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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 543.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 541.00 °F. TCC ( 282.70 °C. ) (est)
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| logP (o/w): | 1.351 (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for dextromethorphan hydrobromide monohydrate usage levels up to: | | | not for fragrance use.
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| Recommendation for dextromethorphan hydrobromide monohydrate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dextromethorphan hydrobromide | | | drixoral cough | | | endotussin-NN pediatric | | (9a,13a,14a)-3- | methoxy-17-methylmorphinan hydrobromide dihydrate | | | morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide, hydrate (1:1:2) | | | pediacare 1 | | | robitussin cough calmers | | | robitussin maximum strength cough | | | robitussin pediatric cough | | | SAM001247062 | | | st. joseph cough syrup | | | tylenol cough liquid |
Articles:
| PubMed: | Dextromethorphan/quinidine for the treatment of pseudobulbar affect. |
| PubMed: | Pseudobulbar affect: prevalence and management. |
| PubMed: | Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6. |
| PubMed: | Effects of Ougan juice on P450 activities using a cocktail method. |
| PubMed: | Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. |
| PubMed: | Therapeutic options for acute cough due to upper respiratory infections in children. |
| PubMed: | Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs. |
| PubMed: | Advisers vote against declaring dextromethorphan a controlled substance. |
| PubMed: | Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages. |
| PubMed: | Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. |
| PubMed: | Postherpetic neuralgia. |
| PubMed: | (13)C breath tests in personalized medicine: fiction or reality? |
| PubMed: | Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. |
| PubMed: | Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects. |
| PubMed: | Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. |
| PubMed: | Overdose in infant caused by over-the-counter cough medicine. |
| PubMed: | Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design. |
| PubMed: | Dextromethorphan/quinidine sulfate for pseudobulbar affect. |
| PubMed: | Central mechanisms IV: conscious control of cough and the placebo effect. |
| PubMed: | Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. |
| PubMed: | Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. |
| PubMed: | Cough and cold medication use by US children, 1999-2006: results from the slone survey. |
| PubMed: | Unexpected infant deaths associated with use of cough and cold medications. |
| PubMed: | The causes and treatment of pseudobulbar affect in ischemic stroke. |
| PubMed: | The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. |
| PubMed: | The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat. |
| PubMed: | FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children? |
| PubMed: | Involuntary emotional expression disorder: treating the untreated. |
| PubMed: | Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. |
| PubMed: | A real reason for patients with pseudobulbar affect to smile. |
| PubMed: | Postherpetic neuralgia. |
| PubMed: | Effects of dextromethorphan on rats' acquisition of responding with delayed reinforcement. |
| PubMed: | Review of pseudobulbar affect including a novel and potential therapy. |
| PubMed: | Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. |
| PubMed: | Dextromethorphan-induced delirium and possible methadone interaction. |
| PubMed: | Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats. |
| PubMed: | Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching. |
| PubMed: | Down-regulation of hepatic CYP3A in chronic renal insufficiency. |
| PubMed: | Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial. |
| PubMed: | Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. |
| PubMed: | Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo. |
| PubMed: | Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. |
| PubMed: | Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity. |
| PubMed: | The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. |
| PubMed: | Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. |
| PubMed: | Cardiovascular sympathomimetic amine interactions in rats treated with monoamine oxidase inhibitors and the novel oxazolidinone antibiotic linezolid. |
| PubMed: | Cytochrome P450 expression and related metabolism in human buccal mucosa. |
| PubMed: | Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. |
| PubMed: | Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma(1) receptors. |
| PubMed: | Dextromethorphan alters methamphetamine self-administration in the rat. |
| PubMed: | Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail". |
| PubMed: | MorphiDex pharmacokinetic studies and single-dose analgesic efficacy studies in patients with postoperative pain. |
| PubMed: | Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. |
| PubMed: | Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys. |
| PubMed: | [Non-ketotic hyperglycinemia: clinical and therapeutic course in three patients]. |
| PubMed: | The stimulus properties of two common over-the-counter drug mixtures: dextromethorphan + ephedrine and dextromethorphan + diphenhydramine. |
| PubMed: | A massive outbreak of food poisoning--a reminder of the importance of proper toxic waste control. |
| PubMed: | Discriminative stimulus properties of dextromethorphan in rats. |
| PubMed: | Hazards of nonprescription medications. |
| PubMed: | Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist. |
| PubMed: | Polymorphisms in oxidative drug metabolism: relationship to food preference. |
| PubMed: | Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function. |
| PubMed: | Discriminative stimulus effects of dextrorphan in pigeons. |
| PubMed: | Discriminative stimulus effects of pentobarbital in rhesus monkeys: tests of stimulus generalization and duration of action. |
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