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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 413.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 425.00 °F. TCC ( 218.20 °C. ) (est)
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| logP (o/w): | 0.040 (est) |
| Soluble in: |
| | water, 5.842e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for glutaconic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for glutaconic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| trans- | glutaconate | | (E)- | glutaconic acid | | | pent-2-ene-1,5-dioic acid | | (2E)- | pent-2-enedioic acid | | (E)- | pent-2-enedioic acid | | 2- | pentene dioic acid | | (2E)-2- | pentenedioic acid | | 2- | pentenedioic acid, (2E)- |
Articles:
| PubMed: | One-pot formation of 2,4-di- or 2,4,6-tri-olefinic monocarboxylic acids by straight chain C4-extension. |
| PubMed: | Experimental Evidence of Long-Range Intramolecular Vibrational Energy Redistribution through Eight Covalent Bonds: NIR Irradiation Induced Conformational Transformation of E-Glutaconic Acid. |
| PubMed: | Favourable Outcome in Two Pregnancies in a Patient with 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency. |
| PubMed: | Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM. |
| PubMed: | Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. |
| PubMed: | An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. |
| PubMed: | Clinical and molecular investigation in Chinese patients with glutaric aciduria type I. |
| PubMed: | Base-catalyzed bicyclization of dialkyl glutaconates with cinnamoylacetamides: a synthetic strategy for isoquinolinedione derivatives. |
| PubMed: | Diagnosis by whole exome sequencing of atypical infantile onset Alexander disease masquerading as a mitochondrial disorder. |
| PubMed: | Catalytic asymmetric Tamura cycloadditions. |
| PubMed: | Brain MRI findings as an important diagnostic clue in glutaric aciduria type 1. |
| PubMed: | Neurotoxic effects of trans-glutaconic acid in rats. |
| PubMed: | Diagnosis and management of glutaric aciduria type I--revised recommendations. |
| PubMed: | Production of glutaconic acid in a recombinant Escherichia coli strain. |
| PubMed: | Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme. |
| PubMed: | Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones. |
| PubMed: | Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I). |
| PubMed: | Basidiochrome -- a novel siderophore of the Orchidaceous Mycorrhizal Fungi Ceratobasidium and Rhizoctonia spp. |
| PubMed: | Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency. |
| PubMed: | Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I. |
| PubMed: | 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin. |
| PubMed: | 3-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells. |
| PubMed: | [Glutaric aciduria type 1: an example of the importance of early detection of so-called cerebral organic aciduria]. |
| PubMed: | On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1. |
| PubMed: | Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction. |
| PubMed: | Hydrogen-bonded complexes of 2-pyridone with centrosymmetric and non-centrosymmetric dicarboxylic acids. |
| PubMed: | Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids. |
| PubMed: | Sensitivity and specificity of free and total glutaric acid and 3-hydroxyglutaric acid measurements by stable-isotope dilution assays for the diagnosis of glutaric aciduria type I. |
| PubMed: | 3-Methyl glutaconic aciduria in Iraqi Jewish children may be misdiagnosed as cerebral palsy. |
| PubMed: | Nerve cell lesions caused by 3-hydroxyglutaric acid: a possible mechanism for neurodegeneration in glutaric acidaemia I. |
| PubMed: | Subdural hemorrhage as an initial sign of glutaric aciduria type 1: a diagnostic pitfall. |
| PubMed: | Sodium ion-dependent hydrogen production in Acidaminococcus fermentans. |
| PubMed: | Chronic subdural hematoma, as an initial manifestation of glutaric aciduria type-1. |
| PubMed: | Organic acid and acylcarnitine profiles of glutaric aciduria type I. |
| PubMed: | A biotin-dependent sodium pump: glutaconyl-CoA decarboxylase from Acidaminococcus fermentans. |
| PubMed: | 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in an infant with macrocephaly and mild metabolic acidosis. |
| PubMed: | The identification of (E)-2-methylglutaconic acid, a new isoleucine metabolite, in the urine of patients with beta-ketothiolase deficiency, propionic acidaemia and methylmalonic acidaemia. |
| PubMed: | Glutaconate CoA-transferase from Acidaminococcus fermentans. |
| PubMed: | The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate. |
| PubMed: | Glutaric aciduria: clinical and laboratory findings in two brothers. |
| PubMed: | Glutaconic acid, a product of the fermentation of glutamic acid by Peptococcus aerogenes. |
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