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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 495.90 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 489.00 °F. TCC ( 253.70 °C. ) (est)
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| logP (o/w): | 3.440 (est) |
| Soluble in: |
| | water, 1.594e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-child TDLo 630 mg/kg/1W-I SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE"
GASTROINTESTINAL: NAUSEA OR VOMITING Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984.
intravenous-guinea pig LD50 57 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
intravenous-mouse LD50 86 mg/kg Biochemical Journal. Vol. 28, Pg. 426, 1934.
oral-mouse LD50 660 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
intravenous-rabbit LD50 35 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
oral-rabbit LD50 641 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
intravenous-rat LD50 78 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
oral-rat LD50 1392 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
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| Dermal Toxicity: |
subcutaneous-guinea pig LDLo 199 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for quinacrine dihydrochloride usage levels up to: | | | not for fragrance use.
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| Recommendation for quinacrine dihydrochloride flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 60-93-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 91429 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrochloride |
| Chemidplus: | 0000060935 |
| RTECS: | AR7875000 for cas# 60-93-5 |
References:
| | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrochloride |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 60-93-5 |
| Pubchem (cid): | 91429 |
| Pubchem (sid): | 135048003 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cinchonan-9-ol, 6'-methoxy-, (8a,9R)-, hydrochloride (1:2) | | | cinchonan-9-ol, 6'-methoxy-, dihydrochloride, (8a,9R)- | | (R)-[(2S,4S,5R)-5- | ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrochloride | | (8a,9R)-6'- | methoxycinchonan-9-ol dihydrochloride | | | quinine bihydrochloride | | | quinine bimuriate | | | quinine dihydrochloride | | (-)- | quinine dihydrochloride |
Articles:
| PubMed: | Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection. |
| PubMed: | Dexmedetomidine-induced contraction involves c-Jun NH2 -terminal kinase phosphorylation through activation of the 5-lipoxygenase pathway in the isolated endothelium-denuded rat aorta. |
| PubMed: | Gender determination from pulpal tissue. |
| PubMed: | Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle. |
| PubMed: | A novel method using an acedan-based Zn(DPA) probe to monitor ATP localization in an in vivo system. |
| PubMed: | Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants. |
| PubMed: | Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells. |
| PubMed: | Determination of sex from tooth pulp tissue. |
| PubMed: | The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release. |
| PubMed: | Direct effect of ropivacaine involves lipoxygenase pathway activation in rat aortic smooth muscle. |
| PubMed: | Direct effect of dexmedetomidine on rat isolated aorta involves endothelial nitric oxide synthesis and activation of the lipoxygenase pathway. |
| PubMed: | Variability in cytogenetic adaptive response of cultured human lymphocytes to mitomycin C, bleomycin, quinacrine dihydrochloride, Co60 gamma-rays and hyperthermia. |
| PubMed: | A one-year neonatal mouse carcinogenesis study of quinacrine dihydrochloride. |
| PubMed: | 2n-fatty acids from phosphatidylcholine label sphingolipids--a novel role of phospholipase A2? |
| PubMed: | The effect of chloroquine, quinacrine, and metronidazole on both soybean plants and soil microbiota. |
| PubMed: | 4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts. |
| PubMed: | Re-evaluation of the mutagenic potential of quinacrine dihydrochloride dihydrate. |
| PubMed: | Quinacrine dihydrochloride, the non-surgical female sterilant induces dicentrics, rings, and marker chromosomes in human peripheral blood lymphocytes treated in vitro: a preliminary report. |
| PubMed: | The pathway of cell senescence: WI-38 cells arrest in late G1 and are unable to traverse the cell cycle from a true G0 state. |
| PubMed: | Scaling lichenoid eruptions and Sjögren-like syndrome: manifestations of nonfatal postoperative transfusion-associated graft-versus-host disease? |
| PubMed: | Nuclear matrix condensation and c-myc and c-fos expression are specifically altered in culture rat hepatocytes after exposure to cyproterone acetate and phenobarbital. |
| PubMed: | Quinacrine staining of marginal cells in the stria vascularis of the guinea-pig cochlea: a possible source of extracellular ATP? |
| PubMed: | Coronary vasoconstriction is the most probable cause of death of rats intoxicated with botulinolysin, a hemolysin produced by Clostridium botulinum. |
| PubMed: | Conductometric study of interaction between dyes and surface active agents. |
| PubMed: | Nongenotoxic carcinogens shift cultured rat hepatocytes into G1 cell cycle phase: influence of tissue oxygen tension on cells with different ploidy. |
| PubMed: | Studies of lysophospholipids related to the hamster sperm acrosome reaction in vitro. |
| PubMed: | Application of image analysis on monolayer cultures of rat hepatocytes: assessment of a chemically inducible G0-G1 cell cycle phase shift. |
| PubMed: | Cytogenetics of bisexual/unisexual species of Poecilia. III. The karyotype of Poecilia formosa, a gynogenetic species of hybrid origin. |
| PubMed: | Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and -resistant Plasmodium falciparum in vitro. |
| PubMed: | [Acquired hydrocele in the adult: sclerotherapy]. |
| PubMed: | Micronucleus test on quinacrine dihydrochloride in mice: a comparison of dosage regimens. |
| PubMed: | Sex chromatin analysis of lymphocytes invading host organs in transfusion-associated graft-versus-host disease. |
| PubMed: | Distinction between the G0 and the late G1 phase of rat cells in vivo and in vitro with the nuclear QDH-fluorescence pattern. |
| PubMed: | Analysis of the G1 arrest position of senescent WI38 cells by quinacrine dihydrochloride nuclear fluorescence. Evidence for a late G1 arrest. |
| PubMed: | Proton translocation coupled to dimethyl sulfoxide reduction in anaerobically grown Escherichia coli HB101. |
| PubMed: | Drug-induced immunogenic changes of murine leukemia cells: dissociation of onset of resistance and emergence of novel immunogenicity. |
| PubMed: | Double Y as an indicator in a test of mitotic nondisjunction in cultured human lymphocytes. |
| PubMed: | G0-G1 transition of rat hepatocytes detected by changes in nuclear chromatin condensation after in vivo treatment with phenobarbital. |
| PubMed: | Induction of micronuclei in the mouse. Revised timing of the final stage of erythropoiesis. |
| PubMed: | Mechanisms involved in the synthesis of disaturated phosphatidylcholine by alveolar type II cells isolated from adult rat lung. |
| PubMed: | Improved fluorescence method for identifying sex chromatin in formalin-fixed tissue. |
| PubMed: | Fluorimetric measurements and chromatin condensation patterns of nuclei from 3T3 cells throughout G1. |
| PubMed: | Feasibility of testing DNA repair inhibitors for mutagenicity by a simple method. |
| PubMed: | Drug-mediated antigenic changes in murine leukemia cells: antagonistic effects of quinacrine, an antimutagenic compound. |
| PubMed: | Frequency of evident Barr and "F" corpuscles in tetraploid Purkinje neurons. |
| PubMed: | The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays. |
| PubMed: | Detection of aneuploidy in human sperm. |
| PubMed: | Metmyoglobin reductase. Identification and purification of a reduced nicotinamide adenine dinucleotide-dependent enzyme from bovine heart which reduces metmyoglobin. |
| PubMed: | Cell cycle dependent changes of chromosomes in mouse fibroblasts. |
| PubMed: | [Transvaginal sterilization of women--a review]. |
| PubMed: | Cytogenetic assays of chemical clastogens using mammalian cells in culture. |
| PubMed: | A cytological procedure to screen mammalian temperature-sensitive mutants for cell-cycle-related defects. |
| PubMed: | A simple fluorescence staining technique for the differentiation of human tissue transplanted into nude mice. |
| PubMed: | Effect of Hoechst 33258 on Chinese hamster chromosomes. |
| PubMed: | Prenatal sex determination by demonstration of Y body using fluorescent stain. |
| PubMed: | Fluorescent (F) bodies in the spermatozoa of man and the great apes. |
| PubMed: | [Identification of the XYY syndrome by quinacrine dihydrochloride fluorescence staining]. |
| PubMed: | Y bodies and similar fluorescent chromocentres in human tumours including teratomata. |
| PubMed: | Effects of pH on the migration of X and Y sperm. |
| PubMed: | Testing the hypothesis of Y translocation in XX males by fluorescence microscopy after quinacrine-dihydrochloride staining. |
| PubMed: | Identification of G group anomalies in Down's syndrome by quinacrine dihydrochloride fluorescence staining. |
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