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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 588.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 408.00 °F. TCC ( 208.90 °C. ) (est)
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| logP (o/w): | 2.550 (est) |
| Soluble in: |
| | water, 54.85 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Artemitin 98%
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| BOC Sciences |
| For experimental / research use only. |
| Artemetin 99%
Odor: characteristic Use: Artemetin comes from the herbs of Achillea millefolium L. Acting as antioxidant and antiapoptotic agent and through the activation of ERK1/2 and Akt, Artemetin protects endothelial function.
antiproliferative; inhibits apoptosis; anti-inflammatory |
| Coompo |
| For experimental / research use only. |
| Artemetin from Plants ≥96%
Odor: characteristic Use: The artemetin showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.
This flavonoid was able to dose-dependently reduce the MAP, up to 11.47 ± 1.5 mm Hg (1.5 mg/kg, i.v.). To investigate if artemetin-induced hypotension was related to angiotensin-converting enzyme inhibition, we evaluated the influence of this flavonoid on the vascular effects of both angiotensin I and bradykinin. Intravenous injection of artemetin (0.75 mg/kg) significantly reduced the hypertensive response to angiotensin I while increased the average length of bradykinin-induced hypotension. Artemetin (1.5 mg/kg, p.o.) was also able to reduce plasma (about 37%) and vascular (up to 63%) ACE activity in vitro, compared to control group. On the other hand, artemetin did not change angiotensin II-induced hypertension. Our study disclosed that this effect may be, at least in part, associated with high levels of artemetin and its ability to decrease angiotensin II generation in vivo, by ACE inhibition. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for artemetin usage levels up to: | | | not for fragrance use.
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| Recommendation for artemetin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5320351 |
| Pubchem (sid): | 135026029 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | artemisetin | | 4H-1- | benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy- | | | combretol | | 2-(3,4- | dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one | | 2-(3,4- | dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one | | 2-(3,4- | dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one | | | erianthin | | | flavone, 5-hydroxy-3,3',4',6,7-pentamethoxy- | | 5- | hydroxy-3,3',4',6,7-pentamethoxyflavone | | 5- | hydroxy-3,6,7,3',4'-pentamethoxyflavone | | | penta-O-methylquercetagetin | | | quercetagetin-3,6,7,3',4'-pentamethylether |
Articles:
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