piroctone olamine
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
 
Notes:
2(1h)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis.
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      Product(s):
      68890-66-4 Piroctone olamine 95%
       
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Product(s):
      MP-013791 PIROCTONE OLAMINE
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      HLC-1102 Piroctone Olamine
       
  • TCI AMERICA
    • TCI AMERICA
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      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      P2178 Piroctone Olamine >97.0%(HPLC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 68890-66-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 272-574-2
FDA UNII: A4V5C6R9FB
MDL: MFCD01690792
Molecular Weight: 298.42670000
Formula: C16 H30 N2 O3
NMR Predictor: Predict (works with chrome or firefox)
Category: preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 344.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000004 mmHg @ 25.00 °C. (est)
Flash Point: 323.00 °F. TCC ( 161.90 °C. ) (est)
logP (o/w): 3.696 (est)
Soluble in:
 water, 18.75 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: preservatives
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Suppliers:
BOC Sciences
For experimental / research use only.
Piroctone olamine 95%
ECSA Chemicals
PIROCTONE OLAMINE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Jiangyin Healthway
Piroctone Olamine
New functional food ingredients
Kingyoung Bio Technical
Piroctone
M.C.Biotec
Piroctone Olamine
Sigma-Aldrich
For experimental / research use only.
Piroctone Olamine
analytical standard
Spec-Chem Industry
SpecKare TM PO(Pirotone Olamine)
TCI AMERICA
For experimental / research use only.
Piroctone Olamine >97.0%(HPLC)(T)
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  5000 mg/kg
Farmaco. Vol. 53, Pg. 405, 1998.

oral-rat LD50  8100 mg/kg
Farmaco. Vol. 53, Pg. 405, 1998.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: preservatives
Recommendation for piroctone olamine usage levels up to:
 not for fragrance use.
 
Recommendation for piroctone olamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 50258
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 2
 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
Chemidplus: 0068890664
RTECS: UU7786150 for cas# 68890-66-4
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References:
 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 50258
Pubchem (sid): 135008949
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): D05505
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.79.1500
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 preservatives 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
 octopirox
 piroctone ethanolamine salt
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)
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Articles:
PubMed: Effect of Wnt inhibitors in pancreatic cancer.
PubMed: Targeting the Wnt/beta-catenin pathway in renal cell carcinoma.
PubMed: Preparation and evaluation of the effect of Fe3 O4 @piroctone olamine magnetic nanoparticles on matrix metalloproteinase-2: a preliminary in vitro study.
PubMed: Targeting renal cancer with a combination of WNT inhibitors and a bi-functional peptide.
PubMed: Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus.
PubMed: Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure.
PubMed: Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.
PubMed: Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.
PubMed: Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
PubMed: The in vitro effect of a collagenolytic enzyme inhibitor on lesion development in root dentin.
PubMed: The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo.
PubMed: Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
PubMed: Effect of residence time on the efficacy of antidandruff shampoos.
PubMed: Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial.
PubMed: In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans.
PubMed: [Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
PubMed: In vitro antimycotic activity and nail permeation models of a piroctone olamine (octopirox) containing transungual water soluble technology.
PubMed: Enhanced delivery of an anti-dandruff active in a shampoo vehicle.
PubMed: Comparative anti-dandruff efficacy between a tar and a non-tar shampoo.
PubMed: [Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].
PubMed: Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders.
PubMed: In vitro susceptibility of Malassezia furfur.
PubMed: Evaluation de l'activité antifongique de deux dérivés et test d'innocuitéin vivo de shampooings à visée antipelliculaire ainsi formulés.
PubMed: The effect of piroctone olamine on reproduction of male and female rats.
PubMed: The effects of dietary iron supplementation on the toxicity of piroctone olamine in the growing rat.
PubMed: Percutaneous absorption of Octopirox.
PubMed: [Anti-pityriasis activity of a line of products containing piroctone olamine].
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