ajoene, 92285-01-3

Articles:

PubMed:	Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples.
PubMed:	The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review.
PubMed:	The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells.
PubMed:	Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review.
PubMed:	The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens.
PubMed:	Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis.
PubMed:	Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic): A Review.
PubMed:	Natural compounds for pediatric cancer treatment.
PubMed:	ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma.
PubMed:	The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.
PubMed:	Virtual Screening of Natural and Synthetic Ligands Against Diabetic Retinopathy by Molecular Interaction With Angiopoietin-2.
PubMed:	Optimizing conditions for E-and Z-ajoene formation from garlic juice using response surface methodology.
PubMed:	Applications of thin-layer chromatography in extraction and characterisation of ajoene from garlic bulbs.
PubMed:	Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol.
PubMed:	Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent.
PubMed:	Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.
PubMed:	Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia.
PubMed:	Solid phase microextraction coupled to liquid chromatography. Analysis of organosulphur compounds avoiding artifacts formation.
PubMed:	Investigating the responses of Cronobacter sakazakii to garlic-drived organosulfur compounds: a systematic study of pathogenic-bacterium injury by use of high-throughput whole-transcriptome sequencing and confocal micro-raman spectroscopy.
PubMed:	Enhancement of intestinal IgA production by Ajoene in mice.
PubMed:	Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro.
PubMed:	Molecular mechanisms for the anti-cancer effects of diallyl disulfide.
PubMed:	A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in allium products as ideal agents: a review.
PubMed:	Garlic as an anti-diabetic agent: recent progress and patent reviews.
PubMed:	Anti-inflammatory activity of sulfur-containing compounds from garlic.
PubMed:	Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds.
PubMed:	Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation.
PubMed:	[In vitro synergisms among hydrazones, ajoeno and posaconazole against Cryptococcus spp].
PubMed:	A comprehensive review of vaginitis phytotherapy.
PubMed:	Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.
PubMed:	Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.
PubMed:	Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
PubMed:	[In vitro antifungal activity of ajoene on five clinical isolates of Histoplasma capsulatum var. capsulatum].
PubMed:	Potential beneficial effects of garlic in oncohematology.
PubMed:	Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines.
PubMed:	Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens.
PubMed:	Antithrombotic effects of naturally derived products on coagulation and platelet function.
PubMed:	Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.
PubMed:	Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.
PubMed:	Garlic-derived anticancer agents: structure and biological activity of ajoene.
PubMed:	Garlic derivatives (PTS and PTS-O) differently affect the ecology of swine faecal microbiota in vitro.
PubMed:	Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative.
PubMed:	[In vitro inhibitory effect of ajoene on Candida isolates recovered from vaginal discharges].
PubMed:	Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.
PubMed:	Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis.
PubMed:	Thermostability of allicin determined by chemical and biological assays.
PubMed:	Antifungal activity of ajoene on experimental murine paracoccidioidomycosis.
PubMed:	[Synergy between ajoene and ketoconazole in isolates of Microsporum canis. A preliminary study using fractional inhibitory concentration technique (FIC)].
PubMed:	Substituted ajoenes as novel anti-cancer agents.
PubMed:	Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.
PubMed:	Phytochemicals and regulation of the adipocyte life cycle.
PubMed:	[Activity of ajoene on dermatophytes, Candida albicans and Malassezia furfur.].
PubMed:	Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim.
PubMed:	Activities of Z-ajoene against tumour and viral spreading in vitro.
PubMed:	[Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro].
PubMed:	Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes.
PubMed:	Virucidal agents in the eve of manorapid synergy.
PubMed:	Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.
PubMed:	[Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent].
PubMed:	Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.
PubMed:	Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).
PubMed:	[Z-ajoene causes cell cycle arrest at G2/M and decrease of telomerase activity in HL-60 cells].
PubMed:	Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.
PubMed:	Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice.
PubMed:	Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibiotics.
PubMed:	Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes.
PubMed:	Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
PubMed:	[An ELISA test for the study of the therapeutic evolution of chromoblastomycosis by Cladophialophora carrionii in the endemic area of Falcon State, Venezuela].
PubMed:	Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability.
PubMed:	Beneficial effects of a polar fraction of garlic (Allium sativum Linn) oil in rats fed with two different high fat diets.
PubMed:	Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
PubMed:	Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice.
PubMed:	Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy.
PubMed:	Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.
PubMed:	Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin.
PubMed:	Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.
PubMed:	Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene.
PubMed:	Ajoene inhibits the activation of human endothelial cells induced by porcine cells: implications for xenotransplantation.
PubMed:	The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis.
PubMed:	Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.
PubMed:	The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).
PubMed:	Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.
PubMed:	Inhibition by ajoene of skin-tumor promotion in mice.
PubMed:	Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.
PubMed:	Antiproliferative and leishmanicidal effect of ajoene on various Leishmania species: ultrastructural study.
PubMed:	Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.
PubMed:	Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells.
PubMed:	Ajoene, an experimental anti-leukemic drug: mechanism of cell death.
PubMed:	Protective effect of ajoene on acetaminophen-induced hepatic injury in mice.
PubMed:	Garlic extract for HIV?
PubMed:	Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?
PubMed:	Thermochemical transformation of sulfur compounds in Japanese domestic Allium, Allium victorialis L.
PubMed:	Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine.
PubMed:	Structure-activity relationships for selected sulfur-rich antithrombotic compounds.
PubMed:	Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine.
PubMed:	An organosulfur compound isolated from oil-macerated garlic extract, and its antimicrobial effect.
PubMed:	Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.
PubMed:	Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanism.
PubMed:	Ajoene [(e,z)-4,5,9-trithiadodeca-1,6,11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations.
PubMed:	Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].
PubMed:	Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase.
PubMed:	Antimicrobial activity of a compound isolated from an oil-macerated garlic extract.
PubMed:	Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB.
PubMed:	[Effect of the garlic tablets allicor on thrombocyte aggregation in vitro and ex vivo].
PubMed:	Inhibition of Paracoccidioides brasiliensis by ajoene is associated with blockade of phosphatidylcholine biosynthesis.
PubMed:	Inhibition by ajoene of protein tyrosine phosphatase activity in human platelets.
PubMed:	Effects of Ajoene on lymphocyte and macrophage membrane-dependent functions.
PubMed:	In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].
PubMed:	Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites.
PubMed:	Antimutagenic effects of ajoene, an organosulfur compound derived from garlic.
PubMed:	Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic.
PubMed:	Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis.
PubMed:	Therapeutic actions of garlic constituents.
PubMed:	Synergistic effects of ajoene and the microwave power density memories of water on germination inhibition of fungal spores.
PubMed:	A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model.
PubMed:	Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells.
PubMed:	In vivo activity of ajoene against rodent malaria.
PubMed:	Injuries to cultivated BJA-B cells by ajoene, a garlic-derived natural compound: cell viability, glutathione metabolism, and pools of acidic amino acids.
PubMed:	Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets.
PubMed:	Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic.
PubMed:	Effect of ajoene on dimorphism of Paracoccidioides brasiliensis.
PubMed:	Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation.
PubMed:	In vitro virucidal effects of Allium sativum (garlic) extract and compounds.
PubMed:	Ajoene antagonizes integrin-dependent processes in HIV-infected T-lymphoblasts.
PubMed:	Kinetics of merthiolate-induced aggregation of human platelets.
PubMed:	Wine and coronary heart disease.
PubMed:	Functional implications of tyrosine protein phosphorylation in platelets. Simultaneous studies with different agonists and inhibitors.
PubMed:	Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic.
PubMed:	[Kinetics of merthiolate-induced aggregation of human platelets].
PubMed:	Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products.
PubMed:	Potassium channel activation in vascular smooth muscle.
PubMed:	[The ajoene blockade of integrin-dependent processes in an HIV-infected cell system].
PubMed:	Binding of aflatoxin B1 to DNA inhibited by ajoene and diallyl sulfide.
PubMed:	Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene.
PubMed:	Isolation and Identification of Homologues of Ajoene and Alliin from Bulb-Extracts of Allium ursinum.
PubMed:	[Formation of allicin from dried garlic (Allium sativum): a simple HPTLC method for simultaneous determination of allicin and ajoene in dried garlic and garlic preparations].
PubMed:	Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products.
PubMed:	Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro.
PubMed:	The role of adhesive interactions and extracellular matrix fibronectin from human polymorphonuclear leukocytes in the respiratory burst.
PubMed:	Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA binding of aflatoxin B1.
PubMed:	Potassium channel activation, hyperpolarization, and vascular relaxation.
PubMed:	The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines.
PubMed:	Products of Allicin Transformation: Ajoenes and Dithiins, Characterization and their Determination by HPLC*.
PubMed:	[Adhesion receptors--regulators of respiratory burst in neutrophils].
PubMed:	Ajoene prevents fat digestion by human gastric lipase in vitro.
PubMed:	Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.
PubMed:	Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity.
PubMed:	Interaction of antiaggregant molecule ajoene with membranes. An ESR and 1H, 2H, 31P-NMR study.
PubMed:	Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components.
PubMed:	Reversible prevention of platelet activation by (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide (ajoene) in dogs under extracorporeal circulation.
PubMed:	Ajoene inhibition of platelet aggregation: possible mediation by a hemoprotein.
PubMed:	Antifungal activity of ajoene derived from garlic.
PubMed:	The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor.
PubMed:	Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.