Articles:
aerosporin
Notes:
a mixture of polymyxins b1 and b2, obtained from bacillus polymyxa strains. they are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. polymyxin b is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
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| CAS Number: | 1405-20-5 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 215-774-7 | |
| FDA UNII: | 19371312D4 | |
| MDL: | MFCD00131991 | |
| Molecular Weight: | 1189.36088000 | |
| Formula: | C48 H84 N16 O17 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1611.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 1703.00 °F. TCC ( 928.10 °C. ) (est) |
| logP (o/w): | -6.361 (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Polymyxin B sulfate >98%
Odor: characteristic Use: Polymyxin B sulfate is obtained from Bacillus polymyxa and related species as a mixture of polymyxins B1 and B2. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B (sulfate) is a mixtu
Gram-negative bacterial infections. |
| Glentham Life Sciences |
| Polymixin B sulfate salt |
| Penta International |
| POLYMYXIN-B-SULFATE USP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Polymyxin B Sulfate |
| Sigma-Aldrich |
| For experimental / research use only. |
| Polymyxin B Sulfate
pharmaceutical secondary standard; traceable to USP, PhEur, BP |
| Sinoway Industrial |
| For experimental / research use only. |
| polymyxin B sulphate |
| TCI AMERICA |
| For experimental / research use only. |
| Polymyxin B Sulfate |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-dog LDLo 8 mg/kg Investigative Urology. Vol. 6, Pg. 505, 1969. intraperitoneal-mouse LD50 20500 ug(base) Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960. intravenous-mouse LD50 5400 ug(base)/ Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960. oral-mouse LD50 790 mg(base)/k Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960. | |
| Dermal Toxicity: | |
|
subcutaneous-guinea pig LD50 58 mg/kg Chemotherapy Vol. 16, Pg. 105, 1968. subcutaneous-mouse LD50 59500 ug(base) Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for polymixin B sulfate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for polymixin B sulfate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3083708 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0001405205 |
| RTECS: | TR1150000 for cas# 1405-20-5 |
References:
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 3083708 |
| Pubchem (sid): | 135231011 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2941.90.5000 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Wikipedia2: | View2 |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| aerosporin | |
| chloromyxin | |
| neobacimyx | |
| neosporin plus | |
| pediotic suspension | |
| neo- | polycin |
| polymixin-b-sulfate | |
| polymyxin B sulfate | |
| polymyxin B sulphate | |
| polymyxin B, sulfate | |
| polymyxin B, sulfate (salt) | |
| polytrim |