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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | orange-yellow solid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Carmustine >98%
Odor: characteristic Use: Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Carmustine ≥98%
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-child LDLo 78 mg/kg/52W-I LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE Cancer Vol. 42, Pg. 74, 1978.
intravenous-dog LDLo 2 mg/kg Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 33, 1973.
oral-dog LDLo 5 mg/kg Advances in Cancer Research. Vol. 16, Pg. 273, 1972.
parenteral-hamster LD10 18 mg/kg Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980.
intravenous-human TDLo 6 mg/kg BLOOD: THROMBOCYTOPENIA
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: LEUKOPENIA Cancer Treatment Reports. Vol. 60, Pg. 709, 1976.
intravenous-human TDLo 125 mg/kg BLOOD: LEUKOPENIA
BLOOD: THROMBOCYTOPENIA
GASTROINTESTINAL: NAUSEA OR VOMITING Advances in Cancer Research. Vol. 16, Pg. 273, 1972.
intramuscular-mouse LD50 86300 ug/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 766, 1978.
intraperitoneal-mouse LD50 21260 ug/kg National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986
intravenous-mouse LD50 45 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 118, Pg. 756, 1965.
oral-mouse LD50 19 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972.
unreported-mouse LD50 42 mg/kg Cancer Research. Vol. 46, Pg. 2703, 1986.
intramuscular-rat LD50 79600 ug/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 766, 1978.
intraperitoneal-rat LD50 17420 ug/kg National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986
intravenous-rat LD50 13800 ug/kg LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE Oncology. Vol. 37, Pg. 177, 1980.
oral-rat LD50 20 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 166, Pg. 104, 1969.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 24 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972.
subcutaneous-rat LD50 83200 ug/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ATAXIA Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 766, 1978.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for carmustine usage levels up to: | | | not for fragrance use.
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| Recommendation for carmustine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | BCNU | | | carmubris | | bis | chloroethyl nitrosourea | | 1,3-bis(2- | chloroethyl)-1-nitrosourea | | N,N'-bis(2- | chloroethyl)-N-nitrosourea | | bis-N,N'-( | chloroethyl)nitrosourea |
Articles:
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