arctigenin, 7770-78-7

Articles:

PubMed:	Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway.
PubMed:	Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase.
PubMed:	Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling.
PubMed:	Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration.
PubMed:	Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling.
PubMed:	Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
PubMed:	[Protective effect of arctigenin in GK rats combined with hypertension macroangiopathy].
PubMed:	The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes.
PubMed:	Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling.
PubMed:	PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin.
PubMed:	Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling.
PubMed:	Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes.
PubMed:	Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways.
PubMed:	Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM.
PubMed:	Design and synthesis of novel arctigenin analogues for the amelioration of metabolic disorders.
PubMed:	Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression.
PubMed:	Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.
PubMed:	The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway.
PubMed:	Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography.
PubMed:	Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.
PubMed:	[Suppression of VEGF protein expression by arctigenin in oral squamous cell carcinoma].
PubMed:	Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium.
PubMed:	Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin.
PubMed:	Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study.
PubMed:	Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway.
PubMed:	Extensive intestinal first-pass metabolism of arctigenin: evidenced by simultaneous monitoring of both parent drug and its major metabolites.
PubMed:	Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
PubMed:	Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.
PubMed:	Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells.
PubMed:	Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages.
PubMed:	Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.
PubMed:	Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin.
PubMed:	Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration.
PubMed:	Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels.
PubMed:	Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling.
PubMed:	Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers.
PubMed:	Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines.
PubMed:	Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity.
PubMed:	[Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration].
PubMed:	Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.
PubMed:	Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.
PubMed:	(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β.
PubMed:	Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway.
PubMed:	Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.
PubMed:	Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells.
PubMed:	Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.
PubMed:	Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages.
PubMed:	Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.
PubMed:	Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.
PubMed:	Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin.
PubMed:	Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method.
PubMed:	Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats.
PubMed:	Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression.
PubMed:	Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721.
PubMed:	Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation.
PubMed:	Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial-mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithelial cells.
PubMed:	Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha.
PubMed:	Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells.
PubMed:	Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway.
PubMed:	Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
PubMed:	Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells.
PubMed:	[Research on the preparative method of Arctigenin].
PubMed:	(-)-Arctigenin as a lead compound for anticancer agent.
PubMed:	Inhibitory effect of arctigenin on lymphocyte activation stimulated with PMA/ionomycin.
PubMed:	Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.
PubMed:	Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
PubMed:	Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry.
PubMed:	Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin.
PubMed:	Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
PubMed:	Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.
PubMed:	Arctigenin alleviates ER stress via activating AMPK.
PubMed:	Synthesis of (-)-arctigenin derivatives and their anticancer activity.
PubMed:	Arctigenin efficiently enhanced sedentary mice treadmill endurance.
PubMed:	Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes.
PubMed:	Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.
PubMed:	Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes.
PubMed:	Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity.
PubMed:	In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway.
PubMed:	Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
PubMed:	Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan.
PubMed:	Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.
PubMed:	pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system.
PubMed:	Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
PubMed:	Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: their gas and liquid chromatographic analysis in plant extracts.
PubMed:	New expectations from the well-known medicinal properties of Arctium lappa.
PubMed:	Anti-inflammatory activity of arctigenin from Forsythiae Fructus.
PubMed:	Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations.
PubMed:	Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation.
PubMed:	[Effect of anti-influenza virus of Arctigenin in vivo].
PubMed:	Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells.
PubMed:	Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
PubMed:	Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC.
PubMed:	Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.
PubMed:	A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography.
PubMed:	Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS.
PubMed:	Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
PubMed:	Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
PubMed:	Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling.
PubMed:	[Induction of apoptosis of the human leukemia cells by arctigenin and its mechanism of action].
PubMed:	Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid.
PubMed:	(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
PubMed:	Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
PubMed:	Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products.
PubMed:	Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.
PubMed:	Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta.
PubMed:	Three new lignans from the seeds of Saussurea involucrata.
PubMed:	Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods.
PubMed:	Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.
PubMed:	Phytochemical profile and apoptotic activity of Onopordum cynarocephalum.
PubMed:	Tumour-growth inhibiting substances of plant origin. II. The experimental animal tumour-pharmacology of arctigenin-mustard.
PubMed:	Chemical analysis of raw and processed Fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass spectrometry.
PubMed:	Arctigenin: a lignan from Arctium lappa.
PubMed:	Active components with inhibitory activities on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways from Caulis Trachelospermi.
PubMed:	Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?
PubMed:	Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
PubMed:	Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
PubMed:	Steroidal esters from Ferula sinkiangensis.
PubMed:	Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan.
PubMed:	Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.
PubMed:	Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.
PubMed:	Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.
PubMed:	Optimization of the processing technology of Fructus Arctii by response surface methodology.
PubMed:	Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii.
PubMed:	Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection.
PubMed:	Cytotoxic components of bardanae fructus (goboshi).
PubMed:	Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds.
PubMed:	Seasonal alteration in amounts of lignans and their glucosides and gene expression of the relevant biosynthetic enzymes in the Forsythia suspense leaf.
PubMed:	Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 cells.
PubMed:	Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection.
PubMed:	New guaian-type sesquiterpene from Wikstroemia indica.
PubMed:	Simultaneous determination of five bioactive secolignans in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Peperomia dindygulensis Miq. extract.
PubMed:	Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
PubMed:	Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils.
PubMed:	[Anti-inflammatory mechanism of qingfei xiaoyan wan studied with network pharmacology].
PubMed:	Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.
PubMed:	Anti-austeric activity of phenolic constituents of seeds of Arctium lappa.
PubMed:	Induction of caspase-8 and death receptors by a new dammarane skeleton from the dried fruits of Forsythia koreana.
PubMed:	Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.
PubMed:	Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan.
PubMed:	The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.
PubMed:	Ion-sparing diuresis by 2,3-dibenzylbutane-1,4-diol, a synthetic mammalian-lignan derivative.
PubMed:	[Trace chemical constituents contained in Trachelospermum jasminoides and structure identification].
PubMed:	Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs.
PubMed:	Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.
PubMed:	Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1.
PubMed:	Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.
PubMed:	Differential in vitro anti-HIV activity of natural lignans.
PubMed:	Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts.
PubMed:	Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.
PubMed:	[A comparative research on quality of Vitmin C Yinqiao tablets from different manufacturers].
PubMed:	[Dyuamical studies on metabolic chemistry of lignans from seeds of Arctium lappa].
PubMed:	[Constituents of Gymnadenia conopsea].
PubMed:	Evaluation of estrogen receptor Beta binding of pruni cortex and its constituents.
PubMed:	Application of gradient-enhanced nuclear Overhauser effect spectroscopy GOESY) in the structure elucidation of plant secondary metabolites.
PubMed:	Cytotoxic activity of Ipomoea cairica.
PubMed:	Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses.
PubMed:	Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells.
PubMed:	Hepatoprotective dibenzylbutyrolactone lignans of Torreya nucifera against CCl4-induced toxicity in primary cultured rat hepatocytes.
PubMed:	In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol.
PubMed:	Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells.
PubMed:	Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India.
PubMed:	Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana.
PubMed:	Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells.
PubMed:	Sesquiterpene lactones from Centaurea tweediei.
PubMed:	Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.
PubMed:	Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2).
PubMed:	[Chemical components of Trachelospelmun jasminoides (Lindl.) Lem. var. heterophyllum Tsiang].
PubMed:	Structural transformation of lignan compounds in rat gastrointestinal tract.
PubMed:	Lignans and Other Constituents of Centaurea sphaerocephala ssp. polyacantha.
PubMed:	alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).
PubMed:	Assessing exposure to lignans and their metabolites in humans.
PubMed:	Lignans from Saussurea conica and their NO production suppressing activity.
PubMed:	A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.
PubMed:	Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria.
PubMed:	Stereochemical diversity in lignan biosynthesis of Arctium lappa L.
PubMed:	Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera.
PubMed:	Arctiin and onopordopicrin from Carduus micropterus ssp. perspinosus.
PubMed:	Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
PubMed:	Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.
PubMed:	Constituents of the Egyptian Centaurea scoparia. III. Phenolic constituents of the aerial parts.
PubMed:	[Studies on the chemical constituents of Arctium lappa L].
PubMed:	A Contribution to the Phytochemistry of Zanthoxylum tessmannii1.