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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 73.00 to 76.00 °C. @ 12.00 mm Hg
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| Boiling Point: | 156.00 to 157.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 1.053000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 192.00 °F. TCC ( 88.89 °C. )
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| logP (o/w): | -0.739 (est) |
| Soluble in: |
| | alcohol | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for 4-hydroxy-2-butanone usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-hydroxy-2-butanone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-keto | butan-1-ol | | 3-oxo-1- | butanol | | 4- | hydroxybutan-2-one | | | methylol acetone | | mono- | methylol acetone |
Articles:
| PubMed: | Investigation of the Gas-Phase Photolysis and Temperature-Dependent OH Reaction Kinetics of 4-Hydroxy-2-butanone. |
| PubMed: | Asymmetric reduction of 4-hydroxy-2-butanone to (R)-1,3-butanediol with absolute stereochemical selectivity by a newly isolated strain of Pichia jadinii. |
| PubMed: | HS-SPME-GC-FID method for detection and quantification of Bacillus cereus ATCC 10702 mediated 2-acetyl-1-pyrroline. |
| PubMed: | First experimental determination of the absolute gas-phase rate coefficient for the reaction of OH with 4-hydroxy-2-butanone (4H2B) at 294 K by vapor pressure measurements of 4H2B. |
| PubMed: | Asymmetric synthesis of (R)-1,3-butanediol from 4-hydroxy-2-butanone by a newly isolated strain Candida krusei ZJB-09162. |
| PubMed: | Nanotube-supported bioproduction of 4-hydroxy-2-butanone via in situ cofactor regeneration. |
| PubMed: | Albumin-directed stereoselective reduction of 1,3-diketones and β-hydroxyketones to anti diols. |
| PubMed: | Design and synthesis of dually branched 5'-norcarbocyclic adenosine phosphonodiester analogue as a new anti-HIV prodrug. |
| PubMed: | Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol. |
| PubMed: | Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor: promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction. |
| PubMed: | Protonation thermochemistry of selected hydroxy- and methoxycarbonyl molecules. |
| PubMed: | Enhancing the synthetic utility of aldolase antibody 38C2. |
| PubMed: | Calculation of absolute protein-ligand binding affinity using path and endpoint approaches. |
| PubMed: | FTIR kinetic, product, and modeling study of the OH-initiated oxidation of 1-butanol in air. |
| PubMed: | Determination of alpha- and beta-hydroxycarbonyls and dicarbonyls in snow and rain samples by GC/FID and GC/MS employing benzyl hydroxyl oxime derivatization |
| PubMed: | Cloning and expression in Escherichia coli of a gene coding for a secondary alcohol dehydrogenase from Candida parapsilosis. |
| PubMed: | Purification and characterization of (S)-1,3-butanediol dehydrogenase from Candida parapsilosis. |
| PubMed: | Microbial Production of Optically Active 1,3-Butanediol from 4-Hydroxy-2-butanone. |
| PubMed: | The disposition of clavulanic acid in man. |
| PubMed: | High-performance liquid chromatographic assay of clavulanate in human plasma and urine by fluorimetric detection. |
| PubMed: | Absorption, metabolism and excretion studies on clavulanic acid in the rat and dog. |
| PubMed: | 4-Hydroxy-2-butanone Thiosemicarbazone, a Potential Anticancer Agent. |
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