poloxamine 908
methyl oxirane polymer with oxirane/ether with (1,2-ethane diyl dinitrilo)tetrakis(propanol)(2;122)
 
Notes:
series of surface-active block polymers with added hydrophilic (polyoxyethylene) and hydrophobic (polyoxypropylene) side chains to ethylene-diamine; used as a drug carrier.series of surface-active block polymers with added hydrophilic (polyoxyethylene) and hydrophobic (polyoxypropylene) side chains to ethylene-diamine; used as a drug carrier.
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CAS Number: 11111-34-5 
Other: 11111-35-6
Formula: C14 H32 N2 O4.4(C3 H6 O.C2 H4 O)x-
Category: emulsifiers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: emulsifying agents
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers
Recommendation for poloxamine 908 usage levels up to:
 not for fragrance use.
 
Recommendation for poloxamine 908 flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 11111-34-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0011111345
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References:
Canada Domestic Sub. List: 11111-34-5
Pubchem (sid): 135358173
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Other Information:
HMDB (The Human Metabolome Database): Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 methyl oxirane polymer with oxirane/ether with (1,2-ethane diyl dinitrilo)tetrakis(propanol)(2;122)
 oxirane, methyl-, polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis (propanol) (22;122)
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Articles:
PubMed: Detection of hepatocellular carcinoma in transgenic mice by Gd-DTPA- and rhodamine 123-conjugated human serum albumin nanoparticles in T1 magnetic resonance imaging.
PubMed: Cancer nanomedicine and the complement system activation paradigm: anaphylaxis and tumour growth.
PubMed: Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering.
PubMed: Modification of the Stewart biphasic colorimetric assay for stable and accurate quantitative determination of Pluronic and Tetronic block copolymers for application in biological systems.
PubMed: Cytotoxicity of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles in rat glioma cell lines using different assays.
PubMed: Concentration dependent structural ordering of poloxamine 908 on polystyrene nanoparticles and their modulatory role on complement consumption.
PubMed: [Development and estimation of nanosomal rifampicin].
PubMed: Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model polystyrene nanoparticles assessed by isothermal titration microcalorimetry correspond to the biological differences.
PubMed: A topical w/o/w multiple emulsions prepared with Tetronic 908 as a hydrophilic surfactant: formulation, characterization and release study.
PubMed: Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting.
PubMed: Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN).
PubMed: Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages-impact of phagocytosis on viability and cytokine production.
PubMed: Real-time evidence of surface modification at polystyrene lattices by poloxamine 908 in the presence of serum: in vivo conversion of macrophage-prone nanoparticles to stealth entities by poloxamine 908.
PubMed: Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat.
PubMed: Influence of surface-modifying surfactants on the pharmacokinetic behavior of 14C-poly (methylmethacrylate) nanoparticles in experimental tumor models.
PubMed: Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.
PubMed: Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity. Implications in experimental and clinical oncology.
PubMed: Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages.
PubMed: Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.
PubMed: Re-establishing the long circulatory behaviour of poloxamine-coated particles after repeated intravenous administration: applications in cancer drug delivery and imaging.
PubMed: Influence of the surfactant concentration on the body distribution of nanoparticles.
PubMed: Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS.
PubMed: Physical stability of ethyl diatrizoate nanocrystalline suspension in steam sterilization.
PubMed: Cloud point of nonionic surfactants: modulation with pharmaceutical excipients.
PubMed: In vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres.
PubMed: Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres.
PubMed: Activation of the mononuclear phagocyte system by poloxamine 908: its implications for targeted drug delivery.
PubMed: A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats.
PubMed: Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer.
PubMed: Prolonging the circulation time and modifying the body distribution of intravenously injected polystyrene nanospheres by prior intravenous administration of poloxamine-908. A 'hepatic-blockade' event or manipulation of nanosphere surface in vivo?
PubMed: Human serum albumin as a probe for surface conditioning--a study of the ageing effect.
PubMed: Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide).
PubMed: Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407.
PubMed: Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution.
PubMed: Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosan-stimulated rats.
PubMed: Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum.
PubMed: An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen.
PubMed: Effect of splenic congestion associated with haemolytic anaemia on filtration of 'spleen-homing' microspheres.
PubMed: Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake.
PubMed: Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles.
PubMed: The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.
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