euphorbia tirucalli extract
africanmilkbush extract
 
Notes:
None found
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Name: euphorbia tirucalli l. extract
CAS Number: 93348-17-5 
ECHA EC Number: 297-157-2
Category: information only not used for fragrances or flavors
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  1000 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemical and Pharmaceutical Bulletin. Vol. 13, Pg. 882, 1965.

intraperitoneal-rat LD  > 30000 mg/kg
Journal of Toxicology and Environmental Health. Vol. 1, Pg. 939, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for euphorbia tirucalli extract usage levels up to:
 not for fragrance use.
 
Recommendation for euphorbia tirucalli extract flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
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EPA ACToR: Toxicology Data
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National Institute of Allergy and Infectious Diseases: Data
 euphorbia tirucalli l. extract
Chemidplus: 0093348175
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References:
 euphorbia tirucalli l. extract
Pubchem (sid): 135302606
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 euphorbia tirucalli
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Synonyms:
 milk hedge extract
africanmilkbush extract
 sher extract
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Articles:
PubMed: Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.
PubMed: β-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the π-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade.
PubMed: Eutirucallin, a RIP-2 type lectin from the latex of Euphorbia tirucalli L. presents proinflammatory properties.
PubMed: Gastric healing process with raw extract of Euphorbia tirucalli L.: study in rats.
PubMed: Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L.
PubMed: Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice.
PubMed: Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.
PubMed: Euphorbia tirucalli L.-comprehensive characterization of a drought tolerant plant with a potential as biofuel source.
PubMed: Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.
PubMed: The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.
PubMed: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.
PubMed: EBV Reactivation and Chromosomal Polysomies: Euphorbia tirucalli as a Possible Cofactor in Endemic Burkitt Lymphoma.
PubMed: Preventive and therapeutic euphol treatment attenuates experimental colitis in mice.
PubMed: Impact of Taraxerol in combination with extract of Euphorbia tirucalli plant on biological parameters of Lymnaea acuminata.
PubMed: Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach.
PubMed: Laticifer proteins play a defensive role against hemibiotrophic and necrotrophic phytopathogens.
PubMed: Toxicity of aqueous extract of Euphorbia tirucalli latex on catfish, Heteropneustes fossilis.
PubMed: New promising Euphorbiaceae extracts with activity in human lymphocytes from primary cell cultures.
PubMed: Effect of inganen anticancer properties on microtobule organization.
PubMed: Agrobacterium-mediated transformation of Euphorbia tirucalli callus.
PubMed: Potential of laticifer fluids for inhibiting Aedes aegypti larval development: evidence for the involvement of proteolytic activity.
PubMed: Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus.
PubMed: Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L.
PubMed: Larvicidal activity of some Euphorbiaceae plant extracts against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae).
PubMed: A case of acute keratoconjunctivitis from exposure to latex of Euphorbia tirucalli (pencil cactus).
PubMed: Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli.
PubMed: Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli.
PubMed: Toxicological screening of Euphorbia tirucalli L.: developmental toxicity studies in rats.
PubMed: Biochemical stress response in freshwater fish Channa punctatus induced by aqueous extracts of Euphorbia tirucalli plant.
PubMed: Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice.
PubMed: Alterations in carbohydrates and the protein metabolism of the harmful freshwater vector snail Lymnaea acuminata induced by the Euphorbia tirucalli latex extract.
PubMed: Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L.
PubMed: Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?
PubMed: Plants used for poison fishing in tropical Africa.
PubMed: Ocular injuries from plant sap of genera Euphorbia and Dieffenbachia.
PubMed: Larvicidal activity of latex and stem bark of Euphorbia tirucalli plant on the mosquito Culex quinquefasciatus.
PubMed: Activation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli.
PubMed: Cryptic dysfunction of cellular immunity in asymptomatic human immunodeficiency virus (HIV) carriers and its actualization by an environmental immunosuppressive factor.
PubMed: African Burkitt's lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity.
PubMed: Are plant factors a missing link in the evolution of endemic Burkitt's lymphoma?
PubMed: Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.
PubMed: Euphorcinol: A New Pentacyclic Triterpene from Euphorbia tirucalli.
PubMed: Further Triterpenes from the Stem Bark of Euphorbia tirucalli.
PubMed: African Burkitt's lymphoma and an Epstein-Barr virus-enhancing plant Euphorbia tirucalli.
PubMed: Epstein-Barr virus-enhancing plant promoters in east Africa.
PubMed: On the active principles of the Euphorbiaceae, XII. Highly unsaturated irritant diterpene esters from Euphorbia tirucalli originating from Madagascar.
PubMed: Molluscicide activity of the "avelós" plant (Euphorbia tirucalli, L.) on Biomphalaria glabrata, the mollusc vector of schistosomiasis.
PubMed: On the active principles of the spurge family (Euphorbiaceae). XI. [1] The skin irritant and tumor promoting diterpene esters of Euphorbia tirucalli L. originating from South Africa.
PubMed: Oil body formation in Euphorbia tirucalli L. cell suspension cultures.
PubMed: Chemical constituents of cultured cells of Euphorbia tirucalli and E. millii.
PubMed: Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells.
PubMed: Characterization of an irritant 4-deoxyphorbol diester from Euphorbia tirucalli.
PubMed: New highly irritant euphorbia factors from latex of Euphorbia tirucalli L.
PubMed: Dose-response in tumour-promotion by Euphorbia tirucalli latex.
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