ethyl icosapentate
ethyl (all cis)-5,8,11,14,17-icosapentaenoate
 
Notes:
Isol. from fish oils
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CAS Number: 73310-10-8Picture of molecule3D/inchi
FDA UNII: 6GC8A4PAYH
XlogP3-AA: 6.30 (est)
Molecular Weight: 330.51138000
Formula: C22 H34 O2
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.0003466 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Sigma-Aldrich
For experimental / research use only.
Eicosapentaenoic acid ethyl ester European Pharmacopoeia (EP) Reference Standard
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  > 20000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

oral-mouse LD50  > 20000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

intraperitoneal-rat LD50  15000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

oral-rat LD50  > 20000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 > 20000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

subcutaneous-rat LD50 > 20000 mg/kg
Yakkyoku. Pharmacy. Vol. 41, Pg. 1621, 1990.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for ethyl icosapentate usage levels up to:
 not for fragrance use.
 
Recommendation for ethyl icosapentate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9831415
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
Chemidplus: 0073310108
RTECS: JX3835000 for cas# 73310-10-8
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References:
 ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 9831415
Pubchem (cas): 73310-10-8
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C16184
HMDB (The Human Metabolome Database): HMDB39530
FooDB: FDB019145
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 fish oil
Search  PMC Picture
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Synonyms:
 eicosapentaenoic acid ethyl ester
 ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
 ethyl (all cis)-5,8,11,14,17-icosapentaenoate
 ethyl eicosapentaenoic acid
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Articles:
PubMed: Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA).
PubMed: The NMatrix, a new method of presenting statistics, displays the characteristics of medicines with similar effects used in the treatment of lumbar spinal stenosis concisely and clearly, facilitating the selection of appropriate medications.
PubMed: Aspirin- and clopidogrel-associated bleeding complications: data mining of the public version of the FDA adverse event reporting system, AERS.
PubMed: Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol.
PubMed: [A case of type 2 diabetes mellitus associated with familial hypercholesterolemia confirming the improvement of blood glucose control by colestimide].
PubMed: [A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs].
PubMed: Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty.
PubMed: Resolution of typical lipoprotein glomerulopathy by intensive lipid-lowering therapy.
PubMed: Lipid-lowering therapy and coagulation/fibrinolysis parameters in patients on peritoneal dialysis.
PubMed: [A 50-year history of new drugs in Japan: the developments and trends of antihyperlipidemic drugs].
PubMed: Effect of ethyl icosapentate on urinary calcium and oxalate excretion.
PubMed: Eicosapentaenoic acid effect on hyperlipidemia in menopausal Japanese women. The Niigata Epadel Study Group.
PubMed: Eicosapentaenoic acid stimulates nitric oxide production and decreases cardiac noradrenaline in diabetic rats.
PubMed: [Anti-hyperlipidemic drug].
PubMed: Evaluation of ethyl icosapentate in the treatment of hypercholesterolemia in kidney transplant recipients.
PubMed: Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis.
PubMed: [Blood rheological study in rats with fatty liver--with special reference to effects of ethyl icosapentate].
PubMed: Effect of ethyl icosapentate on urinary calcium excretion in calcium oxalate stone formers.
PubMed: Chemical stability of ethyl icosapentate against autoxidation. II. Effect of photoirradiation on oxidation kinetics.
PubMed: [Large scale multicenter cooperative study for cardiovascular therapy (Japan Multicenter Investigation for Cardiovascular Drugs/Therapies, J-MIC)--results and perspectives].
PubMed: Chemical stability of ethyl icosapentate against autoxidation. I. Effect of temperature on oxidation kinetics.
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