Articles:
acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
Notes:
a local anesthetic and cardiac depressant used as an antiarrhythmia agent. its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
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American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): 154673 Lidocaine Hydrochloride USP
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 73-78-9 Lidocaine hydrochloride 98% Lidocaine hydrochloride is the first amino amide type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations,
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 12-38500 LIDOCAINE HYDROCHLORIDE ANHYDROUS USP
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| CAS Number: | 73-78-9 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-803-8 | |
| FDA UNII: | EC2CNF7XFP | |
| Beilstein Number: | 3917968 | |
| MDL: | MFCD00150329 | |
| Molecular Weight: | 270.80251000 | |
| Formula: | C14 H23 Cl N2 O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 350.80 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000043 mmHg @ 25.00 °C. (est) |
| Flash Point: | 331.00 °F. TCC ( 166.00 °C. ) (est) |
| logP (o/w): | 2.359 (est) |
| Soluble in: | |
| water, 1473 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| American International Chemical, LLC. |
| Lidocaine Hydrochloride USP |
| BOC Sciences |
| For experimental / research use only. |
| Lidocaine hydrochloride 98%
Odor: characteristic Use: Lidocaine hydrochloride is the first amino amide type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943.
Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations, |
| Maypro Industries |
| Lidocaine HCl |
| Penta International |
| LIDOCAINE HYDROCHLORIDE ANHYDROUS USP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Lidocaine Hydrochloride ≥99% |
| Sigma-Aldrich |
| For experimental / research use only. |
| Lidocaine Hydrochloride
European Pharmacopoeia (EP) Reference Standard |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-child TDLo 60 mg/kg/1H BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 51, 1986. intravenous-dog LDLo 65700 ug/kg Journal de Pharmacologie. Vol. 2, Pg. 240, 1971. parenteral-frog LD50 159 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987. intravenous-guinea pig LD50 24500 ug/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. intravenous-man TDLo 7143 ug/kg CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP Chest. Vol. 61, Pg. 682, 1972. intravenous-man TDLo 9 mg/kg/4H-C CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 669, 1985. intramuscular-mouse LD50 177 mg/kg Drug Development Research. Vol. 21, Pg. 277, 1990. intraperitoneal-mouse LD50 63 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985. intravenous-mouse LD50 15 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 48T, 1962. oral-mouse LD50 220 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. intratracheal-rabbit LD50 28 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. intravenous-rabbit LD50 25600 ug/kg Drugs in Japan Vol. 6, Pg. 879, 1982. intraperitoneal-rat LD50 122 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 224, 1954. intravenous-rat LD50 21 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 163 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 103, Pg. 353, 1960. subcutaneous-rat LD50 570 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for lidocaine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for lidocaine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 73-78-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6314 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride | |
| Chemidplus: | 0000073789 |
| RTECS: | AN7700000 for cas# 73-78-9 |
References:
| 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6314 |
| Pubchem (sid): | 134972951 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| KEGG (GenomeNet): | D02086 |
| HMDB (The Human Metabolome Database): | Search |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, chloride, hydrogen salt (1:1) | |
| acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1) | |
| acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride | |
| 2',6'- | acetoxylidide, 2-(diethylamino)-, hydrochloride |
| 2',6'- | acetoxylidide, 2-(diethylamino)-, monohydrochloride |
| anestacon hydrochloride | |
| a- | diethylamino-2,6-acetoxylidine hydrochloride |
| 2- | diethylamino-2',6'-acetoxylidide hydrochloride |
| ( | diethylamino)-2',6'-acetoxylidide monohydrochloride |
| 2-( | diethylamino)-n-(2,6-dimethylphenyl)-acetamide hydrochloride |
| 2-( | diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride |
| 2-( | diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride |
| 2-( | diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1) |
| 2-( | diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride |
| 2-( | diethylamino)-N-(2,6-dimethylphenyl)acetamidhydrochlorid |
| N-( | diethylaminoacetyl)-2,6-dimethylaniline hydrochloride |
| N-(2,6- | dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride |
| N-(2,6- | dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride |
| duncaine hydrochloride | |
| gravocain hydrochloride | |
| isicaine hydrochloride | |
| leostesin hydrochloride | |
| lidocain hydrochloride | |
| lidocaine HCl | |
| lidothesin hydrochloride | |
| lignocaine hydrochloride | |
| linocaine hydrochloride | |
| metaclopramide hydrochloride | |
| rucaina hydrochloride | |
| xilina hydrochloride | |
| xycaine hydrochloride | |
| xylestesin hydrochloride | |
| xylocaine hydrochloride | |
| xylocaine MPF | |
| xylocitin hydrochloride | |
| xylotox hydrochloride |