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Category: sweeteners, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 662.00 to 663.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 670.00 °F. TCC ( 354.60 °C. ) (est)
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| logP (o/w): | -4.606 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | sweeteners, flavor enhancers |
| Recommendation for isomaltose usage levels up to: | | | not for fragrance use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 10357 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (2R,3R,4S,5S,6R)-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol |
| Chemidplus: | 0000499401 |
References:
| | (2R,3R,4S,5S,6R)-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10357 |
| Pubchem (sid): | 135269668 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6-O-alpha-D- | glucopyranosyl-D-glucose | | 6-O-alpha-dextro- | glucopyranosyl-dextro-glucose | | (2R,3R,4S,5S,6R)-6-[[(2S,3R,4S,5S,6R)-3,4,5- | trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol |
Articles:
| PubMed: | Construction of dextrin and isomaltose-assimilating brewer's yeasts for production of low-carbohydrate beer. |
| PubMed: | Metabolism of isomalto-oligosaccharides by Lactobacillus reuteri and bifidobacteria. |
| PubMed: | Simple, fast, and efficient process for producing and purifying trehalulose. |
| PubMed: | Evidence for cycloisomaltooligosaccharide production from starch by Bacillus circulans T-3040. |
| PubMed: | Different sucrose-isomaltase response of Caco-2 cells to glucose and maltose suggests dietary maltose sensing. |
| PubMed: | The effect of lactose-isomaltulose-containing growing-up milks on cognitive performance of Indonesian children: a cross-over study. |
| PubMed: | Simple, fast, and efficient process for producing and purifying trehalulose. |
| PubMed: | Enzymatic properties of a thermostable α-glucosidase from acidothermophilic crenarchaeon Sulfolobus tokodaii strain 7. |
| PubMed: | Enhancing isomaltulose production by recombinant Escherichia coli producing sucrose isomerase: culture medium optimization containing agricultural wastes and cell immobilization. |
| PubMed: | Mature-stem expression of a silencing-resistant sucrose isomerase gene drives isomaltulose accumulation to high levels in sugarcane. |
| PubMed: | Influence of processing on the volatile profile of strawberry spreads made with isomaltulose. |
| PubMed: | NMR characterization of saccharides in Italian honeys of different floral sources. |
| PubMed: | Immobilization of glucosyltransferase from Erwinia sp. using two different techniques. |
| PubMed: | A rapid analytical method for the detection of plasma volume expanders and mannitol based on the urinary saccharides and polyalcohols profile. |
| PubMed: | Isomaltulose is actively metabolized in plant cells. |
| PubMed: | Isomaltulose production via yeast surface display of sucrose isomerase from Enterobacter sp. FMB-1 on Saccharomyces cerevisiae. |
| PubMed: | A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice. |
| PubMed: | Expression, purification and characterization of recombinant α-glucosidase in Pichia pastoris. |
| PubMed: | The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides. |
| PubMed: | Studies on absorption and metabolism of palatinose (isomaltulose) in rats. |
| PubMed: | Microbial production of palatinose through extracellular expression of a sucrose isomerase from Enterobacter sp. FMB-1 in Lactococcus lactis MG1363. |
| PubMed: | Cloning and characterization of a sucrose isomerase from Erwinia rhapontici NX-5 for isomaltulose hyperproduction. |
| PubMed: | Palatinose-blended sugar compared with sucrose: different effects on insulin sensitivity after 12 weeks supplementation in sedentary adults. |
| PubMed: | Novel findings on the metabolic effects of the low glycaemic carbohydrate isomaltulose (Palatinose). |
| PubMed: | Manipulation of glycemic response with isomaltulose in a milk-based drink does not affect cognitive performance in healthy adults. |
| PubMed: | Effect of concentration and substrate flow rate on isomaltulose production from sucrose by Erwinia sp. cells immobilized in calcium-alginate using packed bed reactor. |
| PubMed: | Beneficial effects on glucose metabolism of chronic feeding of isomaltulose versus sucrose in rats. |
| PubMed: | [Analyse of sugars in beer and wort using high performance anion-exchange chromatography coupled with pulsed amperometric detection]. |
| PubMed: | Analysis of sugars in Chinese rice wine by Fourier transform near-infrared spectroscopy with partial least-squares regression. |
| PubMed: | Food labeling: health claims; dietary noncariogenic carbohydrate sweeteners and dental caries. Final rule. |
| PubMed: | Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of alpha-glucosylsaccharides in the small intestine. |
| PubMed: | Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis. |
| PubMed: | Starch with a slow digestion property produced by altering its chain length, branch density, and crystalline structure. |
| PubMed: | Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus. |
| PubMed: | Isomaltulose production using free cells: optimisation of a culture medium containing agricultural wastes and conversion in repeated-batch processes. |
| PubMed: | Conversion of sucrose into isomaltulose by Enterobacter sp. FMB1, an isomaltulose-producing microorganism isolated from traditional Korean food. |
| PubMed: | Application of response surface methodology to cell immobilization for the production of palatinose. |
| PubMed: | Crystal structure of pullulanase: evidence for parallel binding of oligosaccharides in the active site. |
| PubMed: | Molecular characterization of the alpha-glucosidase activity in Enterobacter sakazakii reveals the presence of a putative gene cluster for palatinose metabolism. |
| PubMed: | Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium. |
| PubMed: | Application of a fast high-performance liquid chromatography method for simultaneous determination of furanic compounds and glucosylisomaltol in breakfast cereals. |
| PubMed: | Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia. |
| PubMed: | Isomaltooligosaccharide increases cecal Bifidobacterium population in young broiler chickens. |
| PubMed: | Klebsiella singaporensis sp. nov., a novel isomaltulose-producing bacterium. |
| PubMed: | Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion. |
| PubMed: | Properties of a novel thermostable glucoamylase from the hyperthermophilic archaeon Sulfolobus solfataricus in relation to starch processing. |
| PubMed: | Purification and characterization of an intracellular cycloalternan-degrading enzyme from Bacillus sp. NRRL B-21195. |
| PubMed: | Production of palatinose using Serratia plymuthica cells immobilized in chitosan. |
| PubMed: | Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083. |
| PubMed: | Glucosylisomaltol, a new indicator of browning reaction in baby cereals and bread. |
| PubMed: | 13-Week oral toxicity study with isomaltulose (Palatinose) in rats. |
| PubMed: | Isomaltulose (Palatinose): a review of biological and toxicological studies. |
| PubMed: | Glucooligosaccharides from Leuconostoc mesenteroides B-742 (ATCC 13146): a potential prebiotic. |
| PubMed: | Potato tubers as bioreactors for palatinose production. |
| PubMed: | Cooperative action of alpha-glucanotransferase and maltogenic amylase for an improved process of isomaltooligosaccharide (IMO) production. |
| PubMed: | High-level production of the non-cariogenic sucrose isomer palatinose in transgenic tobacco plants strongly impairs development. |
| PubMed: | Use of isomalto-oligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients. |
| PubMed: | Assessment of acid production by various human oral micro-organisms when palatinose or leucrose is utilized. |
| PubMed: | Classification of Spanish Unifloral Honeys by Discriminant Analysis of Electrical Conductivity, Color, Water Content, Sugars, and pH. |
| PubMed: | Acceptor specificity of cellobiose phosphorylase from Cellvibrio gilvus: synthesis of three branched trisaccharides. |
| PubMed: | Protein engineering of Aspergillus awamori glucoamylase to increase its pH optimum. |
| PubMed: | Mutations to alter Aspergillus awamori glucoamylase selectivity. II. Mutation of residues 119 and 121. |
| PubMed: | Mutations to alter Aspergillus awamori glucoamylase selectivity. I. Tyr48Phe49-->Trp, Tyr116-->Trp, Tyr175-->Phe, Arg241-->Lys, Ser411-->Ala and Ser411-->Gly. |
| PubMed: | Embryotoxicity/teratogenicity study with isomaltulose (Palatinose) in rats. |
| PubMed: | The effects of isomaltulose-based oligomers feeding and calcium deficiency on mineral retention in rats. |
| PubMed: | Purification and characterization of alpha-glucosidase from Torulaspora pretoriensis YK-1. |
| PubMed: | Effects of conventional sucrose-based, fructose-based and isomalt-based chocolates on postprandial metabolism in non-insulin-dependent diabetics. |
| PubMed: | Binding of isomaltose and maltose to the glucoamylase from Aspergillus niger, as studied by fluorescence spectrophotometry and steady-state kinetics. |
| PubMed: | Single-villus analysis of disaccharidase expression by different regions of the mouse intestine. |
| PubMed: | Hydrolysis of alpha-D-glucopyranosyl-1,6-sorbitol and alpha-D-glucopyranosyl-1,6-mannitol by rat intestinal disaccharidases. |
| PubMed: | Charcoal column/thin layer chromatographic method for high fructose corn sirup and spectrophotometric method for hydroxymethylfurfural in honey: collaborative studies. |
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