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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 368.00 to 369.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000013 mmHg @ 25.00 °C. (est) |
| Flash Point: | 309.00 °F. TCC ( 154.20 °C. ) (est)
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| logP (o/w): | 1.775 (est) |
| Soluble in: |
| | alcohol | | | water, 103.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for (S)-sencyunolide usage levels up to: | | | not for fragrance use.
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| Recommendation for (S)-sencyunolide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (S)-3- | butyl-4,5-dihydro-1(3H)-isobenzofuranone | | (3S)-3- | butyl-4,5-dihydro-3H-2-benzofuran-1-one | | (S)-3-N- | butyl-4,5-dihydrophthalide | | (S)- | senkyunolide | | (S)- | senkyunolide A |
Articles:
| PubMed: | Development of an analytical method coupling cell membrane chromatography with gas chromatography-mass spectrometry via microextraction by packed sorbent and its application in the screening of volatile active compounds in natural products. |
| PubMed: | Evaluation of the influence of sulfur fumigation on the pharmacokinetics of four active ingredients in Si Wu Tang. |
| PubMed: | The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry. |
| PubMed: | Simultaneous Determination of 10 Components in Bu-Zhong-Yi-Qi Wan by Solid Phase Extraction-High Performance Liquid Chromatography with Diode Array Detection and Evaporative Light Scattering Detection. |
| PubMed: | [Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC]. |
| PubMed: | Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS. |
| PubMed: | Multi-component analysis in sun-dried and sulfur-fumigated Angelicae Sinensis Radix by single marker quantitation and chemometric discrimination. |
| PubMed: | Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction. |
| PubMed: | Analysis of the Correlation between Commodity Grade and Quality of Angelica sinensis by Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics. |
| PubMed: | [Network pharmacology study on major active compounds of siwu decoction analogous formulae for treating primary dysmenorrhea of gynecology blood stasis syndrome]. |
| PubMed: | [A new phthalide from angelicae sinensis radix]. |
| PubMed: | Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology. |
| PubMed: | [Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design]. |
| PubMed: | A high performance liquid chromatography fingerprinting and ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry chemical profiling approach to rapidly find characteristic chemical markers for quality evaluation of dispensing granules, a case study on Chuanxiong Rhizoma. |
| PubMed: | [Preparation of ferulic acid, senkyunolide I and senkyunolide H from Ligusticum chuanxiong by preparative HPLC]. |
| PubMed: | [Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS]. |
| PubMed: | Structure elucidation of degradation products of Z-ligustilide by UPLC-QTOF-MS and NMR spectroscopy. |
| PubMed: | Simultaneous quantification of six main active constituents in Chinese Angelica by high-performance liquid chromatography with photodiode array detector. |
| PubMed: | [Chemical change of chuanxiong raw materials during storage]. |
| PubMed: | Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. |
| PubMed: | Utilization of gene expression signature for quality control of traditional Chinese medicine formula Si-Wu-Tang. |
| PubMed: | [Comparative study on pharmacokinetics of senkyunolide I after administration of simple recipe and compound recipe in rats]. |
| PubMed: | Identification of senkyunolide I metabolites in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry. |
| PubMed: | Identification of NF-κB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF. |
| PubMed: | Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography. |
| PubMed: | [Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS]. |
| PubMed: | Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang. |
| PubMed: | Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD. |
| PubMed: | [Analysis on correlation between general efficacy and chemical constituents of danggui-chuanxiong herb pair based on artificial neural network]. |
| PubMed: | [Influence of different solutions on extracting of active components in Danggui Chishao drug pair]. |
| PubMed: | Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae). |
| PubMed: | Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls. |
| PubMed: | Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint. |
| PubMed: | [Release characteristics in vitro and pharmacokinetics of da chuanxiong fang multiunit drug delivery system in rats]. |
| PubMed: | Qualitative and quantitative analysis of the major constituents in Chinese medicinal preparation Guan-Xin-Ning injection by HPLC-DAD-ESI-MS(n). |
| PubMed: | Preparative isolation and purification of senkyunolide-I, senkyunolide-H and ferulic acid from Rhizoma Chuanxiong using counter-current chromatography. |
| PubMed: | Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. |
| PubMed: | Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS. |
| PubMed: | [UPLC-MS analysis of constituents of dachuanxiong fang active parts absorbed into blood]. |
| PubMed: | [Studies on the chemical constituents of Ligusticum sinense]. |
| PubMed: | Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. |
| PubMed: | A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. |
| PubMed: | Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. |
| PubMed: | Roles of paeoniflorin and senkyunolide I in SiWu decoction on antiplatelet and anticoagulation activities. |
| PubMed: | [Analysis of volatile oils of Ligusticum chuanxiong Hort. from different geographical origins by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry]. |
| PubMed: | Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. |
| PubMed: | Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong. |
| PubMed: | Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. |
| PubMed: | [Pharmacological activities of Z-ligustilide and metabolites in rats]. |
| PubMed: | Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii. |
| PubMed: | Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. |
| PubMed: | Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS. |
| PubMed: | [Study on biligustilides from Angelica sinensis]. |
| PubMed: | GC-MS fingerprints for discrimination of Ligusticum chuanxiong from Angelica. |
| PubMed: | Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. |
| PubMed: | Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. |
| PubMed: | [Studies on chemical constituents of rhizomes of Ligusticum chuanxiong]. |
| PubMed: | Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC. |
| PubMed: | Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS. |
| PubMed: | Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed: | Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat. |
| PubMed: | Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. |
| PubMed: | Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong). |
| PubMed: | Screening and identification of permeable components in a combined prescription of Danggui Buxue decoction using a liposome equilibrium dialysis system followed by HPLC and LC-MS. |
| PubMed: | Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. |
| PubMed: | Time-course accumulation of main bioactive components in the rhizome of Ligusticum chuanxiong. |
| PubMed: | Antibacterial activity of components from Lomatium californicum. |
| PubMed: | [Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography]. |
| PubMed: | An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'. |
| PubMed: | Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS. |
| PubMed: | Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. |
| PubMed: | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. |
| PubMed: | Hypothesis of potential active components in Angelica sinensis by using biomembrane extraction and high performance liquid chromatography. |
| PubMed: | Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs. |
| PubMed: | HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong. |
| PubMed: | [Preparation of senkyunolide I by reversed-phase high performance liquid chromatography]. |
| PubMed: | [Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS]. |
| PubMed: | Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS. |
| PubMed: | Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry. |
| PubMed: | Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. |
| PubMed: | Separation and identification of the phthalic anhydride derivatives of Liqusticum Chuanxiong Hort by GC-MS, TLC, HPLC-DAD, and HPLC-MS. |
| PubMed: | Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds. |
| PubMed: | Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells. |
| PubMed: | Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells. |
| PubMed: | [Effects of extract from a herbal drug, cnidium rhizome (senkyu), on contraction, heart rates and membrane potentials of isolated guinea pig atria]. |
| PubMed: | [Centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino]. |
| PubMed: | The essential oil of Apium graveolens var. secalinum and its cercaricidal activity. |
| PubMed: | Phthalides in Roots of Capnophyllum peregrinum and Peucedanum ostruthium. |
| PubMed: | Phthalides in Roots of Opopanax chironium. |
| PubMed: | Phthalides in the essential oil from roots of Levisticum officinale. |
| PubMed: | [Constituents of Cnidium officinale Makino. Structure of senkyunolide and gas chromatography-mass spectrometory of the related phthalides (author's transl)]. |
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