4-hydroxyhexenal, 17427-08-6

Articles:

PubMed:	Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.
PubMed:	Noninvasive detection of lung cancer using exhaled breath.
PubMed:	Accumulation of hydroxyl lipids and 4-hydroxy-2-hexenal in live fish infected with fish diseases.
PubMed:	4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs.
PubMed:	Correction: Paricalcitol Attenuates 4-Hydroxy-2-Hexenal-Induced Inflammation and Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Epithelial Cells.
PubMed:	Re-assessing the mechanism of action of n-3 PUFAs.
PubMed:	4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.
PubMed:	Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition.
PubMed:	Exercise facilitates the action of dietary DHA on functional recovery after brain trauma.
PubMed:	Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?
PubMed:	4-hydroxyhexenal- and 4-hydroxynonenal-modified proteins in pterygia.
PubMed:	High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner.
PubMed:	Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells.
PubMed:	The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
PubMed:	Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice.
PubMed:	Mutagenic/recombinogenic effects of four lipid peroxidation products in Drosophila.
PubMed:	Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells.
PubMed:	A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids.
PubMed:	4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures.
PubMed:	Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial.
PubMed:	Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner.
PubMed:	Immunohistochemical detection of polyunsaturated fatty acid oxidation markers in acetaminophen-induced liver injury in rats.
PubMed:	Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids.
PubMed:	Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.
PubMed:	4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells.
PubMed:	Genotoxic analysis of four lipid-peroxidation products in the mouse lymphoma assay.
PubMed:	Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction.
PubMed:	Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.
PubMed:	Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.
PubMed:	Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.
PubMed:	Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression.
PubMed:	Fate in digestion in vitro of several food components, including some toxic compounds coming from omega-3 and omega-6 lipids.
PubMed:	Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells.
PubMed:	Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.
PubMed:	Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).
PubMed:	Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells.
PubMed:	Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE...
PubMed:	Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex.
PubMed:	Effects of Lipid Peroxidation-Derived Products on the Growth of Human Colorectal Cancer Cell Line HT-29.
PubMed:	Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury.
PubMed:	High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration.
PubMed:	Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions.
PubMed:	Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk--a preliminary study.
PubMed:	The effects of NaCl on lipid peroxidation-derived aldehyde, 4-hydroxy-2-hexenal formation in boiled yellowtail meat.
PubMed:	Immunohistochemical analysis of aldehyde-modified proteins in drusen in cynomolgus monkeys (Macaca fascicularis).
PubMed:	Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice.
PubMed:	Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.
PubMed:	Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation.
PubMed:	Aberrant expression of selenoproteins in the progression of colorectal cancer.
PubMed:	4-hydroxy-2-alkenals in polyunsaturated fatty acids-fortified infant formulas and other commercial food products.
PubMed:	Formaldehyde-protein conjugate-specific antibodies in rats exposed to formaldehyde.
PubMed:	Protective effect of TEMPOL derivatives against light-induced retinal damage in rats.
PubMed:	Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates.
PubMed:	Effects of NaCl on 4-hydroxy-2-hexenal formation in yellowtail meat stored at 0 degrees C.
PubMed:	Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites.
PubMed:	Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.
PubMed:	Effect of bleeding on hemoglobin contents and lipid oxidation in the skipjack muscle.
PubMed:	Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis.
PubMed:	Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.
PubMed:	Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containing n-3 and n-6 polyunsaturated fatty acids.
PubMed:	Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice.
PubMed:	In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis.
PubMed:	Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.
PubMed:	Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells.
PubMed:	Reduced effect on apoptosis of 4-hydroxyhexenal and oxidized LDL enriched with n-3 fatty acids from postmenopausal women.
PubMed:	Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation.
PubMed:	Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis.
PubMed:	Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation.
PubMed:	NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway.
PubMed:	Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.
PubMed:	Induction of endothelial apoptosis by 4-hydroxyhexenal.
PubMed:	Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids.
PubMed:	Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids.
PubMed:	Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction.
PubMed:	Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).
PubMed:	Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry.
PubMed:	Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses.
PubMed:	The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes.
PubMed:	Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells.
PubMed:	N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid peroxidation.
PubMed:	Enrichment of eggs with n-3 polyunsaturated fatty acids: effects of vitamin E supplementation.
PubMed:	Involvement of lipid peroxidation in spontaneous pancreatitis in WBN/Kob rats.
PubMed:	Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells.
PubMed:	Formation of 4-hydroxy-2-alkenals in barley leaves.
PubMed:	Lipid peroxidation and the oxidative burst associated with infection of capsicum annuum by botrytis cinerea
PubMed:	Tandem mass spectrometry of model peptides modified with trans-2-hexenal, a product of lipid peroxidation.
PubMed:	Formation of lipoxygenase-pathway-derived aldehydes in barley leaves upon methyl jasmonate treatment.
PubMed:	Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase.
PubMed:	Facile and general method for preparation of (E)-4-hydroxy-2-alkenals.
PubMed:	Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by 4-hydroxy-2-nonenal.
PubMed:	Oxygenation of (3Z)-alkenal to (2E)-4-hydroxy-2-alkenal in soybean seed (Glycine max L.).
PubMed:	Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins.
PubMed:	Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages.
PubMed:	4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition.
PubMed:	Hydroxyalkenal formation induced by advanced glycosylation of low density lipoprotein.
PubMed:	Inhibition of adenine nucleotide translocator by lipid peroxidation products.
PubMed:	Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins.
PubMed:	The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct.
PubMed:	Quantitative measurement of 4-hydroxyalkenals in oxidized low-density lipoprotein by gas chromatography-mass spectrometry.
PubMed:	Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes.
PubMed:	4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells.
PubMed:	Oxygenation of (3Z)-nonenal to (2E)-4-hydroxy-2-nonenal in the broad bean (Vicia faba L.).
PubMed:	Analysis of mercapturic acid conjugates of xenobiotic compounds using negative ionization and tandem mass spectrometry.
PubMed:	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
PubMed:	Effect of 4-hydroxylalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C.
PubMed:	4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid.
PubMed:	Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein.
PubMed:	Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes.
PubMed:	Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals.
PubMed:	Distribution of trans-4-hydroxy-2-hexenal and tandem mass spectrometric detection of its urinary mercapturic acid in the rat.
PubMed:	Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.
PubMed:	In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450.
PubMed:	Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2-hexenal.
PubMed:	2,3,7,8-Tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase pp60c-src.
PubMed:	Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.
PubMed:	Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes.
PubMed:	Metabolism of the pyrrolizidine alkaloid metabolite trans-4-hydroxy-2-hexenal by mouse liver aldehyde dehydrogenases.
PubMed:	In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules.
PubMed:	trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine.