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Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white solid (est) |
| Assay: | 99.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 183.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 341.00 to 342.00 °C. @ 760.00 mm Hg
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| Acid Value: | 2.00 max. KOH/g
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| Flash Point: | 321.00 °F. TCC ( 160.56 °C. )
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| logP (o/w): | 2.793 (est) |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 22.61 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
Odor Description: at 100.00 %. | fruity |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | flavoring agents |
| Recommendation for benzoyl anthranilic acid usage levels up to: | | | not for fragrance use.
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| Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.20 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 2.00 (μg/capita/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 22 |
| Click here to view publication 22 |
| | average usual ppm | average maximum ppm |
| baked goods: | 50.00000 | 100.00000 |
| beverages(nonalcoholic): | 20.00000 | 40.00000 |
| beverages(alcoholic): | 30.00000 | 50.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | 500.00000 | 1000.00000 |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 50.00000 | 1000.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | 10.00000 | 20.00000 |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 50.00000 | 100.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | benzamidobenzoic acid | | o- | benzamidobenzoic acid | | | benzoic acid, 2-(benzoylamino)- | | 2-( | benzoyl amino) benzoic acid | | 2- | benzoyl aminobenzoic acid | | N- | benzoyl-2-carboxybenzanilide | | 2- | benzoylamino-benzoic acid | | 2-( | benzoylamino)benzoic acid | | 2- | benzoylaminobenzoic acid | | N- | benzoylanthranilic acid | | 2'- | carboxybenzanilide | | N-(2- | carboxyphenyl) benzamide | | N-(2- | carboxyphenyl)benzamide | | | dianthramid B | | 2-[( | phenylcarbonyl)amino]benzoic acid | | 2-( | phenylcarbonylamino)benzoic acid |
Articles:
| Info: | anthranilate derivatives |
| PubMed: | N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. |
| PubMed: | Anaerobic degradation of 2-aminobenzoic acid (anthranilic acid) via benzoyl-coenzyme A (CoA) and cyclohex-1-enecarboxyl-CoA in a denitrifying bacterium. |
| PubMed: | The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents. |
| PubMed: | Production of tranilast [N-(3',4'-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae. |
| PubMed: | NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. |
| PubMed: | Substituent effects on energetics of peptide-carboxylate hydrogen bonds as studied by 1H NMR spectroscopy: implications for enzyme catalysis. |
| PubMed: | Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli. |
| PubMed: | Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs. |
| PubMed: | Chromophenazines from the terrestrial Streptomyces sp. Ank 315. |
| PubMed: | Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase. |
| PubMed: | DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats. |
| PubMed: | Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators. |
| PubMed: | A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. |
| PubMed: | Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents. |
| PubMed: | Synthesis and biological activity of certain derivatives of 2,4-dioxo-1,2,3,4-tetrahydroquinazoline. Part 2. |
| PubMed: | Disubstituted 4(3H) quinazolones: a novel class of antitumor agents. |
| PubMed: | Synthesis, Structure Activity Relationship Studies and Pharmacological Evaluation of 2-Phenyl-3-(Substituted Phenyl)-3H-Quinazolin-4-ones as Serotonin 5-HT(2) Antagonists. |
| PubMed: | The biosynthesis and regulation of biosynthesis of Concord grape fruit esters, including 'foxy' methylanthranilate. |
| PubMed: | [Studies of sulfhemoglobin formation by various drugs (3) (author's transl)]. |
| PubMed: | The biosynthesis of phytoalexins in Dianthus caryophyllus L. cell cultures: induction of benzoyl-CoA:anthranilate N-benzoyltransferase activity. |
| PubMed: | Synthesis and biological studies of some benzopyran. |
| PubMed: | The mechanism of kynurenine hydrolysis catalyzed by kynureninase. |
| PubMed: | New aminophenoxazinones from a marine Halomonas sp.: fermentation, structure elucidation, and biological activity. |
| PubMed: | Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts. |
| PubMed: | N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent. |
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