tremetone
ethanone, 1-(2,3-dihydro-2-(1-methylethenyl)-5-benzofuranyl)-, (R)- (9CI)
 
Notes:
None found
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CAS Number: 4976-25-4Picture of molecule3D/inchi
FDA UNII: 451MA27V7H
Nikkaji Web: J8.791B
XlogP3-AA: 2.90 (est)
Molecular Weight: 202.25298000
Formula: C13 H14 O2
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 42.93 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for tremetone usage levels up to:
 not for fragrance use.
 
Recommendation for tremetone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 78673
National Institute of Allergy and Infectious Diseases: Data
 1-[(2R)-2-prop-1-en-2-yl-2,3-dihydro-1-benzofuran-5-yl]ethanone
Chemidplus: 0004976254
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References:
 1-[(2R)-2-prop-1-en-2-yl-2,3-dihydro-1-benzofuran-5-yl]ethanone
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 78673
Pubchem (sid): 135036624
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C08992
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 artemesia monosperma
Search Trop  Picture
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Synonyms:
(R)-1-(2,3-dihydro-2-(1-methyl ethenyl)-5-benzofuranyl) ethanone
(R)-1-(2,3-dihydro-2-(1-methylethenyl)-5-benzofuranyl)ethanone
 ethanone, 1-(2,3-dihydro-2-(1-methylethenyl)-5-benzofuranyl)-, (R)- (9CI)
 ketone, 2,3-dihydro-2-isopropenyl-5-benzofuranyl methyl (8CI)
1-[(2R)-2-prop-1-en-2-yl-2,3-dihydro-1-benzofuran-5-yl]ethanone
 tremeton
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Articles:
PubMed: Toxicity of white snakeroot (Ageratina altissima) and chemical extracts of white snakeroot in goats.
PubMed: A survey of tremetone, dehydrotremetone, and structurally related compounds in Isocoma spp. (goldenbush) in the southwestern United States.
PubMed: Physiological and serum biochemical changes associated with rayless goldenrod (Isocoma pluriflora) poisoning in goats.
PubMed: Experimental rayless goldenrod (Isocoma pluriflora) toxicosis in horses.
PubMed: Chemical composition, antimicrobial and antioxidant properties of the volatile oil and methanol extract of Xenophyllum poposum.
PubMed: Evaluation of analgesic activities of tremetone derivatives isolated from the Chilean altiplano medicine Parastrephia lepidophylla.
PubMed: Evaluation of drying methods and toxicity of rayless goldenrod ( Isocoma pluriflora ) and white snakeroot ( Ageratina altissima ) in goats.
PubMed: Development of a gas chromatography-mass spectrometry technique to diagnose white snakeroot (Ageratina altissima) poisoning in a cow.
PubMed: Tremetone and structurally related compounds in white snakeroot ( Ageratina altissima ): a plant associated with trembles and milk sickness.
PubMed: Quantitative method for the measurement of three benzofuran ketones in rayless goldenrod (Isocoma pluriflora) and white snakeroot (Ageratina altissima) by high-performance liquid chromatography (HPLC).
PubMed: Stereoselective syntheses of the 2-Isopropenyl-2,3-dihydrobenzofuran nucleus: potential chiral building blocks for the syntheses of tremetone, hydroxytremetone, and rotenone.
PubMed: Seasonal pasture myopathy in horses in the midwestern United States: 14 cases (1998-2005).
PubMed: New dihydrobenzofurans and triterpenoids from roots of Microglossa pyrifolia.
PubMed: Anti-inflammatory activity of acetophenones from Ophryosporus axilliflorus.
PubMed: Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor.
PubMed: Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis.
PubMed: Isolation of the major component in white snakeroot that is toxic after microsomal activation: possible explanation of sporadic toxicity of white snakeroot plants and extracts.
PubMed: Natural plant toxicants in milk: a review.
PubMed: Eupatoriopicrin 19-O-Linolenoate and Other Constituents from Eupatorium cannabium.
PubMed: Weitere Phloroglucin- und alpha-Pyron-Derivate aus Helichrysum-Arten.
PubMed: THE SYNTHESIS AND PHARMACOLOGICAL ACTION OF TREMETONE.
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