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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 646.26 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 456.00 °F. TCC ( 235.60 °C. ) (est)
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| logP (o/w): | -2.411 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for loganic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for loganic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 89640 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid |
| Chemidplus: | 0022255409 |
References:
| | (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 89640 |
| Pubchem (sid): | 135045957 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (1S,4aS,6S,7R,7aS)-6-hydroxy-7- | methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid |
Articles:
| PubMed: | [Content of gentiopicroside and loganic acid in Radix gentianae and their fingerprints]. |
| PubMed: | [Content determination of loganic acid and gentiopicroside in Tebitan herbal medicines Gentiana macrophylla and G. straminea by HPLC]. |
| PubMed: | Spatial variation profiling of four phytochemical constituents in Gentiana straminea (Gentianaceae). |
| PubMed: | Rapid preparative separation of six bioactive compounds from Gentiana crassicaulis Duthie ex Burk. using microwave-assisted extraction coupled with high-speed counter-current chromatography. |
| PubMed: | Effect of alkali metal cationization and multiple alkali metal exchange on the collision-induced dissociation of loganic acid studied by electrospray ionization tandem mass spectrometry |
| PubMed: | Anti-inflammatory effect of three iridoids in human neutrophils. |
| PubMed: | A novel lactone from Tripterospermum chinense. |
| PubMed: | S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea. |
| PubMed: | Carboxyl group methylation of loganic acid by a cell-free enzyme preparation from Vinca rosea. |
| PubMed: | Monoterpene biosynthesis. I. Occurrence and mevalonoid origin of gentiopicroside and loganic acid in Swertia caroliniensis. |
| PubMed: | Enzymic synthesis of loganin by carboxyl group methylation of loganic acid. |
| PubMed: | Two novel secoiridoid glucosides from Tripterospermum chinense. |
| PubMed: | Comparative study on "long-dan", "qin-jiao" and their adulterants by HPLC analysis. |
| PubMed: | Metabolic discrimination of Swertia mussotii and Swertia chirayita known as "Zangyinchen" in traditional Tibetan medicine by (1)H NMR-based metabolomics. |
| PubMed: | Simultaneous determination of six index constituents and comparative analysis of four ethnomedicines from genus Gentiana using a UPLC-UV-MS method. |
| PubMed: | Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy. |
| PubMed: | Unexpected secoiridoid glucosides from Manulea corymbosa. |
| PubMed: | [Simultaneous determination of five iridoids in gentianae macrophyllae radix and their local variety by HPLC]. |
| PubMed: | Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats. |
| PubMed: | [Efficient method for analyzing absorbed ingredients of traditional Chinese medicine genitana macrophyllae radix]. |
| PubMed: | Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC. |
| PubMed: | [Studies on the chemical constituents from stems and leaves of Lonicera macranthoides]. |
| PubMed: | Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. |
| PubMed: | A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products. |
| PubMed: | [Determination of five active constituents in aerial part of Tibetan medicine Gentiana straminea by HPLC]. |
| PubMed: | A new iridoid glycoside and potential MRB inhibitory activity of isolated compounds from the rhizomes of Cyperus rotundus L. |
| PubMed: | UPLC-TOF-MS Characterization and Identification of Bioactive Iridoids in Cornus mas Fruit. |
| PubMed: | Coumarin glycosides and iridoid glucosides with neuroprotective effects from Hydrangea paniculata. |
| PubMed: | Phytochemical analysis of Plantago sempervirens from Majella National Park. |
| PubMed: | [Chemical constituents of glucoside fraction from Liuwei Dihuang Gantang]. |
| PubMed: | The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites. |
| PubMed: | A new iridoid glycoside from the roots of Dipsacus asper. |
| PubMed: | Lamiridosins, hepatitis C virus entry inhibitors from Lamium album. |
| PubMed: | Concentrations of the active constituents of the Tibetan folk medicine Qinjiao (Gentiana sect. Cruciata) within and between taxonomic species across the Qinghai-Tibetan Plateau. |
| PubMed: | Iridoid and phenylethanoid glucosides from Veronica lavaudiana. |
| PubMed: | Simultaneous determination of four iridoid and secoiridoid glycosides and comparative analysis of Radix Gentianae Macrophyllae and their related substitutes by HPLC. |
| PubMed: | [Studies on glycosides from Gentiana veitchiorum]. |
| PubMed: | Iridoidal glucosides from Gentiana rhodantha. |
| PubMed: | Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique. |
| PubMed: | 2,4-D and alkaloid accumulation in periwinkle cell suspensions. |
| PubMed: | The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. |
| PubMed: | Iridoids from Spathodea campanulata P. Beauvais leaves. |
| PubMed: | Iridoids from Gentiana loureirii. |
| PubMed: | A comparative chemotaxonomic study on Vinca sardoa steam and Vinca difformis pourret. |
| PubMed: | Iridoid glucosides from Strychnos nux-vomica. |
| PubMed: | Iridoids and secoiridoids from Guettarda platypoda. |
| PubMed: | Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. |
| PubMed: | Iridoids from Lippia graveolens. |
| PubMed: | Iridoid glycosides of Leonurus persicus. |
| PubMed: | An iridoid glucoside from dipsacus asperoides. |
| PubMed: | 4'-P-Coumaroyl Iridoid Glucosides from Gentiana pedicellata. |
| PubMed: | Iridoidic pattern in endemic Sardinian plants: the case of Galium species. |
| PubMed: | [Studies on chemical constituents of Eriophyton wallichii]. |
| PubMed: | Phenylethanoid and iridoid glycosides from the Thai medicinal plant, Barleria strigosa. |
| PubMed: | Chemistry of plants from Crete: stachyspinoside, a new flavonoid glycoside and iridoids from Stachys spinosa. |
| PubMed: | Selective sequestration of iridoid glycosides from their host plants in Longitarsus flea beetles. |
| PubMed: | Iridoids from Loasa acerifolia. |
| PubMed: | Secoiridoid glycosides and an antifungal anthranilate derivative from Gentiana tibetica. |
| PubMed: | Structural considerations on the iridoids as anti-inflammatory agents. |
| PubMed: | Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus. |
| PubMed: | Studies on lens-aldose-reductase inhibitor in medicinal plants. II. Active constituents of Monochasma savatierii Franch. et Maxim. |
| PubMed: | Iridoids from Scaevola racemigera1. |
| PubMed: | Senburiside II, a New Iridoid Glucoside from Swertia japonica. |
| PubMed: | Iridoids from Scutellaria albida ssp. albida. |
| PubMed: | Isolation of iridoid and secoiridoid glycosides and comparative study on Radix gentianae and related adulterants by HPLC analysis. |
| PubMed: | Metabolic discrimination of Catharanthus roseus leaves infected by phytoplasma using 1H-NMR spectroscopy and multivariate data analysis. |
| PubMed: | Iridoids from seeds of Gentiana lutea. |
| PubMed: | Cantleyoside-dimethyl-acetal and other iridoid glucosides from Pterocephalus perennis--antimicrobial activities. |
| PubMed: | Iridoid glycosides from Gmelina philippensis. |
| PubMed: | Inerminosides A and B, two novel complex iridoid glycosides from Clerodendrum inerme. |
| PubMed: | A Secoiridoid Glucoside from Gentiana scabra var. buergeri. |
| PubMed: | Iridoid Glucoside of Swertia japonica. |
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