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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 594.29 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 596.00 °F. TCC ( 313.20 °C. ) (est)
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| logP (o/w): | 3.201 (est) |
| Soluble in: |
| | water, 0.9604 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for gedunin usage levels up to: | | | not for fragrance use.
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| Recommendation for gedunin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
Articles:
| PubMed: | Stimulation of erythrocyte cell membrane scrambling by gedunin. |
| PubMed: | Evaluation of a fluorescence-based method for antibabesial drug screening. |
| PubMed: | Review on pharmacological and toxicologyical effects of oleum azadirachti oil. |
| PubMed: | Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. |
| PubMed: | The therapeutic properties of Carapa guianensis. |
| PubMed: | Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis. |
| PubMed: | Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation. |
| PubMed: | Antiplasmodial activity of the andiroba (Carapa guianensis Aubl., Meliaceae) oil and its limonoid-rich fraction. |
| PubMed: | Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum. |
| PubMed: | Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT-dependent Extraction of Ceramides from the Endoplasmic Reticulum. |
| PubMed: | The limonoids and their antitobacco mosaic virus (TMV) activities from Munronia unifoliolata Oliv. |
| PubMed: | Querying genomic databases: refining the connectivity map. |
| PubMed: | The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-κB and MAPK pathways. |
| PubMed: | Effect of triterpenoids and limonoids isolated from Cabralea canjerana and Carapa guianensis (Meliaceae) against Spodoptera frugiperda (J. E. Smith). |
| PubMed: | Antimalarial activity in Xylocarpus granatum (Koen). |
| PubMed: | Rings D-seco and B,D-seco tetranortriterpenoids from root bark of Entandrophragma angolense. |
| PubMed: | Limonoids from seeds of Thai Xylocarpus moluccensis. |
| PubMed: | Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. |
| PubMed: | Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host. |
| PubMed: | Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). |
| PubMed: | Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line. |
| PubMed: | A systematic protocol for the characterization of Hsp90 modulators. |
| PubMed: | Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. |
| PubMed: | Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica. |
| PubMed: | Limonoids from the leaves of Cipadessa baccifera. |
| PubMed: | Deoxygedunin, a natural product with potent neurotrophic activity in mice. |
| PubMed: | 7-Deacetyl-gedunin. |
| PubMed: | Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. |
| PubMed: | Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation. |
| PubMed: | Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum. |
| PubMed: | Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury. |
| PubMed: | Effects of limonoids from Cipadessa fruticosa on fall armyworm. |
| PubMed: | Susceptibility of Aedes aegypti and Culex quinquefasciatus Larvae to gedunin-related limonoids. |
| PubMed: | 6α-Acetoxy-gedunin. |
| PubMed: | Isolation of limonoids from seeds of Carapa guianensis Aublet (Meliaceae) by high-speed countercurrent chromatography. |
| PubMed: | Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. |
| PubMed: | Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). |
| PubMed: | Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. |
| PubMed: | Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. |
| PubMed: | Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. |
| PubMed: | The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. |
| PubMed: | Hydroxylated gedunin derivatives from Cedrela sinensis. |
| PubMed: | Inhibition of allergen-induced eosinophil recruitment by natural tetranortriterpenoids is mediated by the suppression of IL-5, CCL11/eotaxin and NFkappaB activation. |
| PubMed: | The toxicity and behavioural effects of neem limonoids on Cnaphalocrocis medinalis (Guenée), the rice leaffolder. |
| PubMed: | Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae). |
| PubMed: | Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor. |
| PubMed: | Effects of neem limonoids on the malaria vector Anopheles stephensi Liston (Diptera: Culicidae). |
| PubMed: | Insect growth inhibition by tocotrienols and hydroquinones from Roldana barba-johannis. |
| PubMed: | Antioxidant and insect growth regulatory activities of stilbenes and extracts from Yucca periculosa. |
| PubMed: | 6beta-hydroxygedunin from Azadirachta indica. Its potentiation effects with some non-azadirachtin limonoids in neem against lepidopteran larvae. |
| PubMed: | Traditionally-used antimalarials from the Meliaceae. |
| PubMed: | Three new tetranortriterpenoids from neem seed oil. |
| PubMed: | Acetylcholinesterase and insect growth inhibitory activities of Gutierrezia microcephala on fall armyworm Spodoptera frugiperda J.E. Smith. |
| PubMed: | Growth inhibitory effects on fall armyworm Spodoptera frugiperda of some limonoids isolated from Cedrela spp. (Meliaceae). |
| PubMed: | Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi. |
| PubMed: | In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). |
| PubMed: | Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. |
| PubMed: | Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin. |
| PubMed: | Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica. |
| PubMed: | Potential antimalarial candidates from African plants: and in vitro approach using Plasmodium falciparum. |
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