4-hydroxychalcone
3.2-propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-
 
Notes:
Constit. of Glycyrrhiza glabra (licorice) roots
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
      US Email: Sales
      Email: Technical Support
      Voice: 1-800-423-8616
      Fax: 1- 888-520-1075
      Facebook
      Twitter
      Instagram
      Linkedin
      Product(s):
      H0955 4-Hydroxychalcone >97.0%(HPLC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 20426-12-4Picture of molecule3D/inchi
MDL: MFCD00016488
XlogP3: 2.70 (est)
Molecular Weight: 224.25904000
Formula: C15 H12 O2
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 394.00 to  395.00 °C. @ 760.00 mm Hg (est)
Flash Point: 336.00 °F. TCC ( 168.60 °C. ) (est)
logP (o/w): 2.911 (est)
Soluble in:
 water, 240.3 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
ExtraSynthese
For experimental / research use only.
4-Hydroxychalcone (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
4-Hydroxychalcone ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Hydroxychalcone
TCI AMERICA
For experimental / research use only.
4-Hydroxychalcone >97.0%(HPLC)(T)
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: natural substances and extractives
Recommendation for 4-hydroxychalcone usage levels up to:
 not for fragrance use.
 
Recommendation for 4-hydroxychalcone flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 89340
National Institute of Allergy and Infectious Diseases: Data
 hydroxyphenyl)-1-phenylprop-2-en-1-one
Chemidplus: 0020426124
Synonyms   Articles   Notes   Search   Top
References:
 hydroxyphenyl)-1-phenylprop-2-en-1-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 89340
Pubchem (sid): 135046271
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C14231
HMDB (The Human Metabolome Database): HMDB32584
FooDB: FDB010521
Export Tariff Code: 2914.50.3000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 hop spent hops
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
4-hydroxy chalcone
4-hydroxybenzylidene acetophenone
3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one
3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
3.2-propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
PubMed: Effect of TSHAC on human cytochrome P450 activity, and transport mediated by P-glycoprotein.
PubMed: Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.
PubMed: Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone.
PubMed: Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.
PubMed: The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition.
PubMed: Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).
PubMed: Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib.
PubMed: 4'-Acetoamido-4-hydroxychalcone, a chalcone derivative, inhibits glioma growth and invasion through regulation of the tropomyosin 1 gene.
PubMed: PPARα activation by culinary herbs and spices.
PubMed: Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone.
PubMed: Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative.
PubMed: Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I.
PubMed: New prenylchalcones from the hops of Humulus lupulus.
PubMed: Sulfonate chalcone as new class voltage-dependent K+ channel blocker.
PubMed: Comparison of the effects of selected chalcones, dihydrochalcones and some cyclic flavonoids on mitochondrial outer membrane determined by fluorescence spectroscopy.
PubMed: A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.
PubMed: Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
PubMed: The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase.
PubMed: Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety.
PubMed: Hydroxychalcones exhibit differential effects on XRE transactivation.
PubMed: Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.
PubMed: Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities.
PubMed: Electron ionization induced fragmentation of 4-hydroxychalcone derivatives.
PubMed: Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.
PubMed: Inhibition of glutathione reductase by plant polyphenols.
PubMed: The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2021 Perflavory ™ Disclaimer Privacy Policy