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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 583.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 584.00 °F. TCC ( 306.60 °C. ) (est)
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| logP (o/w): | 1.090 (est) |
| Soluble in: |
| | water, 8200 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for (-)-epiafzelechin usage levels up to: | | | not for fragrance use.
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| Recommendation for (-)-epiafzelechin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 443639 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | (2R,3R)-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol |
References:
| | (2R,3R)-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 443639 |
| Pubchem (sid): | 36886878 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2R,3R)-2-(4- | hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol | | (2R,3R)-2-(4- | hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol |
Articles:
| PubMed: | Development of a UPLC-MS/MS bioanalytical method for the pharmacokinetic study of (-)-epiafzelechin, a flavan-3-ol with osteoprotective activity, in C57BL/6J mice. |
| PubMed: | Phytotoxic flavonoids from roots of Stellera chamaejasme L. (Thymelaeaceae). |
| PubMed: | Isolation and purification of condensed tannins from flamboyant tree and their antioxidant and antityrosinase activities. |
| PubMed: | Preparation and characterisation of peanut seed skin polyphenols. |
| PubMed: | Proanthocyanidins from Spenceria ramalana and their effects on AGE formation in vitro and hyaloid-retinal vessel dilation in larval zebrafish in vivo. |
| PubMed: | Promoting osteoblast differentiation by the flavanes from Huangshan Maofeng tea is linked to a reduction of oxidative stress. |
| PubMed: | [Chemical constituents of Camellia sinensis var. assamica]. |
| PubMed: | Flavan-3-ol-cysteine and acetylcysteine conjugates from edible reagents and the stems of Cynomorium songaricum as potent antioxidants. |
| PubMed: | A new flavan-3-ol dimer from Ficus spragueana leaves and its cytotoxic activity. |
| PubMed: | 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. |
| PubMed: | [A new flavanol glycoside from Phymatopteris hastata with effect on glucose metabolism]. |
| PubMed: | Antioxidant activity and proanthocyanidin profile of Selliguea feei rhizomes. |
| PubMed: | Proanthocyanidin oligomers isolated from Salacia reticulata leaves potently inhibit pancreatic lipase activity. |
| PubMed: | Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities. |
| PubMed: | Antioxidant phenolic compounds from Pu-erh tea. |
| PubMed: | Unified approach to catechin hetero-oligomers: first total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujuba. |
| PubMed: | [Flavonoids from Artocarpus hypargyreus]. |
| PubMed: | Flavan-3-ols from the rhizomes of Drynaria fortunei. |
| PubMed: | Antioxidant activity and low cytotoxicity of extracts and isolated compounds from Araucaria angustifolia dead bark. |
| PubMed: | New hopane triterpenes and antioxidant constituents from Potentilla fulgens. |
| PubMed: | Epiafzelechin from the root bark of Cassia sieberiana: detection by DART mass spectrometry, spectroscopic characterization, and antioxidant properties. |
| PubMed: | A-type proanthocyanidins from lychee seeds and their antioxidant and antiviral activities. |
| PubMed: | [Chemical constituents of Acacia catechu]. |
| PubMed: | Proanthocyanidins and a phloroglucinol derivative from Rumex acetosa L. |
| PubMed: | Muscarinic-dependent inhibition of gastric emptying and intestinal motility by fractions of Maytenus ilicifolia Mart ex. Reissek. |
| PubMed: | Separation of proanthocyanidins isolated from tea leaves using high-speed counter-current chromatography. |
| PubMed: | Flavonoids from Daphne giraldii Nitsche. |
| PubMed: | Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae). |
| PubMed: | Identification of galloylated propelargonidins and procyanidins in buckwheat grain and quantification of rutin and flavanols from homostylous hybrids originating from F. esculentumxF. homotropicum. |
| PubMed: | Redirection of flavonoid biosynthesis through the down-regulation of an anthocyanidin glucosyltransferase in ripening strawberry fruit. |
| PubMed: | HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. |
| PubMed: | Oligomeric proanthocyanidins from mangosteen pericarps. |
| PubMed: | Cytoprotective constituent of Hoveniae Lignum on both Hep G2 cells and rat primary hepatocytes. |
| PubMed: | Floral Trifolium proanthocyanidins: polyphenol formation and compositional diversity. |
| PubMed: | ent-Epiafzelechin-(4alpha-->8)-epiafzelechin extracted from Cassia javanica inhibits herpes simplex virus type 2 replication. |
| PubMed: | [Isolation and indentification of chemical compounds from Drynaria fortunei]. |
| PubMed: | Lipoxygenase inhibitory constituents from Periploca aphylla. |
| PubMed: | Dimeric anthocyanins from strawberry (Fragaria ananassa) consisting of pelargonidin 3-glucoside covalently linked to four flavan-3-ols. |
| PubMed: | Proliferative effects of flavan-3-ols and propelargonidins from rhizomes of Drynaria fortunei on MCF-7 and osteoblastic cells. |
| PubMed: | New perspectives on proanthocyanidin biochemistry and molecular regulation. |
| PubMed: | Typhaphthalide and typharin, two phenolic compounds from Typha capensis. |
| PubMed: | Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
| PubMed: | Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus. |
| PubMed: | Two A-type proanthocyanidins from Prunus armeniaca roots. |
| PubMed: | Inhibitory effects on HIV-1 protease of constituents from the wood of Xanthoceras sorbifolia. |
| PubMed: | (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. |
| PubMed: | An A-type proanthocyanidin from Prunus armeniaca. |
| PubMed: | Methylated A-type proanthocyanidins and related metabolites from Cassipourea gummiflua. |
| PubMed: | Selligueain A, a novel highly sweet proanthocyanidin from the rhizomes of Selliguea feei. |
| PubMed: | [Chemical constituents of Drynaria propinqua (Wall) J. Sm]. |
| PubMed: | Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro. |
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