Articles:
2H-pyran-2-one, tetrahydro-4-hydroxy-4-methyl-
Notes:
Mevalonolactone is a substance obtained by the dehydration of mevalonic acid and is rapidly converted back into mevalonic acid in water. Mevaolonic acid exists in equilibrium with mevalolactone, which is formed by internal condensation of mevalonic acid's terminal alcohol and carboxylic acid functional groups. Mevalonic acid is a key intermediate in the biosynthesis of terpenes and steroids. Mevalonolactone is known ot inhibit HMG-CoA reductase activity. [HMDB]
| CAS Number: | 674-26-0 |  3D/inchi
|
| Other(deleted CASRN): | 503-48-0 | |
| ECHA EINECS - REACH Pre-Reg: | 211-615-0 | |
| FDA UNII: | 1RJ06DC41B | |
| Nikkaji Web: | J38.600F | |
| Beilstein Number: | 080960 | |
| MDL: | MFCD00006648 | |
| XlogP3: | -0.30 (est) | |
| Molecular Weight: | 130.14330000 | |
| Formula: | C6 H10 O3 | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. ) |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
humectants |
Suppliers:
| Carbosynth |
| For experimental / research use only. |
| D,L-Mevalonic acid lactone |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| DL-Mevalonolactone |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| (±)-Mevalonolactone ∼97% (titration) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for mevalonolactone usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for mevalonolactone flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 10428 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 4-hydroxy-4-methyloxan-2-one | |
| Chemidplus: | 0000674260 |
References:
| 4-hydroxy-4-methyloxan-2-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10428 |
| Pubchem (sid): | 135052786 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| Golm Metabolome Database: | Search |
| HMDB (The Human Metabolome Database): | HMDB06024 |
| FooDB: | FDB023804 |
| Export Tariff Code: | 2932.29.5050 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| 4- | hydroxy-4-methyloxan-2-one |
| mevalonic acid lactone | |
| DL- | mevalonic acid lactone |
| mevalonolactone, (+/-)- | |
| 2H- | pyran-2-one, tetrahydro-4-hydroxy-4-methyl- |
| tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one | |
| (1)- | tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one |