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Category: stabilizing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 97.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 309.60 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point: | 311.00 °F. TCC ( 155.20 °C. ) (est)
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| logP (o/w): | -1.721 (est) |
| Soluble in: |
| | water, 333000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 1724 mg/kg GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intravenous-rabbit LD50 418 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intravenous-mouse LD50 71 mg/kg GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intraperitoneal-mouse LD50 1771 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 2580 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 852, 1965.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | stabilizing agents |
| Recommendation for disodium citrate usage levels up to: | | | not for fragrance use.
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| Recommendation for disodium citrate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 144-33-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8950 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | disodium 3-carboxy-3-hydroxypentanedioate |
| Chemidplus: | 0000144332 |
| RTECS: | GE7580000 for cas# 144-33-2 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | alkacitron | | | citralka | | | citric acid disodium salt | | | citric acid, disodium salt | | | disodium 2-(carboxymethyl)-2-hydroxysuccinate | | | disodium 2-hydroxy-1,2,3-propane tricarboxylate | | | disodium 2-hydroxy-1,2,3-propanetricarboxylate | | | disodium 3-carboxy-3-hydroxypentanedioate | | | disodium hydrogen citrate | | | disodium monohydrogen citrate | | | hydrogen sodium 2-hydroxypropane-1,2,3-tricarboxylate (1:2:1) | | 2- | hydroxy-1,2,3-propanetricarboxylic acid disodium salt | | 1,2,3- | propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2) | | 1,2,3- | propanetricarboxylic acid, 2-hydroxy-, disodium salt | | 1,2,3- | propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2) |
Articles:
| PubMed: | Multiple long-term, experimentally-evolved populations of Escherichia coli acquire dependence upon citrate as an iron chelator for optimal growth on glucose. |
| PubMed: | Chiroptical spectroscopy of natural products: avoiding the aggregation effects of chiral carboxylic acids. |
| PubMed: | Production of microbial cellulose by a bacterium isolated from fruit. |
| PubMed: | Influence of mixtures of calcium-chelating salts on the physicochemical properties of casein micelles. |
| PubMed: | Analysis of pesticides residues in fresh produce using buffered acetonitrile extraction and aminopropyl cleanup with gas chromatography/triple quadrupole mass spectrometry, liquid chromatography/triple quadrupole mass spectrometry, gas chromatography/ion trap detector mass spectrometry, and GC with a halogen-specific detector. |
| PubMed: | Extraction, partial characterization, and storage stability of β-glucosidase from propolis. |
| PubMed: | Toward an understanding of the salting-out effects in aqueous ionic liquid solutions: vapor-liquid equilibria, liquid-liquid equilibria, volumetric, compressibility, and conductivity behavior. |
| PubMed: | Microfluidic formation of ionically cross-linked polyamine gels. |
| PubMed: | Preparation of icariside II from icariin by enzymatic hydrolysis method. |
| PubMed: | Effects of pH on the textural properties and meltability of pasteurized process cheese made with different types of emulsifying salts. |
| PubMed: | Extractive spectrophotometric determination of TRODAT-1 hydrochloride in lyophilized kit. |
| PubMed: | Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria. |
| PubMed: | Effects of phosphates and citrates on sediment formation in UHT goats' milk. |
| PubMed: | Synthesis of tetracalcium phosphate from mechanochemically activated reactants and assessment as a component of bone cements. |
| PubMed: | An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies. |
| PubMed: | Desorption of copper and cadmium from soils enhanced by organic acids. |
| PubMed: | Effects of additives on the rheological properties and injectability of a calcium phosphate bone substitute material. |
| PubMed: | Effects of emulsifying salts on the turbidity and calcium-phosphate-protein interactions in casein micelles. |
| PubMed: | [Determination of trace cobalt in water samples by graphite furnace atomic absorption spectrometry after cloud point]. |
| PubMed: | Extraction behavior of metallic contaminants and soil constituents from contaminated soils. |
| PubMed: | Identification of factors involved in recovery of heat-injured Salmonella Enteritidis. |
| PubMed: | Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets. |
| PubMed: | Regional citrate anticoagulation in continuous venovenous haemodiafiltration using commercial solutions. |
| PubMed: | Influence of EDTA and citrate on physicochemical properties of whey protein-stabilized oil-in-water emulsions containing CaCl2. |
| PubMed: | Alkaline CPD and the preservation of RBC 2,3-DPG. |
| PubMed: | Intravenous tolerability of an acid vehicle in Sprague Dawley rats and beagle dogs after daily slow bolus injection and infusion for one hour during 14 days. |
| PubMed: | Effect of salt form on chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms. |
| PubMed: | Heat resistance of Bacillus cereus spores: effects of milk constituents and stabilizing additives. |
| PubMed: | Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms. |
| PubMed: | Determination of heterocyclic amines in flame-grilled fish patty by capillary electrophoresis. |
| PubMed: | In vivo viability studies of two additive solutions in the postthaw preservation of red cells held for 3 weeks at 4 degrees C. |
| PubMed: | Quantification of human amniotic fluid constituents by high resolution proton nuclear magnetic resonance (NMR) spectroscopy. |
| PubMed: | Importance of extracellular divalent cations to polarisation of polymorphonuclear leukocytes induced by plasma. |
| PubMed: | Residues in fish exposed to sublethal doses of endosulfan and fish collected from cotton growing area. |
| PubMed: | One-step extraction and cleanup procedure for determination of p,p'-DDT, p,p'-DDD, and p,p'-DDE in fish. |
| PubMed: | Effects of different anticoagulants on human platelet size distribution and serotonin (5-HT) induced shape change and uptake kinetics. |
| PubMed: | High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in Parkinsonian patients. |
| PubMed: | In vivo study of the influence of adenine and guanosine on the erythrocytes of ACD (pH 5.0 and 5.6) preserved blood. |
| PubMed: | Effects of sodium picosulfate and other laxatives in cultured Chang cells. |
| PubMed: | Zinc-iodide-osmium procedures as markers of subcellular structures. I. Standardization of staining of transmitter containing vesicles. |
| PubMed: | Aggregation of calcium oxalate crystals: effect of urine and various inhibitors. |
| PubMed: | Some properties of p-coumarate decarboxylase from Cladosporium phlei. |
| PubMed: | The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride. |
| PubMed: | Inhibition of Rh agglutination by disodium hydrogen citrate. |
| PubMed: | Disodium-Citrate-Glucose Mixture as a Blood Preservative. |
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