Articles:
| None found yet. Try the PubMed Search. |
7-chloro-6-demethyltetracycline hydrochloride
Notes:
a tetracycline analog having a 7-chloro and a 6-methyl. because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 64-73-3 Demeclocycline hydrochloride >98% Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.
-
-
Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GA7186 Demeclocycline hydrochloride
-
| CAS Number: | 64-73-3 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-592-2 | |
| FDA UNII: | 29O079NTYT | |
| MDL: | MFCD00082371 | |
| Molecular Weight: | 501.31794000 | |
| Formula: | C21 H22 Cl2 N2 O8 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 684.50 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 815.00 °F. TCC ( 435.20 °C. ) (est) |
| Soluble in: | |
| water, 8.493e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Demeclocycline hydrochloride >98%
Odor: characteristic Use: Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections. |
| George Uhe Company |
| Demeclocycline HCL |
| Glentham Life Sciences |
| Demeclocycline hydrochloride |
| Matrix Scientific |
| For experimental / research use only. |
| Demeclocycline hydrochloride, 95+% |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Demeclocycline Hydrochloride ≥93% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Demeclocycline hydrochloride ≥90% (HPLC), powder |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-man TDLo 69 mg/kg/4D-I KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION American Journal of Kidney Diseases. Vol. 5, Pg. 270, 1985. intravenous-mouse LD50 275 mg/kg Archivio Italiano di Scienze Mediche Tropical e di Parassitologia. Italian Archives of the Science of Tropical Medicine and Parasitology. Vol. 43, Pg. 143, 1962. oral-mouse LD50 2150 mg/kg Drugs in Japan Vol. -, Pg. 704, 1990. intravenous-rat LD50 94 mg/kg Drugs in Japan Vol. -, Pg. 704, 1990. oral-rat LD50 2372 mg/kg Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for demeclocycline hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for demeclocycline hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 54686764 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | |
| Chemidplus: | 0000064733 |
References:
| (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 54686764 |
| Pubchem (sid): | 135017847 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D00290 |
| HMDB (The Human Metabolome Database): | Search |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 7- | chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride |
| (4S,4aS,5aS,6S,12aR)-7- | chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride |
| 7- | chloro-6-demethyltetracycline hydrochloride |
| declomycin hydrochloride | |
| demethylchlorotetracycline hydrochloride | |
| ledermycin hydrochloride |