poloxamine 701
methyl oxirane polymer with oxirane/ether with (1,2-ethane diyl dinitrilo)tetrakis(propanol)(12;2)
 
Notes:
series of surface-active block polymers with added hydrophilic (polyoxyethylene) and hydrophobic (polyoxypropylene) side chains to ethylene-diamine; used as a drug carrier.
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CAS Number: 11111-34-5 
Other: 11111-35-6
Formula: C14 H32 N2 O4.4(C3 H6 O.C2 H4 O)x-
Category: emulsifiers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: emulsifying agents
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers
Recommendation for poloxamine 701 usage levels up to:
 not for fragrance use.
 
Recommendation for poloxamine 701 flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 11111-34-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0011111345
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References:
Canada Domestic Sub. List: 11111-34-5
Pubchem (sid): 135358173
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Other Information:
HMDB (The Human Metabolome Database): Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 methyl oxirane polymer with oxirane/ether with (1,2-ethane diyl dinitrilo)tetrakis(propanol)(12;2)
 oxirane, methyl-, polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis (propanol) (12;2)
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Articles:
PubMed: Poloxamine-cyclodextrin-simvastatin supramolecular systems promote osteoblast differentiation of mesenchymal stem cells.
PubMed: Poloxamines for deswelling of organ-cultured corneas.
PubMed: Osteogenic efficiency of in situ gelling poloxamine systems with and without bone morphogenetic protein-2.
PubMed: Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering.
PubMed: Poloxamine-based nanomaterials for drug delivery.
PubMed: Moisture-activated rheological structuring of nonaqueous poloxamine-poly(acrylic acid) systems designed as novel biomedical implants.
PubMed: Concentration dependent structural ordering of poloxamine 908 on polystyrene nanoparticles and their modulatory role on complement consumption.
PubMed: Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN).
PubMed: Real-time evidence of surface modification at polystyrene lattices by poloxamine 908 in the presence of serum: in vivo conversion of macrophage-prone nanoparticles to stealth entities by poloxamine 908.
PubMed: Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity. Implications in experimental and clinical oncology.
PubMed: Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation.
PubMed: Re-establishing the long circulatory behaviour of poloxamine-coated particles after repeated intravenous administration: applications in cancer drug delivery and imaging.
PubMed: Influence of the surfactant concentration on the body distribution of nanoparticles.
PubMed: Physical stability of ethyl diatrizoate nanocrystalline suspension in steam sterilization.
PubMed: Cloud point of nonionic surfactants: modulation with pharmaceutical excipients.
PubMed: Humoral-mediated recognition of 'phagocyte-resistant' beads by lymph node macrophages of poloxamine-treated rats.
PubMed: Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres.
PubMed: Activation of the mononuclear phagocyte system by poloxamine 908: its implications for targeted drug delivery.
PubMed: A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats.
PubMed: Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer.
PubMed: Prolonging the circulation time and modifying the body distribution of intravenously injected polystyrene nanospheres by prior intravenous administration of poloxamine-908. A 'hepatic-blockade' event or manipulation of nanosphere surface in vivo?
PubMed: Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407.
PubMed: Thermally gelling poloxamine Synperonic T908 solution as a vehicle for rectal drug delivery.
PubMed: Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution.
PubMed: Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosan-stimulated rats.
PubMed: Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum.
PubMed: An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen.
PubMed: Effect of splenic congestion associated with haemolytic anaemia on filtration of 'spleen-homing' microspheres.
PubMed: The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.
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