Articles:
| None found yet. Try the PubMed Search. |
ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-, butanedioate (1:1)
Notes:
histamine h1 antagonist with pronounced sedative properties. it is used in allergies and as an antitussive, antiemetic, and hypnotic. doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 562-10-7 Doxylamine Succinate >98% Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.
-
-
Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-91800 DOXLAMINE SUCCINATE USP
-
| CAS Number: | 562-10-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 209-228-7 | |
| FDA UNII: | V9BI9B5YI2 | |
| MDL: | MFCD00056168 | |
| Molecular Weight: | 388.46416000 | |
| Formula: | C21 H28 N2 O5 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 364.90 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000016 mmHg @ 25.00 °C. (est) |
| Flash Point: | 346.00 °F. TCC ( 174.50 °C. ) (est) |
| logP (o/w): | 2.519 (est) |
| Soluble in: | |
| water, 7.438e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Doxylamine Succinate >98%
Odor: characteristic Use: Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. |
| Penta International |
| DOXLAMINE SUCCINATE USP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Doxlamine Succinate |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Doxl Amine Succinate |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 62 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. oral-mouse LD50 470 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. intravenous-rabbit LD50 49 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. oral-rabbit LD50 250 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. oral-rat LDLo 600 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 311, 1948. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 460 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. subcutaneous-rat LD50 440 mg/kg Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for doxl amine succinate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for doxl amine succinate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 11224 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| butanedioicacid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine | |
| Chemidplus: | 0000562107 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | US9275000 for cas# 562-10-7 |
References:
| butanedioicacid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 11224 |
| Pubchem (sid): | 134977827 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C19414 |
| HMDB (The Human Metabolome Database): | HMDB01936 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| alsadorm | |
| bendectin | |
| butanedioic acid compd. with N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1) | |
| butanedioic acid, compd. with N, N-dimethyl-2-[1-phenyl-1- (2-pyridinyl)ethoxy]ethanamine (1:1) | |
| butanedioic acid, compd. with N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine (1:1) | |
| butanedioicacid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine | |
| contac nighttime cold medicine | |
| decapryn | |
| decarpyn succinate (1:1) | |
| N,N- | dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine butanedioate |
| N,N- | dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate (1:1) |
| N,N- | dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine butanedioate (1:1) |
| N,N- | dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine succinate (1:1) |
| 2-(a-(2- | dimethylaminoethoxy)-a-methylbenzyl)pyridine succinate |
| dimethylaminoethoxymethylbenzylpyridine succinate | |
| 2- | dimethylaminoethoxyphenylmethyl-2-picoline succinate |
| doxlamine succinate | |
| doxyl amine hydrogen succinate | |
| ethanamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]-, butanedioate (1:1) | |
| evigoa D | |
| gittalun | |
| hoggar N | |
| mereprine | |
| pyridine, 2-(a-(2-(dimethylamino)ethoxy)-a-methylbenzyl)-, succinate (1:1) | |
| pyridine, 2-[a-[2- (dimethylamino)ethoxy]-a-methylbenzyl]-, succinate (1:1) | |
| sedaplus | |
| unisom |