methysticin, 495-85-2

Articles:

PubMed:	Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
PubMed:	Quantitative Determination of Lactones in Piper methysticum (Kava-Kava) by Supercritical Fluid Chromatography.
PubMed:	Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents.
PubMed:	Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.
PubMed:	Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage.
PubMed:	Kavalactone metabolism in rat liver microsomes.
PubMed:	Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells.
PubMed:	Kavalactone metabolism in the isolated perfused rat liver.
PubMed:	Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice.
PubMed:	Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
PubMed:	Proposal for a kava quality standardization code.
PubMed:	Herbal bioactivation, molecular targets and the toxicity relevance.
PubMed:	Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
PubMed:	Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
PubMed:	Highly regio- and stereoselective Heck reaction of allylic esters with arenediazonium salts: application to the synthesis of kavalactones.
PubMed:	Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.
PubMed:	High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites.
PubMed:	Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots.
PubMed:	Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation.
PubMed:	Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
PubMed:	Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
PubMed:	Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation.
PubMed:	Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones.
PubMed:	Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).
PubMed:	Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
PubMed:	Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.
PubMed:	Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
PubMed:	Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.
PubMed:	Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
PubMed:	Determination of kava lactones in food supplements by liquid chromatography-atmospheric pressure chemical ionisation tandem mass spectrometry.
PubMed:	Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
PubMed:	LC-UV and LC-MS analysis of food and drink products containing kava.
PubMed:	Analysis of kavalactones from Piper methysticum (kava-kava).
PubMed:	Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.
PubMed:	Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
PubMed:	Kava does not display metabolic toxicity in a homogeneous cellular assay.
PubMed:	Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
PubMed:	Inhibition of human cytochrome P450 activities by kava extract and kavalactones.
PubMed:	Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.
PubMed:	Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots.
PubMed:	Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
PubMed:	Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.
PubMed:	Microbial transformation of kawain and methysticin.
PubMed:	Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava).
PubMed:	Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats.
PubMed:	Influence of genuine kavapyrone enantiomers on the GABA-A binding site.
PubMed:	Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.
PubMed:	Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons.
PubMed:	Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract.
PubMed:	Piper methysticum: enantiomeric separation of kavapyrones by high performance liquid chromatography.
PubMed:	Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices.
PubMed:	Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.
PubMed:	The antinociceptive actions of kava components in mice.
PubMed:	Metabolism of some kava pyrones in the rat.
PubMed:	[Quantitative determination of kawa lactones in Piper methysticum (Forster). 2. Determination of kawain, methysticin and yangonin].
PubMed:	[Quantitative determination of kawa-lactones in Piper methysticum (Forster). 1. Determination methods with pure substances kawain, methysticin and yangonin].