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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 417.51 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 367.00 °F. TCC ( 185.90 °C. ) (est)
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| logP (o/w): | 0.733 (est) |
| Soluble in: |
| | water, 59.65 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for artemisitene usage levels up to: | | | not for fragrance use.
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| Recommendation for artemisitene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3R-(3alpha,5abeta,6beta,8abeta,12beta,12aR*))- | octahydro-3,6-dimethyl-9-methylene-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one |
Articles:
| PubMed: | Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms. |
| PubMed: | A rapid method for the determination of artemisinin and its biosynthetic precursors in Artemisia annua L. crude extracts. |
| PubMed: | Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin. |
| PubMed: | Production of Artemisinin and Related Sesquiterpenes in Japanese Artemisia annua During a Vegetation Period. |
| PubMed: | From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. |
| PubMed: | Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry. |
| PubMed: | Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines. |
| PubMed: | Recent advances in artemisinin and its derivatives as antimalarial and antitumor agents. |
| PubMed: | Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. |
| PubMed: | Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. |
| PubMed: | C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene. |
| PubMed: | Acid catalyzed Michael additions to artemisitene. |
| PubMed: | Microbial metabolism of artemisitene. |
| PubMed: | Stereochemistry-dependent cytotoxicity of some artemisinin derivatives. |
| PubMed: | Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. |
| PubMed: | Immunoquantitative analysis of artemisinin from Artemisia annua using polyclonal antibodies. |
| PubMed: | Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. |
| PubMed: | Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives. |
| PubMed: | Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells. |
| PubMed: | In vitro chloroquine resistant Plasmodium falciparum in Calcutta and its sensitivity to qinghaosu (artemisitene). |
| PubMed: | Conversion of artemisinin (qinghaosu) to iso-artemisitene and to 9-epi-artemisinin1. |
| PubMed: | Artemisitene, a New Sesquiterpene Lactone Endoperoxide from Artemisia annua. |
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