4-methoxychalcone
2-propen-1-one, 3-(4-methoxyphenyl)-1-phenyl- (9CI)
 
Notes:
None found
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      Product(s):
      M1409 4-Methoxychalcone >98.0%(GC)
       
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CAS Number: 959-33-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 213-499-7
FDA UNII: Search
MDL: MFCD00017179
XlogP3: 3.10 (est)
Molecular Weight: 238.28598000
Formula: C16 H14 O2
NMR Predictor: Predict (works with chrome, Edge or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 397.30 °C. @ 760.00 mm Hg (est)
Flash Point: 357.00 °F. TCC ( 180.40 °C. ) (est)
logP (o/w): 3.960 (est)
Soluble in:
 water, 17.61 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
ExtraSynthese
For experimental / research use only.
4-Methoxychalcone (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
4-Methoxychalcone
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Methoxychalcone
TCI AMERICA
For experimental / research use only.
4-Methoxychalcone >98.0%(GC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for 4-methoxychalcone usage levels up to:
 not for fragrance use.
 
Recommendation for 4-methoxychalcone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 94197
National Institute of Allergy and Infectious Diseases: Data
 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
Chemidplus: 0000959331
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References:
 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 94197
Pubchem (sid): 135051757
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2914.50.3000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 chalcone, 4-methoxy- (8CI)
4'-methoxybenzylidene acetophenone
para-methoxyphenyl styryl ketone
3-(4-methoxyphenyl)-1-phenyl-2-propen-1-one
3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
 phenyl p-methoxystyryl ketone
2-propen-1-one, 3-(4-methoxyphenyl)-1-phenyl- (9CI)
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Articles:
PubMed: Two new chalcones from Clerodendrum phlomidis.
PubMed: In vitro action of flavonoids in the canine malignant histiocytic cell line DH82.
PubMed: Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.
PubMed: 4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells.
PubMed: Novel acetylated chalcone and biflavonoid glycosides from Trigonosciadium brachytaenium (Boiss.) Alava.
PubMed: 4,2',5'-trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages.
PubMed: 2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
PubMed: 2-hydroxy-4'-methoxychalcone inhibits proliferation and inflammation of human aortic smooth muscle cells by increasing the expression of peroxisome proliferator-activated receptor gamma.
PubMed: Kinetic analysis of some chalcones and synthetic chalcone analogues on the fenton-reaction initiated deoxyribose degradation assay.
PubMed: Two new chalcone glycosides from the stems of Entada phaseoloides.
PubMed: PPARα activation by culinary herbs and spices.
PubMed: Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.
PubMed: Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.
PubMed: Methoxy- and fluoro-chalcone derivatives arrest cell cycle progression and induce apoptosis in human melanoma cell A375.
PubMed: Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
PubMed: Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells.
PubMed: Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.
PubMed: Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity.
PubMed: Phytochemical investigation of Anaphalis lactea.
PubMed: Allergy-preventive flavonoids from Xanthorrhoea hastilis.
PubMed: Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. Rhizome.
PubMed: Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone.
PubMed: A new chromone from Ficus lyrata.
PubMed: Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells.
PubMed: Inclusion compounds of 2,5-diphenylhydroquinone.
PubMed: Inhibition of prostalglandin E2 production by 2'-hydoxychalcone derivatives and the mechanism of action.
PubMed: Androechin, a new chalcone glucoside from Andrographis echioides.
PubMed: In vitro leishmanicidal activity of naturally occurring chalcones.
PubMed: Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.
PubMed: Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.
PubMed: Chalcones, myo-inositol and other novel inhibitors of pulmonary carcinogenesis.
PubMed: Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation.
PubMed: Introduction of unnatural amino acids into chalcone isomerase.
PubMed: [Kinetics of the bacteriostatic activity of natural and synthetic chalcones on a strain of Staphylococcus aureus].
PubMed: Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat.
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