| PubMed: | The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway. |
| PubMed: | Flavonolignans reduce the response of blood platelet to collagen. |
| PubMed: | Flavonolignans inhibit the arachidonic acid pathway in blood platelets. |
| PubMed: | The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes. |
| PubMed: | Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells. |
| PubMed: | Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. |
| PubMed: | Effects of Potassium Sulfate [K2SO4] on The Element Contents, Polyphenol Content, Antioxidant and Antimicrobial Activities of Milk Thistle [Silybum Marianum]. |
| PubMed: | Effects of Silymarin on Diabetes Mellitus Complications: A Review. |
| PubMed: | Flavonolignans inhibit ADP induced blood platelets activation and aggregation in whole blood. |
| PubMed: | A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase. |
| PubMed: | Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom. |
| PubMed: | Silymarin content in Silybum marianum populations growing in Egypt. |
| PubMed: | Is Silybin the Best Free Radical Scavenger Compound in Silymarin? |
| PubMed: | Phototoxic potential of silymarin and its bioactive components. |
| PubMed: | Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts. |
| PubMed: | Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. |
| PubMed: | Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. |
| PubMed: | Supercritical CO₂ extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities in Caco-2 cells. |
| PubMed: | Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification/solvent evaporation method. |
| PubMed: | Accumulation of silymarin in milk thistle seeds under drought stress. |
| PubMed: | Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner. |
| PubMed: | Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II. |
| PubMed: | An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study. |
| PubMed: | An integrated proteomic approach to decipher the effect of methyl jasmonate elicitation on the proteome of Silybum marianum L. hairy roots. |
| PubMed: | Free Radical Scavenging and Antioxidant Activities of Silymarin Components. |
| PubMed: | Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy. |
| PubMed: | Absorption and metabolism of milk thistle flavanolignans in humans. |
| PubMed: | A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. |
| PubMed: | [Determination of active components in silymarin by UPLC-ESIMS]. |
| PubMed: | Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study. |
| PubMed: | Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro. |
| PubMed: | Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage. |
| PubMed: | Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry. |
| PubMed: | Enhanced production of silymarin by Ag+ elicitor in cell suspension cultures of Silybum marianum. |
| PubMed: | Milk thistle in liver diseases: past, present, future. |
| PubMed: | Topical delivery of silymarin constituents via the skin route. |
| PubMed: | Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum. |
| PubMed: | [Silymarin in the treatment of chronic liver diseases: past and future]. |
| PubMed: | Drug-drug interactions of silymarin on the perspective of pharmacokinetics. |
| PubMed: | Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). |
| PubMed: | Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. |
| PubMed: | Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. |
| PubMed: | Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF). |
| PubMed: | Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting. |
| PubMed: | Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. |
| PubMed: | Anticancer potential of silymarin: from bench to bed side. |
| PubMed: | Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. |
| PubMed: | Synthesis and antihepatotoxic activity of some new chalcones containing 1, 4 - dioxane ring system. |
| PubMed: | Silymarin and its components scavenge phenylglyoxylic ketyl radicals. |
| PubMed: | Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed: | Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. |
| PubMed: | Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. |
| PubMed: | An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. |
| PubMed: | Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. |
| PubMed: | A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). |
| PubMed: | Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans. |
| PubMed: | Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum). |
| PubMed: | Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents. |
| PubMed: | Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system. |
| PubMed: | Analysis of the active components of silymarin. |
| PubMed: | Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. |
| PubMed: | Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities. |
| PubMed: | Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS. |
| PubMed: | [Determination of the active flavonoids in silymarine]. |
| PubMed: | Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin. |
| PubMed: | Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans. |
| PubMed: | Determination of active component in silymarin by RP-LC and LC/MS. |
| PubMed: | [Separation and determination of effective components in silymarin and preparations of silymarin by MECC]. |
| PubMed: | Flavonolignan production from Silybum marianum transformed and untransformed root cultures. |
| PubMed: | Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. |
| PubMed: | Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro. |
| PubMed: | Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils. |
| PubMed: | Comparative pharmacokinetics of silipide and silymarin in rats. |
| PubMed: | Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. |
| PubMed: | [Effects of flavobion on nucleic acids in tissues of rats irradiated with gamma rays]. |
| PubMed: | Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. |
| PubMed: | [Milk thistle (Silybum marianum, L., Gaertn.) in the feed of ketotic cows]. |
| PubMed: | Advances in pharmacological studies of silymarin. |
| PubMed: | Silymarin: potent inhibitor of cyclic AMP phosphodiesterase. |
| PubMed: | [Structure of silandrin and silymonin, two new flavanolignans from a white blooming Silybum marianum variety]. |
| PubMed: | [Bioavailability of silymarin, I: Volumes of distribution of silybin, silydianin, and silychristin from in-vitro data (author's transl)]. |
| PubMed: | Silymarin, an inhibitor of prostaglandin synthetase. |
| PubMed: | Silymarin, an inhibitor of lipoxygenase. |
| PubMed: | [Changes in erythrocyte shape and volume caused by silymarin]. |
| PubMed: | [Peroxidase isoenzymes in cress seedlings (Lepidium sativum L.) and their inhibition by silybin, silydianin and silychristin]. |
| PubMed: | [Silymarin--an inhibitor of horseradish peroxidase (author's transl)]. |