saussurea lappa root extract
extract of the roots of the costus, saussurea lappa, asteraceae
 
Notes:
None found
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Name: saussurea lappa extract
CAS Number: 90106-55-1 
ECHA EC Number: 290-278-1
Category: cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
AuNutra® Industries
Sanssurea P.E.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
IFRA Critical Effect: Dermal sensitization
IFRA: View Standard
Recommendation for saussurea lappa root extract usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Recommendation for saussurea lappa root extract flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 saussurea lappa extract
Chemidplus: 0090106551
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References:
 saussurea lappa extract
Pubchem (sid): 135309294
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 costus root
Search Trop  Picture
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Synonyms:
 aucklandia costus root extract
 costus root extract
 extract of the roots of the costus, saussurea lappa, asteraceae
 saussurea costus root extract
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Articles:
PubMed: UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa.
PubMed: Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India.
PubMed: Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens.
PubMed: Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats.
PubMed: Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells.
PubMed: Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.).
PubMed: Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.
PubMed: Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
PubMed: A new sesquiterpene and other constituents from Saussurea lappa root.
PubMed: Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice.
PubMed: Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa.
PubMed: Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing.
PubMed: Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma).
PubMed: Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm.
PubMed: Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
PubMed: Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.
PubMed: Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
PubMed: Germacrenes from fresh costus roots.
PubMed: Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release.
PubMed: Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line.
PubMed: Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice.
PubMed: Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase.
PubMed: Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
PubMed: Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix.
PubMed: Sesquiterpenoids from costum root oil (Saussurea lappa Clarke)
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