chlorphenesin
p-chlorophenyl a-glyceryl ether
 
Notes:
a centrally acting muscle relaxant. its mode of action is unknown. (from martindale, the extra pharmacopoeia, 30th ed, p1203)
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it.
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      CLPLIC Chlorphenesin
       
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      104-29-0 3-(4-Chlorophenoxy)-1,2-propanediol 98%
       
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      MP-017781 CHLORPHENESIN
       
  • Indukern F&F
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      Product(s):
      HLC-612 Chlorphenesin
       
Synonyms   Articles   Notes   Search
CAS Number: 104-29-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-192-6
FDA UNII: I670DAL4SZ
Nikkaji Web: J5.029F
Beilstein Number: 2210845
XlogP3-AA: 1.20 (est)
Molecular Weight: 202.63627000
Formula: C9 H11 Cl O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 78.00 °C. @ 760.00 mm Hg
Boiling Point: 369.45 °C. @ 760.00 mm Hg (est)
Flash Point: 351.00 °F. TCC ( 177.20 °C. ) (est)
logP (o/w): 1.713 (est)
Soluble in:
 water, 2204 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
preservatives
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Suppliers:
American International Chemical, LLC.
Chlorphenesin
BOC Sciences
For experimental / research use only.
3-(4-Chlorophenoxy)-1,2-propanediol 98%
Connect Chemicals
Chlorphenesin
Odor: characteristic
Use: Chlorphenesin (CHP) is a wide spectrum hydrosoluble antimicrobial substance, active against bacteria, fungi and yeasts. It is used as a polyvalent preservative for microbiological protection of cosmetic products. CHP is suitable for microbiological stabilization of cosmetics, including emulsions (creams, lotions), masks, gels, aqueous or alcoholic solutes, sprays, sticks, serums, tonics, makeup products (eyeliner, mascaras...), shampoos, conditioners, foams.
ECSA Chemicals
CHLORPHENESIN
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CHLORPHENESIN
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Chlorphenesin
New functional food ingredients
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-mouse LD50 911 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 470, 1948.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial preservatives
Recommendation for chlorphenesin usage levels up to:
 not for fragrance use.
 
Recommendation for chlorphenesin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7697
National Institute of Allergy and Infectious Diseases: Data
 3-(4-chlorophenoxy)propane-1,2-diol
Chemidplus: 0000104290
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References:
 3-(4-chlorophenoxy)propane-1,2-diol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 7697
Pubchem (sid): 134972726
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C07928
HMDB (The Human Metabolome Database): HMDB14994
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 preservatives 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
 adermykon
 chlorophenesin
3-(4-chlorophenoxy)-1,2-propanediol
3-(p-chlorophenoxy)-1,2-propanediol
3-(4-chlorophenoxy)propane-1,2-diol
3-(p-chlorophenoxy)propane-1,2-diol
p-chlorophenyl a-glyceryl ether
p-chlorophenyl-a-glyceryl ether
2-chlorphenesin
 chlorphenesine
 chlorphenesinum
 demykon
 gechophen
 gecophen
 mycil
1,2-propanediol, 3- (p-chlorophenoxy)-
1,2-propanediol, 3-(4-chlorophenoxy)-
1,2-propanediol, 3-(p-chlorophenoxy)-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: [Analysis of the preservative chlorphenesin in cosmetics by high performance liquid chromatography].
PubMed: Contact allergy to chlorphenesin.
PubMed: Occurrence of preservatives and antimicrobials in Japanese rivers.
PubMed: Production of chlorphenesin galactoside by whole cells of β-galactosidase-containing Escherichia coli.
PubMed: β-galactosidase-catalyzed synthesis of galactosyl chlorphenesin and its characterization.
PubMed: Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea.
PubMed: High-throughput and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry in the positive and negative ionization modes.
PubMed: Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial.
PubMed: [Detection of the preservative chlorphenesin in cosmetics by high-performance liquid chromatography].
PubMed: Comparison of objective and sensory skin irritations of several cosmetic preservatives.
PubMed: The synthesis of amphipathic prodrugs of 1,2-diol drugs with saccharide conjugates by high regioselective enzymatic protocol.
PubMed: HPLC determination of tolperisone in human plasma.
PubMed: Beta-galactosidase catalyzed selective galactosylation of aromatic compounds.
PubMed: Optimization of chlorphenesin emulgel formulation.
PubMed: Two cases of facial dermatitis due to chlorphenesin in cosmetics.
PubMed: Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.
PubMed: [Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)].
PubMed: Dermatitis from chlorphenesin in a facial cosmetic.
PubMed: [The photostability of antimycotics. 3. Photostability of locally acting antimycotics].
PubMed: Indirect spectrophotometric methods for the determination of chlorphenesin.
PubMed: Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner.
PubMed: Trigeminal neuralgia.
PubMed: Medical treatment of the major neuralgias.
PubMed: Simultaneous evaluation of drug effects on both the spinal cord and the descending pathways in rats.
PubMed: Dermatitis from chlorphenesin in a deodorant.
PubMed: Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats.
PubMed: Studies on the kinetics and mechanism of drug degradation. I. Kinetics and mechanism of degradation of chlorphenesin carbamate in strongly alkaline aqueous solutions.
PubMed: Allergic contact sensitivity to chlorphenesin.
PubMed: [Treatment of typical trigeminus neuralgias. Overview of the current state of drug and surgical therapy].
PubMed: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.
PubMed: Cluster headache with trigeminal neuralgia. An uncommon association that may be more than coincidental.
PubMed: [Vaginal mycosis. Therapy with chlorphenesin].
PubMed: An experimental study of the F-wave in the dog: effects of spasticity and central muscle relaxant.
PubMed: Trigeminal neuralgia. A practical approach to treatment.
PubMed: Fixed drug eruption from chlorphenesin carbamate.
PubMed: Chlorphenesin sensitivity.
PubMed: Tic douloureux.
PubMed: Centrally acting oral skeletal muscle relaxants.
PubMed: The action of chlorphenesin carbamate on the frog spinal cord.
PubMed: Suppressive effects of chlorphenesin on lymphocyte function in mice and humans.
PubMed: [Mycological and clinical studies on a new local antimycotic drug].
PubMed: [Influence of the enterohepatic circulation on the metabolism of chlorphenesin carbamate (CPC). II. Metabolic fate of biliary CPC-glucuronide (author's transl)].
PubMed: [Influence of the enterohepatic circulation on the metabolism of chlorphenesin carbamate (CPC). I. Comparison between guinea pigs and bile duct-ligated rats (author's transl)].
PubMed: [Electroencephalographic effects of chlorphenesin carbamate, a new central muscle relaxant, in rabbits (author's transl)].
PubMed: [Studies on the physical dependence liability of chlorphenesin carbamate (author's transl)].
PubMed: The management of tic douloureux.
PubMed: [A pharmacological study of chlorphenesin carbamate. Tolerance to chlorphenesin carbamate (author's transl)].
PubMed: Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents.
PubMed: Medical treatment of trigeminal neuralgia.
PubMed: High-pressure liquid chromatographic determination of chlorphenesin carbamate and the beta-isomeric carbamate.
PubMed: Interactions of chlorphenesin and divalent metal ions with phosphodiesterase.
PubMed: New non-steroid non-antibiotic skin medicaments.
PubMed: Initiation-promotion skin carcinogenesis and immunological competence.
PubMed: [Muscle relaxants in the treatment of idiopathic trigeminal neuralgia (author's transl)].
PubMed: Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs.
PubMed: Chlorphenesin carbamate serum levels during subchronic administration to human (normal) volunteers.
PubMed: Field desorption mass spectrometry of ten medicinal carbamates.
PubMed: GLC determination of chlorphenesin carbamate in serum.
PubMed: Basophil activation by concanavalin A: characteristics of the reaction.
PubMed: [Pharmacologial studies on a centrally acting muscle relaxant, chlorphenesin carbamate, with special reference to the effect on the motor system].
PubMed: Soluble lymphocytic mediators. I. Inhibition of macrophage migration inhibitory factor production by drugs.
PubMed: Chlorphenesin for trigeminal neuralgia.
PubMed: Influence of genotype of host on regression of solid and ascitic forms of sarcoma 180 and effect of chemotherapy on the solid form.
PubMed: [Progress in the treatment of bronchial asthma].
PubMed: The immunologic effect of chlorphenesin on skin grafts in normal and thymectomized mice.
PubMed: Synthesis and pharmacological activity of some chlorphenesin phenoxyalkanoates.
PubMed: Attenuation of certain neoplasias by chlorphenesin. 1.
PubMed: Cyclic AMP affects macrophage migration.
PubMed: Normal neonatal mandibular growth not affected by muscular inactivity.
PubMed: Comparative pharmacokinetics of chlorphenesin carbamate and methocarbamol in man.
PubMed: The immediate allergic response: in vitro separation of antigen activation, decay and histamine release.
PubMed: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin.
PubMed: Drug-induced modulation of the immunologic release of histamine and slow reacting substance of anaphylaxis.
PubMed: Chlorphenesin: an antigen-associated immunosuppressant.
PubMed: Interaction between "sensitized lymphocytes" and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors.
PubMed: Therapeutics X. Topical antifungal agents.
PubMed: Gas chromatographic determination of chlorphenesin in plasma.
PubMed: Shear cell measurements of powders: proposed procedures for elucidating the mechanistic behavior of powder beds in shear.
PubMed: A comparative trial of chlorphenesin and pecilocin in a prison community.
PubMed: Chlorphenesin metabolism in the rat and dog.
PubMed: Chlorphenesin: a new inhibitor IgE-mediated histamine release.
PubMed: Chlorphenesin: a new inhibitor of IgE-mediated histamine release.
PubMed: The influence of chlorphenesin carbamate and carisoprodol on psychological test scores.
PubMed: Renal distrubution of sulfisoxazole in canine kidney.
PubMed: A comparison between propoxyphene hydrochloride (Darvon) and chlorphenesin carbamate (Maolate) in musculoskeletal disorders. A controlled study in 92 patients.
PubMed: The effect of chlorphenesin on the immune response.
PubMed: [Treatment of trigeminal neuralgia with muscle relaxants].
PubMed: Effect of chlorphenesin on localized hemolysis in gel assay.
PubMed: Still more corticosteroid preparations for the skin. Synalar Forte, Fluoderm, Ultralanum Cream.
PubMed: The analgesic properties of chlorphenesin carbamate in the treatment of osteoarthrosis. Report of a trial.
PubMed: [Hydrocortisone therapy in outpatient care].
PubMed: Comparative analgesic efficacy of chlorphenesin carbamate and acetylsalicylic acid after episiotomy.
PubMed: Maolate (chlorphenesin carbamate) a new myanalgic drug in industrial medicine.
PubMed: Chlorphenesin carbamate (Maolate).
PubMed: Metabolism of 3-(p-chlorophenoxy)-2-methoxypropyl carbamate in the rat.
PubMed: Qualitative and quantitative tests for chlorphenesin carbamate.
PubMed: Chlorphenesin carbamate in the treatment of muscle spasm and musculoskeletal disorders.
PubMed: Chlorphenesin carbamate (maolate) in the relief of muscle pain.
PubMed: Preparation of tritium-labeled compounds. II. Chlorphenesin carbamate by exposure to tritium gas and determination of intramolecular distribution of tritium.
PubMed: Selective suppression of penicillin hypersensitivity by certain phenoxy propanediols.
PubMed: The absorption, excretion, and metabolism of chlorphenesin carbamate in the dog.
PubMed: Clinical evaluation of chlorphenesin carbamate (maolate) in spasticity, rigidity and pain associated with neurologic and arthritic diseases.
PubMed: CHARACTERIZATION OF THE GLUCURONIDE CONJUGATE OF CHLORPHENESIN CARBAMATE FROM THE RAT AND FROM MAN.
PubMed: DETERMINATION OF RESIDUAL CHLORPHENESIN IN CHLORPHENESIN-1-CARBAMATE.
PubMed: THE METABOLISM OF CHLORPHENESIN CARBAMATE.
PubMed: A CONTROLLED EVALUATION OF CHLORPHENESIN CARBAMATE IN PAINFUL MUSCULOSKELETAL SYNDROMES.
PubMed: EFFECT OF CHLORPHENESIN CARBAMATE (MAOLATE) ON A CASE OF ACUTE ARACHNIDISM.
PubMed: CLINICAL TRIAL OF CHLORPHENESIN CARBAMATE IN PATIENTS WITH MUSCLE SPASM.
PubMed: Controlled clinical evaluation of a new muscle relaxant--chlorphenesin carbamate.
PubMed: Controlled clinical evaluation of a new muscle relaxant-chlorphenesin carbamate.
PubMed: The pharmacology of chlorphenesin carbamate, a centrally active muscle relaxant.
PubMed: Clinical evaluation of the analgesic activity of chlorphenesin carbamate.
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