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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 92.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 346.00 to 348.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.000111 mmHg @ 25.00 °C. (est) |
| Flash Point: | 338.00 °F. TCC ( 170.00 °C. )
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| logP (o/w): | 8.469 (est) |
| Soluble in: |
| | alcohol | | | water, 0.001334 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for 16-kaurene usage levels up to: | | | not for fragrance use.
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| Recommendation for 16-kaurene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | kaur-16-ene | | (-)- | kaur-16-ene |
Articles:
| PubMed: | Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum. |
| PubMed: | Microbial transformation of the diterpene 7-epi-foliol by Fusarium fujikuroi. |
| PubMed: | Diterpenes and phenolic compounds from Sideritis pullulans. |
| PubMed: | Two new natural products from Croton kongensis Gagnep. |
| PubMed: | Essential oil characterization of two Azorean Cryptomeria japonica populations and their biological evaluations. |
| PubMed: | [Chemical constituents from seeds of Vigna umbellata]. |
| PubMed: | Headspace, solid-phase micro-extraction, gas chromatographic-mass spectrometric analysis of terpenoids in the latex of Euphorbia species. |
| PubMed: | Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines. |
| PubMed: | Biotransformation of ent-kaur-16-ene and ent-trachylobane 7β-acetoxy derivatives by the fungus Gibberella fujikuroi (Fusarium fujikuroi). |
| PubMed: | Chemical composition and antitermitic activity against Coptotermes formosanus Shiraki of Cryptomeria japonica leaf essential oil. |
| PubMed: | Determination and potential importance of diterpene (kaur-16-ene) emitted from dominant coniferous trees in Japan. |
| PubMed: | Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of ¹H NMR and HPLC-ESI-MS. |
| PubMed: | Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark. |
| PubMed: | 15α,20β-Dihydr-oxy-6β-meth-oxy-6,7-seco-6,20-ep-oxy-1,7-olide-ent-kaur-16-ene. |
| PubMed: | 6β,15β-Diacet-oxy-1β,7β,13α-trihydr-oxy-7α,20-ep-oxy-ent-kaur-16-ene. |
| PubMed: | 1α,6β,7β,11α,15β-Penta-hydr-oxy-7α,20-ep-oxy-ent-kaur-16-ene. |
| PubMed: | 6β-Acet-oxy-1α,7β,11β,15β-tetra-hydr-oxy-7α,20-ep-oxy-ent-kaur-16-ene. |
| PubMed: | Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata. |
| PubMed: | Chemical constituents of Isodon nervosus and their cytotoxicity. |
| PubMed: | Comparison of chemical compositions and antimicrobial activities of essential oils from three conifer trees; Pinus densiflora, Cryptomeria japonica, and Chamaecyparis obtusa. |
| PubMed: | An ent-kaurane diterpenoid from Isodon japonica var. glaucocalyx. |
| PubMed: | 1α,6β,7β,14β,15β-Penta-hydr-oxy-7α,20-ep-oxy-ent-kaur-16-ene. |
| PubMed: | Antiacetylcholinesterase and antioxidant ent-Kaurene diterpenoid, melissoidesin from Isodon wightii (Bentham) H. Hara. |
| PubMed: | Diterpenoids from the roots of Suregada glomerulata. |
| PubMed: | Isolation and biological activity of new and known isolation and biological activity of new and known diterpenoids from Sideritis stricta Boiss. & Heldr. |
| PubMed: | ent-Kaurenoids from the roots of Cacalia pilgeriana. |
| PubMed: | The microbiological transformation of 7alpha-hydroxy-ent-kaur-16-ene derivatives by Gibberella fujikuroi. |
| PubMed: | Antibacterial diterpenoids from Sagittaria pygmaea. |
| PubMed: | Functional characterization of the rice kaurene synthase-like gene family. |
| PubMed: | Potential anti-allergic ent-kaurene diterpenes from the bark of Suregada multiflora. |
| PubMed: | Major volatile constituents of Annona squamosa L. bark. |
| PubMed: | Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum. |
| PubMed: | Mono and diterpene production in Escherichia coli. |
| PubMed: | The microbiological transformation of two 15beta-hydroxy-ent-kaurene diterpenes by Gibberella fujikuroi. |
| PubMed: | Composition and antimicrobial activity of the essential oils from invasive species of the Azores, Hedychium gardnerianum and Pittosporum undulatum. |
| PubMed: | On the ent-kaurene diterpenes from Sideritis athoa. |
| PubMed: | Microbial transformation of 18-hydroxy-9,13-epi-ent-pimara-7,15-diene by Gibberella fujikuroi. |
| PubMed: | Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus. |
| PubMed: | ent-Kaurene and squalene synthesis in Fusarium fujikuroi cell-free extracts. |
| PubMed: | The steam volatile oil of Wollemia nobilis and its comparison with other members of the Araucariaceae (Agathis and Araucaria). |
| PubMed: | A new diterpene glycoside from Rabdosia rubescens. |
| PubMed: | Diterpenoids from isodon eriocalyx |
| PubMed: | Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus. |
| PubMed: | Isolation of two cytotoxic diterpenes from the fern Pteris multifida. |
| PubMed: | Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp. |
| PubMed: | Biosynthesis of rice phytoalexins: identification of putative diterpene hydrocarbon precursors. |
| PubMed: | Structure Elucidation of Inflexarabdonins G and H: Two New Diterpenoids from Rabdosia inflexa. |
| PubMed: | Isolation of gibberellin precursors from heavily pigmented tissues. |
| PubMed: | ent-Kaurene Biosynthesis in Cell-Free Extracts of Excised Parts of Tall and Dwarf Pea Seedlings. |
| PubMed: | Relationship between Chloroplast Development and ent-Kaurene Biosynthesis in Peas. |
| PubMed: | Diterpene biosynthesis in maize seedlings in response to fungal infection. |
| PubMed: | Studies on the Specificity and Site of Action of alpha-Cyclopropyl-alpha-[p-methoxyphenyl]-5-pyrimidine Methyl Alcohol (Ancymidol), a Plant Growth Regulator. |
| PubMed: | Properties of the System for the Mixed Function Oxidation of Kaurene and Kaurene Derivatives in Microsomes of the Immature Seed of Marah macrocarpus: Electron Transfer Components. |
| PubMed: | Properties of the System for the Mixed Function Oxidation of Kaurene and Kaurene Derivatives in Microsomes of the Immature Seed of Marah macrocarpus: Cofactor Requirements. |
| PubMed: | Biosynthesis of natural products. Part 1. Incorporations of ent-Kaur-16-ene and ent-Kaur-16-en-15-one into enmein and oridonin. |
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