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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 209.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.200000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 178.00 °F. TCC ( 81.10 °C. ) (est)
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| logP (o/w): | 0.350 |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 25 °C (exp) | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Arecoline > 95%
Odor: characteristic Use: Arecoline has shown regulatory properties of controlling plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts. |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Arecoline
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
unreported-dog LDLo 5 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
intraperitoneal-mouse LD50 190 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971.
intravenous-mouse LD50 36 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: EXCITEMENT Farmakologiya i Toksikologiya Vol. 28, Pg. 33, 1965.
oral-mouse LD50 550 mg/kg European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 26, Pg. 853, 1991.
unreported-mouse LDLo 100 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
intraperitoneal-rat LD50 40 mg/kg SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
VASCULAR: CONTRACTION (ISOLATED TISSUES) Biochemical Journal. Vol. 113, Pg. 123, 1969.
oral-rat LD50 2500 mg/kg European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 26, Pg. 853, 1991.
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| Dermal Toxicity: |
subcutaneous-dog LD50 5 mg/kg Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 17, Pg. 108, 1973.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for arecoline usage levels up to: | | | not for fragrance use.
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| Recommendation for arecoline flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2230 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate |
| Chemidplus: | 0000063752 |
References:
| | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 2230 |
| Pubchem (sid): | 134971811 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arecaidine methyl ester | | | arecaline | | | arecholin | | | arecholine | | | arecolin | | | arecoline base | | | arecoline1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester | | | methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate | | | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate | | | methyl 1,2,5,6-tetrahydro-1-methyl nicotinate | | | methyl 1,2,5,6-tetrahydro-1-methylnicotinate | | | methyl arecaiden | | | methyl methyl tetrahydronicotinate | | | methyl methyl-1,2,5,6-tetrahydronicotinate | | | methyl N-methyl tetrahydronicotinate | | | methyl N-methyl-1,2,5,6-tetrahydronicotinate | | | methyl N-methyltetrahydronicotinate | | 1- | methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester | | N- | methyl-d-tetrahydronicotinic acid methyl ester | | 1- | methyl-d(sup 3,4)tetrahydro-3-pyridinecarboxylate | | 1- | methyl-delta(sup 3,4)tetrahydro-3-pyridine carboxylate | | | methylarecaiden | | | methylarecaidin | | | methylarecaidine | | N- | methyltetrahydronicotinic acid, methyl ester | | | nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester | | 3- | pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester | | 1,2,5,6- | tetrahydro-1-methyl-3-pyridine carboxylic acid methyl ester | | 1,2,5,6- | tetrahydro-1-methyl-3-pyridinecarboxylic acid methyl ester | | 1,2,5,6- | tetrahydro-1-methylnicotinic acid, methyl ester |
Articles:
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