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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 632.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 443.00 °F. TCC ( 228.50 °C. ) (est)
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| logP (o/w): | 2.161 (est) |
| Soluble in: |
| | water, 543.6 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for cleomiscosin A usage levels up to: | | | not for fragrance use.
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| Recommendation for cleomiscosin A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 100151 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one |
| Chemidplus: | 0076948726 |
References:
| | 3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 100151 |
| Pubchem (sid): | 135056504 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-(4- | hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one |
Articles:
| PubMed: | [Chemical constituents from stems of Brucea mollis and their cytotoxic activity]. |
| PubMed: | Chemical constituents of Allophylus longipes. |
| PubMed: | PPARγ agonist from Chromolaena odorata. |
| PubMed: | QSAR, docking and in vitro studies for anti-inflammatory activity of cleomiscosin A methyl ether derivatives. |
| PubMed: | [Chemical constituents of Datura stramonium seeds]. |
| PubMed: | Hepatoprotective Effects and Safety Evaluation of Coumarinolignoids Isolated from Cleome viscosa Seeds. |
| PubMed: | Chemical constituents from the roots of Xanthium sibiricum. |
| PubMed: | In silico exploration of anti-inflammatory activity of natural coumarinolignoids. |
| PubMed: | Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. |
| PubMed: | High-performance liquid chromatographic method for identification and quantification of three potent liver protective coumarinolignoids-cleomiscosin A, cleomiscosin B and cleomiscosin C-in extracts of Cleome viscosa. |
| PubMed: | Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest. |
| PubMed: | Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. |
| PubMed: | Repenins A-D, four new antioxidative coumarinolignoids from Duranta repens Linn. |
| PubMed: | Isolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis. |
| PubMed: | Identification and quantification of two antihepatotoxic coumarinolignoids cleomiscosin A and cleomiscosin B in the seeds of Cleome viscosa using liquid chromatography-tandem mass spectrometry. |
| PubMed: | High-performance liquid chromatography and LC-ESI-MS method for the identification and quantification of two biologically active isomeric coumarinolignoids cleomiscosin A and cleomiscosin B in different extracts of Cleome viscosa. |
| PubMed: | New hepatoprotective coumarinolignoids from Mallotus apelta. |
| PubMed: | [Chemical constituents from branch of Macaranga adenantha and their TNF-alpha inhibitory activity]. |
| PubMed: | High-performance liquid chromatographic method for identification and quantification of two isomeric coumarinolignoids-cleomiscosin A and cleomiscosin B-in extracts of Cleome viscosa. |
| PubMed: | Rare biscoumarins and a chlorogenic acid derivative from Erycibe obtusifolia. |
| PubMed: | Vasorelaxant effects of Acer nikoense extract and isolated coumarinolignans on rat aortic rings. |
| PubMed: | Chemical constituents from the roots of Homonoia riparia. |
| PubMed: | Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum. |
| PubMed: | Isolation of constituents and anti-complement activity from Acer okamotoanum. |
| PubMed: | Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyoscyamus niger. |
| PubMed: | New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells. |
| PubMed: | Inhibitory effect of coumarins from Weigela subsessilis on low density lipoprotein oxidation. |
| PubMed: | Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies. |
| PubMed: | [Studies on chemical constituents of Stelmatocrypton khasianum (Benth.) H. Bail]. |
| PubMed: | Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacus. |
| PubMed: | Coumarinolignoids of Mallotus apelta. |
| PubMed: | A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells. |
| PubMed: | Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica. |
| PubMed: | Plant anticancer agents XXIX. Cleomiscosin A from Simaba multiflora, Soulamea soulameoides, and Matayba arborescens. |
| PubMed: | Plant anticancer agents XXV. Constituents of Soulamea soulameoides. |
| PubMed: | Plant anticancer agents. XXIV. Alkaloid constituents of Simaba multiflora. |
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