epifriedelanol
(3S,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydro-3-picenol
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      16844-71-6 epifriedelanol 99%
      Epifriedelanol isolated from the herbs of Vitis trifolia. It suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts and human umbilical vein endothelial cells.
       
       
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CAS Number: 16844-71-6Picture of molecule3D/inchi
Nikkaji Web: J16.165I
XlogP3-AA: 10.10 (est)
Molecular Weight: 428.74364000
Formula: C30 H52 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 478.30 °C. @ 760.00 mm Hg (est)
Flash Point: 391.00 °F. TCC ( 199.60 °C. ) (est)
logP (o/w): 11.450 (est)
Soluble in:
 water, 7.845e-005 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Epifriedelanol 98%
BOC Sciences
For experimental / research use only.
epifriedelanol 99%
Odor: characteristic
Use: Epifriedelanol isolated from the herbs of Vitis trifolia. It suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts and human umbilical vein endothelial cells.
Coompo
For experimental / research use only.
EpiFriedelanol from Plants ≥96%
Odor: characteristic
Use: Epifriedelanol had inhibitory effects on adriamycin-induced cellular senescence in human fibroblasts (HDFs). Epifriedelanol suppressed adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). These results suggest that epifriedelanol reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol demonstrated antitumor activity in a potato disc bioassay.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for epifriedelanol usage levels up to:
 not for fragrance use.
 
Recommendation for epifriedelanol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 119242
National Institute of Allergy and Infectious Diseases: Data
 (3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol
Chemidplus: 0016844716
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References:
 (3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 119242
Pubchem (sid): 135074735
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C17123
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
epi-friedelanol
epifriedelinol
(3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol
(3S,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydro-3-picenol
(3S,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydropicen-3-ol
3-picenol, docosahydro-4,4a,6b,8a,11,11,12b,14a-octamethyl-, (3S,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-
(3beta,4beta,5beta,8alpha,9beta,10alpha,13alha,14beta)-5,9,13-trimethyl-24,25,26-trinoroleanan-3-ol
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Articles:
PubMed: A new cycloartane nortriterpenoid from stem and leaf of Quercus variabilis.
PubMed: Antimicrobial activity and cytotoxicity of triterpenes isolated from leaves of Maytenus undata (Celastraceae).
PubMed: Six new phenolic glycosides and a new ceramide from the flowers of Wedelia biflora and their cytotoxicity against some cancer cell lines.
PubMed: Phenolic contents, antioxidant and cytotoxic activities of Elaeocarpus floribundus Blume.
PubMed: [Study on chemical constituents from Anoectochilus chapaensis].
PubMed: A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae).
PubMed: Antiproliferative constituents of the roots of Conyza canadensis.
PubMed: Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum.
PubMed: Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.
PubMed: Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.
PubMed: [Chemical constituents of stem barks of Mucuna birdwoodiana].
PubMed: [Study on the chemical constituents of Humulus scandens].
PubMed: [Study on the chemical constituents of Dichrocephala integrifolia].
PubMed: Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells.
PubMed: [Studies on chemical constituents of leaves of Aquilaria sinensis].
PubMed: Composition of the epicuticular and intracuticular wax layers on Kalanchoe daigremontiana (Hamet et Perr. de la Bathie) leaves.
PubMed: [Studies on chemical constituents of aerial roots of Ficus microcarpa].
PubMed: Development of the cuticular wax during growth of Kalanchoe daigremontiana (Hamet et Perr. de la Bathie) leaves.
PubMed: New triterpenoids isolated from the root bark of Ulmus pumila L.
PubMed: Antitumor and antiinflammatory constituents from Celtis sinensis.
PubMed: Pentacyclic triterpenoids from Mallotus apelta.
PubMed: [Studies on the constituents from the herb of Vernonia patula].
PubMed: Antitumor activity of epifriedelanol from Vitis trifolia.
PubMed: [Chemical constituents of Parthenocissus thomsonii (Laws.) Planch].
PubMed: [Chemical constituents in the stem of Premna crassa Hand. -Mazz].
PubMed: Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis.
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