sciadopitysin
amentoflavone-4',4''',7''-trimethylether
 
Notes:
biflavonoid from taxus celebica & ginkgo biloba.
  • BOC Sciences
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      Product(s):
      521-34-6 Sciadopitysin 0.98
      Sciadopitysin comes from the leaves of Ginkgo biloba L. Sciadopitysin may prevent the development of diabetic osteopathy and exert its therapeutic effects via upregulation of mitochondrial biogenesis anti-Alzheimer's disease
       
       
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CAS Number: 521-34-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 208-311-5
FDA UNII: WL44VY201L
Nikkaji Web: J92.489J
MDL: MFCD00017448
XlogP3-AA: 6.00 (est)
Molecular Weight: 580.54628000
Formula: C33 H24 O10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 839.60 °C. @ 760.00 mm Hg (est)
Flash Point: 529.00 °F. TCC ( 276.20 °C. ) (est)
logP (o/w): 5.500 (est)
Soluble in:
 water, 0.0006502 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Sciadopitysin 0.98
Odor: characteristic
Use: Sciadopitysin comes from the leaves of Ginkgo biloba L. Sciadopitysin may prevent the development of diabetic osteopathy and exert its therapeutic effects via upregulation of mitochondrial biogenesis anti-Alzheimer's disease
Carbosynth
For experimental / research use only.
Sciadopitysin
Coompo
For experimental / research use only.
Sciadopitysin from Plants ≥98%
ExtraSynthese
For experimental / research use only.
Sciadopitysin (HPLC) ≥99%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for sciadopitysin usage levels up to:
 not for fragrance use.
 
Recommendation for sciadopitysin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5281696
National Institute of Allergy and Infectious Diseases: Data
 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
Chemidplus: 0000521346
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References:
 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5281696
Pubchem (sid): 135030274
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10182
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 amentoflavone-4',4''',7''-trimethylether
 amentoflavone-4',4",7-trimethyl ether
 amentoflavone-7,4',4'''-trimethyl ether
5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1- benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4- benzopyrone
5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one
5,7-dihydroxy-8-[5-(5-hydroxy-7-méthoxy-4-oxo-4H-chromén-2-yl)-2-méthoxyphényl]-2-(4-méthoxyphényl)-4H-chromén-4-one
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
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Articles:
PubMed: Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.
PubMed: Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.
PubMed: Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells.
PubMed: Two new nonacosanetriols from Ginkgo biloba sarcotesta.
PubMed: [Structrue identification of biflavones and determination of Taxol from Taxus Madia].
PubMed: [Non-taxoid chemical constituents from leaves of Taxus mairei].
PubMed: New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes.
PubMed: In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.
PubMed: Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).
PubMed: Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana.
PubMed: Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba.
PubMed: Biflavones from Chamaecyparis obtusa.
PubMed: Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.
PubMed: Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba.
PubMed: Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
PubMed: Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro.
PubMed: Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
PubMed: [HPLC determination of six flavonoid constituents in Ginkgo biloba leaves].
PubMed: Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast.
PubMed: Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids.
PubMed: Flavonoid-induced acute nephropathy.
PubMed: Inhibition of human non-pancreatic phospholipases A2 by retinoids and flavonoids. Mechanism of action.
PubMed: Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase.
PubMed: HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba.
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