PubMed:	Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.
PubMed:	The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
PubMed:	Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells.
PubMed:	New strategy of photodynamic treatment of TiO2 nanofibers combined with celastrol for HepG2 proliferation in vitro.
PubMed:	Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules.
PubMed:	Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.
PubMed:	Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
PubMed:	NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
PubMed:	Gambogic acid, a natural product inhibitor of Hsp90.
PubMed:	Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.
PubMed:	[Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line].
PubMed:	Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells.
PubMed:	Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses.
PubMed:	Tunable physiologic interactions of adhesion molecules for inflamed cell-selective drug delivery.
PubMed:	Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90.
PubMed:	Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway.
PubMed:	Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
PubMed:	Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.
PubMed:	Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.
PubMed:	Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
PubMed:	Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.
PubMed:	A systematic protocol for the characterization of Hsp90 modulators.
PubMed:	Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
PubMed:	PP2A mediated AMPK inhibition promotes HSP70 expression in heat shock response.
PubMed:	Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio).
PubMed:	Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α.
PubMed:	Celastrol enhances AAV1-mediated gene expression in mice adipose tissues.
PubMed:	Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
PubMed:	Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
PubMed:	[Celastrol down-regulates expression of P-Akt and cyclin D1 in HL-60 cells and induces apoptosis].
PubMed:	Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice.
PubMed:	A cellular viability assay to monitor drug toxicity.
PubMed:	Targeting apoptosis pathways in cancer by Chinese medicine.
PubMed:	Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.
PubMed:	Celastrol: a new therapeutic potential of traditional Chinese medicine.
PubMed:	Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells.
PubMed:	Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L.
PubMed:	Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.
PubMed:	Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.
PubMed:	Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway.
PubMed:	Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.
PubMed:	Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1.
PubMed:	HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.
PubMed:	Celastrol suppresses morphological and transcriptional responses in microglial cells upon stimulation with double-stranded RNA.
PubMed:	Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro.
PubMed:	Celastrol: Molecular targets of Thunder God Vine.
PubMed:	Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.
PubMed:	Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.
PubMed:	SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.
PubMed:	Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
PubMed:	Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
PubMed:	Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.
PubMed:	Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.
PubMed:	Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.
PubMed:	Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells.
PubMed:	Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol.
PubMed:	Celastrol causes apoptosis and cell cycle arrest in rat glioma cells.
PubMed:	Characterization of celastrol to inhibit hsp90 and cdc37 interaction.
PubMed:	Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation.
PubMed:	The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma.
PubMed:	Triterpenoids as new promising anticancer drugs.
PubMed:	Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease.
PubMed:	Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study.
PubMed:	MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules.
PubMed:	Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.
PubMed:	Celastrol, a triterpene extracted from Tripterygium wilfordii Hook F, inhibits platelet activation.
PubMed:	Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.
PubMed:	Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii.
PubMed:	Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer.
PubMed:	Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
PubMed:	Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
PubMed:	CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug.
PubMed:	Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects.
PubMed:	Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
PubMed:	Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
PubMed:	Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.
PubMed:	Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression.
PubMed:	Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
PubMed:	High-performance liquid chromatography spectrometric analysis of tripterin in rat plasma.
PubMed:	A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells.
PubMed:	Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.
PubMed:	Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.
PubMed:	Antimitotic quinoid triterpenes from Maytenus chuchuhuasca.
PubMed:	Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells.
PubMed:	Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.
PubMed:	Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response.
PubMed:	Induction of heat shock proteins in differentiated human and rodent neurons by celastrol.
PubMed:	Molecular understanding and modern application of traditional medicines: triumphs and trials.
PubMed:	Heat shock proteins and protection of the nervous system.
PubMed:	Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
PubMed:	The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry".
PubMed:	Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
PubMed:	Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.
PubMed:	Naturally occurring NF-kappaB inhibitors.
PubMed:	Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis.
PubMed:	Neuroprotective agents for clinical trials in ALS: a systematic assessment.
PubMed:	Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
PubMed:	Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.
PubMed:	Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.
PubMed:	Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.
PubMed:	Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus.
PubMed:	Celastrols as inducers of the heat shock response and cytoprotection.
PubMed:	Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies.
PubMed:	Preparative isolation and purification of celastrol from Celastrus orbiculatus Thunb. by a new counter-current chromatography method with an upright coil planet centrifuge.
PubMed:	Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
PubMed:	[Celastrol in the inhibition of neovascularization].
PubMed:	Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
PubMed:	Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction.
PubMed:	[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].
PubMed:	Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography.
PubMed:	Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.
PubMed:	Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.
PubMed:	Immunomodulating components from chinese medicines.
PubMed:	Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.
PubMed:	[In vitro inhibition of celastrol on spermatozoa fertilization ability of guinea pig].
PubMed:	Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation.
PubMed:	Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.
PubMed:	Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants.
PubMed:	The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.
PubMed:	The cathedulin alkaloids.