yangonin, 500-62-9

Articles:

PubMed:	Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage.
PubMed:	Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand.
PubMed:	Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit.
PubMed:	Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice.
PubMed:	Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
PubMed:	Proposal for a kava quality standardization code.
PubMed:	Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
PubMed:	Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
PubMed:	Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation.
PubMed:	Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
PubMed:	Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
PubMed:	Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation.
PubMed:	Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones.
PubMed:	Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
PubMed:	Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
PubMed:	Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
PubMed:	Determination of kava lactones in food supplements by liquid chromatography-atmospheric pressure chemical ionisation tandem mass spectrometry.
PubMed:	Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
PubMed:	LC-UV and LC-MS analysis of food and drink products containing kava.
PubMed:	Analysis of kavalactones from Piper methysticum (kava-kava).
PubMed:	Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.
PubMed:	Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
PubMed:	Kava does not display metabolic toxicity in a homogeneous cellular assay.
PubMed:	In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.
PubMed:	Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum).
PubMed:	Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products.
PubMed:	Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots.
PubMed:	Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst.
PubMed:	Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
PubMed:	Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm.
PubMed:	Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava).
PubMed:	Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats.
PubMed:	Influence of genuine kavapyrone enantiomers on the GABA-A binding site.
PubMed:	Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.
PubMed:	Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract.
PubMed:	Piper methysticum: enantiomeric separation of kavapyrones by high performance liquid chromatography.
PubMed:	Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.
PubMed:	Identification of some human urinary metabolites of the intoxicating beverage kava.
PubMed:	Uptake into mouse brain of four compounds present in the psychoactive beverage kava.
PubMed:	Metabolism of some kava pyrones in the rat.
PubMed:	[Quantitative determination of kawa lactones in Piper methysticum (Forster). 2. Determination of kawain, methysticin and yangonin].
PubMed:	[Quantitative determination of kawa-lactones in Piper methysticum (Forster). 1. Determination methods with pure substances kawain, methysticin and yangonin].
PubMed:	[Yangonin-a pharmacologically active pyran compound from Piper methysticum Forst].
PubMed:	[11-methoxy-nor-yangonin from botanically undescribed piper plant species from New Guinea].
PubMed:	[Isolation of 11-methoxy-yangonin from the cava root].