2,3,6-trimethyl pyridine
2,3,6-collidine
 
Notes:
None found
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CAS Number: 1462-84-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 215-970-2
FDA UNII: 0G31C4W0MI
Nikkaji Web: J40.072F
XlogP3-AA: 2.00 (est)
Molecular Weight: 121.18267000
Formula: C8 H11 N
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
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FDA Mainterm (IAUFC):1462-84-6 ; 2,3,6-TRIMETHYLPYRIDINE
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 171.60 °C. @ 760.00 mm Hg
Soluble in:
 water, 3.12E+04 mg/L @ 26C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for 2,3,6-trimethyl pyridine usage levels up to:
 not for fragrance use.
 
Recommendation for 2,3,6-trimethyl pyridine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 1462-84-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 15100
National Institute of Allergy and Infectious Diseases: Data
 2,3,6-trimethylpyridine
Chemidplus: 0001462846
EPA/NOAA CAMEO: hazardous materials
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References:
 2,3,6-trimethylpyridine
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 15100
Pubchem (sid): 134980508
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
2,3,6-collidine
 pyridine, 2,3,6-trimethyl-
2,3,6-trimethylpyridine
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Articles:
PubMed: NMR study of CHN hydrogen bond and proton transfer in 1,1-dinitroethane complex with 2,4,6-trimethylpyridine.
PubMed: Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives.
PubMed: Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae.
PubMed: Intrinsic proton-donating power of zinc-bound water in a carbonic anhydrase active site model estimated by NMR.
PubMed: [Determination of 2-acetyl-1-pyrroline in aroma rice using gas chromatography-mass spectrometry].
PubMed: Structural correlations for (1)H, (13)C and (15)N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with lutidines and collidine.
PubMed: Syntheses, structures and spectroscopy of uni- and bi-dentate nitrogen base complexes of silver(I) trifluoromethanesulfonate.
PubMed: Noncovalent synthesis of hierarchical zinc phosphates from a single Zn(4)O(12)P(4) double-four-ring building block: dimensionality control through the choice of auxiliary ligands.
PubMed: Synthesis and characterization of new Pd(II) complexes of L-ethylphenylalanate.
PubMed: Shape and electrostatic effects in optical Kerr effect spectroscopy of aromatic liquids.
PubMed: Heterocyclic compounds: toxic effects using algae, daphnids, and the Salmonella/microsome test taking methodical quantitative aspects into account.
PubMed: Nuclear magnetic resonance and ab initio studies of small complexes formed between water and pyridine derivatives in solid and liquid phases.
PubMed: Characterizing hydrogen bonding and proton transfer in 2:1 FH:NH3 and FH:collidine complexes through one- and two-bond spin-spin coupling constants across hydrogen bonds.
PubMed: pH of solution greatly affects sorption of ionizable compounds into low-density polyethylene film.
PubMed: Synthesis of 1,3,5-trisubstituted hydantoins by regiospecific domino condensation/aza-Michael/O-->N acyl migration of carbodiimides with activated alpha,beta-unsaturated carboxylic acids.
PubMed: Adsorption mechanism of substituted pyridines on silica suspensions: an NMR study.
PubMed: Monomeric, tetrameric, and polymeric copper di-tert-butyl phosphate complexes containing pyridine ancillary ligands.
PubMed: Low-temperature NMR studies of the structure and dynamics of a novel series of acid-base complexes of HF with collidine exhibiting scalar couplings across hydrogen bonds.
PubMed: Practical protocols for stepwise solid-phase synthesis of cysteine-containing peptides.
PubMed: Isolation of regioisomers of N-alkylprotoporphyrin IX from chick embryo liver after treatment with porphyrinogenic xenobiotics.
PubMed: The 1,2,4-triazolyl cation: thermolytic and photolytic studies.
PubMed: An improved procedure for N- to C-directed (Inverse) solid-phase peptide synthesis.
PubMed: The ether lipid ET-18-OCH3 increases cytosolic Ca2+ concentrations in Madin Darby canine kidney cells.
PubMed: Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal.
PubMed: Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis(1)(,)(2).
PubMed: Synthesis of the methyl alpha-glycosides of a di-, tri-, and a tetra-saccharide fragment mimicking the terminus of the O-polysaccharide of Vibrio cholerae O:1, serotype Ogawa.
PubMed: Evidence for mechanism-based inactivation of rat and chick embryo hepatic cytochrome P4501A and P4503A by dihydropyridines, sydnones, and dihydroquinolines.
PubMed: Mechanism-based inactivation of hepatic cytochrome P450 2C6 and P450 3A1 following in vivo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine to rats: differences from previously observed in vitro results.
PubMed: Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures.
PubMed: Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents.
PubMed: Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture. II.
PubMed: Synthesis and characterization of 6-O-beta-lactosyl-alpha,beta-D-mannopyranoses and 2,6-di-O-beta-lactosyl-alpha,beta-D-mannopyranoses.
PubMed: Inactivation of rat liver microsomal steroid hydroxylations by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine: evidence for selectivity among steroid-inducible cytochrome P450IIIA forms.
PubMed: Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
PubMed: Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats.
PubMed: Synergistic induction of delta-aminolevulinic acid synthase activity by N-ethylprotoporphyrin IX and 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-isobutylpyridine .
PubMed: Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.
PubMed: Systematic chemical synthesis and n.m.r. spectra of methyl alpha-glycosides of isomalto-oligosaccharides and related compounds.
PubMed: Synthesis of 4-methoxy-2,3,5-trimethylpyridine: a specific building block for compounds with gastric-acid inhibiting activity.
PubMed: Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450.
PubMed: Differential inhibition of hepatic ferrochelatase by regioisomers of N-butyl-, N-pentyl-, N-hexyl-, and N-isobutylprotoporphyrin IX.
PubMed: Synthesis of methyl 6''-deoxy-6'-fluoro-alpha-isomaltoside and of the corresponding trisaccharide.
PubMed: Xenobiotic mediated inhibition of hepatic uroporphyrinogen decarboxylase activity in 17-day-old chick embryo liver cells in culture.
PubMed: Effect of collidine (2,4,6-trimethylpyridine) on rat pineal gland and vas deferens nerves. Further evidence for a monoamine-releasing effect.
PubMed: Isolation of an N-alkylprotoporphyrin IX from chick embryo livers following the administration of 3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine.
PubMed: The 1986 Upjohn award lecture. Interaction of chemicals with hemoproteins: implications for the mechanism of action of porphyrinogenic drugs and nitroglycerin.
PubMed: Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) containing extended 4-alkyl groups: implications for the active site of ferrochelatase.
PubMed: Comparison of the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity and heme biosynthesis in chick embryo liver cells in culture.
PubMed: Chemical synthesis of the human Pk-antigenic determinant.
PubMed: Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.
PubMed: Ferrochelatase and N-alkylated porphyrins.
PubMed: Synthesis of methyl 3-O- and 2-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-alpha D-galactopyranoside.
PubMed: Chemical synthesis of the human blood-group P1-antigenic determinant.
PubMed: Patterns of porphyrin accumulation in response to chemicals in chick embryo liver cells.
PubMed: Investigation of the membrane-fluidizing properties of porphyrin-inducing drugs.
PubMed: Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by delta-aminolevulinic acid synthetase induction in chick embryo liver cell culture.
PubMed: Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes.
PubMed: Ferrochelatase-inhibitory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1, 4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells.
PubMed: Comparison of the effects of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity in chick embryo liver.
PubMed: Drug-induced porphyrin biosynthesis--XIX. Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase.
PubMed: Ascorbic acid and cytochrome P-450.
PubMed: [Free protoporphyrin in murine and rat erythrocytes. Study of experimental porphyrias induced through the administration of griseofulvin to mice and 3,5 diethoxycarbonyl-1,4 dihydro-2,4,6 trimethylpyridine (DDC) to rats].
PubMed: Properties of 5-aminolaevulinate synthetase and its relationship to microsomal mixed-function oxidation in the southern armyworm (Spodoptera eridania).
PubMed: Porphyria-inducing activity of a series of pyridine and dihydropyridine compounds. Investigation in a cell culture system.
PubMed: [EXPERIMENTAL PROPHYRIA INDUCED IN THE WHITE RAT BY DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE. INHIBITORY ACTION OF INOSINE ON THE EXAGGERATED PORPHYRINOGENESIS].
PubMed: Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.
PubMed: Experimental hepatic porphyria caused by feeding 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Comparison with sedormid porphyria.
PubMed: Porphyria induced in the rabbit by diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate. I. Excretion of 5-aminolaevulic acid, porphobilinogen, coproporphyrin and protoporphyrin.
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