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Category: nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder or liquid (est) |
| Assay: | 55.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 5.664e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 10000 mg/kg "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 98, 1972.
intravenous-rat LD50 3410 mg/kg "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 98, 1972.
intraperitoneal-rat LD50 4810 mg/kg "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 98, 1972.
oral-mouse LD50 > 10000 mg/kg Drugs in Japan Vol. 6, Pg. 598, 1982.
intravenous-mouse LD50 3400 mg/kg Drugs in Japan Vol. 6, Pg. 598, 1982.
intraperitoneal-mouse LD50 4800 mg/kg Drugs in Japan Vol. 6, Pg. 598, 1982.
|
| Dermal Toxicity: |
subcutaneous-rat LD50 > 4870 mg/kg "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 98, 1972.
subcutaneous-mouse LD50 4870 mg/kg Drugs in Japan Vol. 6, Pg. 598, 1982.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | nutrient supplements |
| Recommendation for pantethine usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for pantethine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Pantethine as source for pantothenic acid added as a nutritional substance in food supplements - Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food (ANS) View page or View pdf |
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 452306 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide |
| Chemidplus: | 0016816674 |
| RTECS: | ES4392700 for cas# 16816-67-4 |
References:
| | (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 452306 |
| Pubchem (sid): | 134993304 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)- | | | butyramide, N,N'-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,3-dimethyl-, D-(+)- | | | butyramide, N,N'-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,3-dimethyl-,D-(+)- | | (2R)-N-[3-[2-[2-[3-[[(2R)-2,4- | dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide | | (2R,2'R)-N,N'-{ | disulfanediylbis[ethane-2,1-diylimino(3-oxopropane-3,1-diyl)]}bis(2,4-dihydroxy-3,3-dimethylbutanamide) | | (R-(R*,R*))-N,N'-( | dithiobis(ethyleneimino(3-oxopropane-3,1-diyl))) bis(2,4-dihydroxy-3,3-dimethyl butyramide) | | (r-(R*,R*))-N,N'-( | dithiobis(ethyleneimino(3-oxopropane-3,1-diyl)))bis(2,4-dihydroxy-3,3-dimethylbutyramide) | | | lipodel | | D- | pantethine | | | pantetina | | | pantosin | | bis( | pantothenamidoethyl) disulfide | | D-bis(N- | pantothenyl-2-aminoethyl)-disulfide | | D-bis(N- | pantothenyl-beta-aminoethyl) disulfide | | bis(N- | pantothenylamidoethyl) disulfide |
Articles:
| PubMed: | Pantethine prevents murine systemic sclerosis in the mouse through the inhibition of microparticle shedding. |
| PubMed: | Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration. |
| PubMed: | Targeting Microparticle Biogenesis: A Novel Approach to the Circumvention of Cancer Multidrug Resistance. |
| PubMed: | [Deceleration of cataract development in rats under the action of N-acetylcarnosine and D-pantethine mixture]. |
| PubMed: | The STM4195 Gene Product (PanS) Transports Coenzyme A Precursors in Salmonella enterica. |
| PubMed: | Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study. |
| PubMed: | Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study. |
| PubMed: | Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. |
| PubMed: | The synthesis of minds and molecules leads to potential therapy for pantothenate kinase-associated neurodegeneration. |
| PubMed: | Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model. |
| PubMed: | Integrated electroosmotic perfusion of tissue with online microfluidic analysis to track the metabolism of cystamine, pantethine, and coenzyme A. |
| PubMed: | D-pantethine has vitamin activity equivalent to d-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats. |
| PubMed: | Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. |
| PubMed: | Self-assembly of protein aggregates in ageing disorders: the lens and cataract model. |
| PubMed: | Nutraceutical strategies for ameliorating the toxic effects of alcohol. |
| PubMed: | Pantothenate kinase-associated neurodegeneration. |
| PubMed: | The role of nutraceutical supplements in the treatment of dyslipidemia. |
| PubMed: | Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. |
| PubMed: | Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers. |
| PubMed: | Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. |
| PubMed: | Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa. |
| PubMed: | Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats. |
| PubMed: | Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase. |
| PubMed: | Pantethine. Monograph. |
| PubMed: | New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans. |
| PubMed: | Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury. |
| PubMed: | Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration. |
| PubMed: | Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. |
| PubMed: | Pharmaceutical interventions facilitate premedication and prevent opioid-induced constipation and emesis in cancer patients. |
| PubMed: | Current medical aspects of pantethine. |
| PubMed: | Topical apolipoprotein A-1 may have a beneficial effect on the corneal epithelium in a mouse model of dry eye: a pilot study. |
| PubMed: | Protection against cerebral malaria by the low-molecular-weight thiol pantethine. |
| PubMed: | Combined pantethine and probucol therapy for Japanese patients with non-alcoholic steatohepatitis. |
| PubMed: | Cysteamine-related agents could be potential antidepressants through increasing central BDNF levels. |
| PubMed: | Dietary and nutraceutical options for managing the hypertriglyceridemic patient. |
| PubMed: | An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. |
| PubMed: | Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. |
| PubMed: | Hepatothermic therapy of obesity: rationale and an inventory of resources. |
| PubMed: | Can drugs or micronutrients prevent cataract? |
| PubMed: | The effects of pantethine on fatty liver and fat distribution. |
| PubMed: | Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantethine. |
| PubMed: | Natural therapies for ocular disorders, part two: cataracts and glaucoma. |
| PubMed: | The effect of pantethine and ultraviolet-B radiation on the development of lenticular opacity in the emory mouse. |
| PubMed: | Nutritional and botanical interventions to assist with the adaptation to stress. |
| PubMed: | Pantethine. |
| PubMed: | Pantethine stimulates lipolysis in adipose tissue and inhibits cholesterol and fatty acid synthesis in liver and intestinal mucosa in the normolipidemic rat. |
| PubMed: | Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives. |
| PubMed: | Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme. |
| PubMed: | Loss of cytoskeletal proteins and lens cell opacification in the selenite cataract model. |
| PubMed: | Reduction of pantethine in rabbit ocular lens homogenate. |
| PubMed: | Modulation of the chaperone-like activity of bovine alpha-crystallin. |
| PubMed: | Pantethine inhibits the formation of high-Tc protein aggregates in gamma B crystallin solutions. |
| PubMed: | Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate hypercholesterolemia. |
| PubMed: | Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin. |
| PubMed: | Delay or inhibition of rat lens opacification using pantethine and WR-77913. |
| PubMed: | Effect of selected anti-cataract agents on opacification in the selenite cataract model. |
| PubMed: | Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation. |
| PubMed: | Inhibition of lens opacification during the early stages of cataract formation. |
| PubMed: | A kinetic study on pantetheinase inhibition by disulfides. |
| PubMed: | [Possible ways of regulating detoxifying processes in the alcohol dehydrogenase reaction with pantothenic acid derivatives]. |
| PubMed: | Effects of pantethine on lipogenesis and CO2 production in the isolated hepatocytes of the chick (Gallus domesticus). |
| PubMed: | [Study of pantothenic acid derivatives as cardiac protectors in a model of experimental ischemia and reperfusion of the isolated heart]. |
| PubMed: | [Comparison of the efficacy of pantethine, acipimox, and bezafibrate on plasma lipids and index of cardiovascular risk in diabetics with dyslipidemia]. |
| PubMed: | [Regulation of superoxide dismutase activity during deep hypothermia by simultaneous administration of water and lipid soluble antioxidants]. |
| PubMed: | [Effects of pantethine on metabolism in myocardial mitochondria under the conditions of deep hypothermia]. |
| PubMed: | Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate. |
| PubMed: | [Effect of pantethine on post-heparin lipolytic activity and lipid peroxidation in the myocardium]. |
| PubMed: | Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. |
| PubMed: | Pharmacologic and surgical treatment of dyslipidemic children and adolescents. |
| PubMed: | [Purification and various properties of pantothenate kinase from the rat liver]. |
| PubMed: | [Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age]. |
| PubMed: | Comparative studies of intracerebroventricularly administered cysteamine and pantethine in different behavioral tests and on brain catecholamines in rats. |
| PubMed: | The depletion of plasma prolactin by pantethine in oestrogen-primed hyperprolactinaemic rats. |
| PubMed: | Protection by pantethine, pantothenic acid and cystamine against carbon tetrachloride-induced hepatotoxicity in the rat. |
| PubMed: | Changes in oxytocin and vasopressin content in posterior pituitary and hypothalamus following pantethine treatment. |
| PubMed: | Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system. |
| PubMed: | Dose- and time-response effects of pantethine on open-field behavior, and on central neurotransmission in rats. |
| PubMed: | [A double-blind clinical trial--the effects of pantethine on serum lipids in patients with hyperlipidemia]. |
| PubMed: | Effects of dietary pantethine levels on drug-metabolizing system in the liver of rats orally administered varying amounts of autoxidized linoleate. |
| PubMed: | Effects of pantethine, cysteamine and pantothenic acid on open-field behavior and brain catecholamines in rats. |
| PubMed: | Pantethine, a somatostatin depleting agent, increases food intake in rats. |
| PubMed: | Investigation of the roles of the substances in serum lipids and their constitutive fatty acids in chronic urticaria. |
| PubMed: | Cysteamine and pantethine effects on passive avoidance behavior, shuttle box learning, open-field activity, striatal catecholamines and somatostatin. |
| PubMed: | [Pantethine, diabetes mellitus and atherosclerosis. Clinical study of 1045 patients]. |
| PubMed: | Effects of cysteamine and pantethine on open-field behavior, hypothalamic catecholamine concentrations, and somatostatin-induced barrel rotation in rats. |
| PubMed: | Modulation of HMG-CoA reductase activity by pantetheine/pantethine. |
| PubMed: | [The protective effect of pantothenic acid derivatives and changes in the system of acetyl CoA metabolism in acute ethanol poisoning]. |
| PubMed: | Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. |
| PubMed: | [Coa biosynthesis and the structure of its reserve in the liver in mice with diabetes (db/db) after administration of pantothenic acid derivatives]. |
| PubMed: | [Metabolism of pantothenic acid and its derivatives in animals deficient in this enzyme]. |
| PubMed: | [Thrombocytopenic purpura during treatment with pantethine]. |
| PubMed: | [Therapeutic efficacy of pantothenic acid preparations in ischemic heart disease patients]. |
| PubMed: | Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia. |
| PubMed: | [Various hormonal parameters (ACTH, cortisol, somatotropic hormone and prolactin) following administration of a single high dose of pantethine in healthy subjects]. |
| PubMed: | Effects of pantethine supplementation to diets with different energy cereals on hepatic lipogenesis of laying hens. |
| PubMed: | Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide formation in isolated rat hepatocytes. |
| PubMed: | [Atherosclerosis and prostaglandins: new biochemical frontiers of a more rational therapy]. |
| PubMed: | [Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia]. |
| PubMed: | Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. |
| PubMed: | Lipoprotein changes induced by pantethine in hyperlipoproteinemic patients: adults and children. |
| PubMed: | [Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes]. |
| PubMed: | [Studies on percutaneous absorption of pantethine in guinea pigs]. |
| PubMed: | Effect of probucol, pantethine and their combinations on serum lipoprotein metabolism and on the incidence of atheromatous lesions in the rabbit. |
| PubMed: | Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes. |
| PubMed: | [Effects of pantethine on blood lipids]. |
| PubMed: | Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial. |
| PubMed: | Enzymatic hydrolysis of pantetheine. |
| PubMed: | Activation and inhibition of yeast aldehyde dehydrogenase activity by pantethine and its metabolites. |
| PubMed: | Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. |
| PubMed: | [Clinico-therapeutic importance of pantethine against seborrheic states of the scalp]. |
| PubMed: | [Use of pantethine in dyslipidemia of chronic uremic patients under dialysis treatment]. |
| PubMed: | [Therapeutic use of a combination containing calcium, vitamins, pantethine and carnitine in convalescence states in childhood]. |
| PubMed: | Effects of pantethine on in-vitro peroxidation of low density lipoproteins. |
| PubMed: | Metabolism of pantethine in cystinosis. |
| PubMed: | Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. |
| PubMed: | [Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]. |
| PubMed: | [Effects of D(+)-bis-(N-pantothenyl-amidoethyl)-disulphur on the blood lipid profile and apoproteins A and B levels]. |
| PubMed: | [Effect of pantethine therapy in chronic uremic patients undergoing hemodialysis with type IV hyperlipoproteinemia]. |
| PubMed: | Lowering of blood acetaldehyde but not ethanol concentrations by pantethine following alcohol ingestion: different effects in flushing and nonflushing subjects. |
| PubMed: | Effects of pantethine on action potential of canine papillary muscle during hypoxic perfusion. |
| PubMed: | Pantetheine and pantethine esters with hypolipidemic nicotinic acid derivatives. |
| PubMed: | Macrophage activation with pantethine and pantetheine-4'-phosphate. |
| PubMed: | Therapy of cystinosis. |
| PubMed: | Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment. |
| PubMed: | The effects of pantethine on lipid and lipoprotein abnormalities in survivors of cerebral infarction. |
| PubMed: | Pantethine versus fenofibrate in the treatment of type II hyperlipoproteinemia. |
| PubMed: | Pharmacological study of a new hypolipidemic drug of prolonged activity, the tetraester of pantethine with 3-(3-pyridinemethoxycarbonyl)propionic acid. |
| PubMed: | [Effect of oral pantethine administration on blood acetaldehyde levels following alcohol ingestion]. |
| PubMed: | Pantethine reduces plasma cholesterol and the severity of arterial lesions in experimental hypercholesterolemic rabbits. |
| PubMed: | [Treatment of chronic hepatopathies with phosphorylcholine and pantethine]. |
| PubMed: | Pantethine and cystamine deplete cystine from cystinotic fibroblasts via efflux of cysteamine-cysteine mixed disulfide. |
| PubMed: | [Changes in the content of the thiol form of the acetylation coenzyme in the liver during administration of vitamin B3-active compounds to intact and locally irradiated animals]. |
| PubMed: | Effect of pantethine on post-heparin plasma lipolytic activities and adipose tissue lipoprotein lipase in rats. |
| PubMed: | Renal cell culture using autopsy material from children with cystinosis. |
| PubMed: | Pantethine and pantothenate effect on the CoA content of rat liver. |
| PubMed: | Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. |
| PubMed: | [Hyperlipidemia, diabetes and atherosclerosis: efficacy of treatment with pantethine]. |
| PubMed: | Positive inotropic and negative chronotropic effect of pantethine on isolated cardiac muscle of guinea-pigs. |
| PubMed: | Effect of pantethine on fatty acid oxidation in microvessels of rat brain. |
| PubMed: | Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria. |
| PubMed: | Coenzyme A in dog kidneys during hypothermic perfusion. |
| PubMed: | Pantethine depletes cystinotic fibroblasts of cystine. |
| PubMed: | [Clinical study of the lipotropic activity of the preparation Fosfolip]. |
| PubMed: | Purification and characterization of a Bacillus megaterium disulfide reductase specific for disulfides containing pantethine 4',4"-diphosphate. |
| PubMed: | Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. |
| PubMed: | Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange. |
| PubMed: | Reduction of beta-oxidation capacity of rat liver mitochondria by feeding orotic acid. |
| PubMed: | Effects of pantethine on different models of experimental hyperlipidemia in rodents: a comparison with clofibrate. |
| PubMed: | Effect of pantethine on myocardial pH reduced by partial occlusion of the coronary artery in dogs with special reference to the myocardial levels of adenosine triphosphate, creatine phosphate, and lactate. |
| PubMed: | Effect of pantethine on lipoprotein profiles and HDL subfractions in experimentally hypercholesterolemic rabbits. |
| PubMed: | Evidence that the coenzyme A requirement for avian fatty acid synthase is not for the termination reaction. |
| PubMed: | Studies in search of modifiers of the toxicity of mercurials and speculations on its biochemical mechanism. |
| PubMed: | [Relationship between ADCC effector cells and the combination therapy of pantethine and lecithin--a proposal for management of patients with HBsAg carrier state (author's transl)]. |
| PubMed: | Effects of some hypolipidemic drugs on biochemical values and on hepatic peroxisomal enzymes of normolipemic rat. |
| PubMed: | [Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)]. |
| PubMed: | The effect of pantethine, a precursor of coenzyme A, on bile acids and lipids in rats fed with a cholesterol diet. |
| PubMed: | Reversible inactivation of guanylate cyclase by mixed disulfide formation. |
| PubMed: | Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. |
| PubMed: | [Participation of cyclic nucleotides in the mechanism of regulation of the tissue pool of coenzyme A and the acetylizing capacity of rats]. |
| PubMed: | [Effect of pantethine on the lipoprotein abnormalities in survivors of cerebral infarction (author's transl)]. |
| PubMed: | Effect of pantethine on cholesterol ester metabolism in rat arterial wall. |
| PubMed: | [Study of enhancement of LCAT activity (author's transl)]. |
| PubMed: | [Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice]. |
| PubMed: | Identification of an NADH-linked disulfide reductase from Bacillus megaterium specific for disulfides containing pantethine 4',4''-diphosphate moieties. |
| PubMed: | [Studies on the prevention of side-effects by antituberculous drugs with special reference to effectiveness of pantethine (author's transl)]. |
| PubMed: | [Effects of caerulein on intestinal motility (author's transl)]. |
| PubMed: | Biosynthesis of sphingomyelin in rat liver endoplasmic reticulum. |
| PubMed: | Protective effect of pantethine on experimental thrombocytopenia in the rat. |
| PubMed: | [Medical treatment of male infertility. IV. Effect of pantethine on the seminal fluid in infertile patients]. |
| PubMed: | [Male adnexal organ secretion and enzymes. VI. Effects of pantethine on the enzyme level of seminal fluid in infertile patients]. |
| PubMed: | 13C NMR or coenzyme A and its constituent moieties. |
| PubMed: | Nutritional features of the intestinal anaerobe Ruminococcus bromii. |
| PubMed: | [Action of pantethine on the adrenal cortex of hypophysectomized rats]. |
| PubMed: | Studies on the metabolites in urine and feces of rat after oral administration of radioactive pantethine. |
| PubMed: | [Biological studies of pantethine. 10. Effects of anesthetics on gastrointestinal-motility promoting effect of pantethine]. |
| PubMed: | [Effects of pantethine on proliferation of intestinal bifidus bacteria in bottle-fed infants]. |
| PubMed: | The enzymatic breakdown of pantethine to pantothenic acid and cystamine. |
| PubMed: | [Effect of pantethine on the function of the adrenal cortex. 2. Clinical experience using pantethine in cases under steroid hormone treatment]. |
| PubMed: | [Biological studies of pantethine. 8. Effects of pantethine on estrous cycle and pregnancy in mice]. |
| PubMed: | [The influence of pantethine (PTSS), a derivative of pantothenic acid on experimentally injured liver in rabbits]. |
| PubMed: | [Effect of pantethine on the adrenocortical function. 1. Experimental results using rabbits]. |
| PubMed: | [Effects of pantethine on the reserve function of the adrenal cortex in nephrosis syndrome]. |
| PubMed: | Studies on the microbiological determination of pantethine. II. An improved basal medium for microbiological assay with Lactobacillus bulgaricus B-1 strain. |
| PubMed: | Studies on the microbiological determination of pantethine. I. Nutritional requirements of Lactobacillus bulgaricus B-1 strain. |
| PubMed: | A new method for the determination of enzymatic pantethine--splitting activity. |
| PubMed: | [Metabolism of drugs. LXVI. Studies on the metabolic fate of pantethine]. |
| PubMed: | Kipid metabolism in the rats with fatty liver caused by low protein diet and effects of the oral administration of L-methionine, L-cysteine, pantethine and calcium pantothenate upon it. |
| PubMed: | [Biological studies of pantethine. 7. Influence on the reproductive efficiency of mice]. |
| PubMed: | Investigations on pantothenic acid and its related compounds. XIV. Biochemical studies. (8). Effect of pantethine analogs on Lactobacillus bulgaricus B1. |
| PubMed: | Investigations on pantothenic acid and its related compounds. 13. Chemical studies. (6). Syntheses of homopantethine and some other pantethine analogs. |
| PubMed: | Action of SH-containing compounds and of plasma from pantethine treated rabbits on platelet counts in irradiated rats. |
| PubMed: | Urinary excretion of pantothenic acid and pantethine in human subjects. |
| PubMed: | Action of plasma from pantethine treated donors on platelet counts and hemorragic diathesis in thrombocytopenia. |
| PubMed: | Experimental studies on liver coenzyme A. 3. Effects of coenzyme A and pantethine upon liver coenzyme A and pantothenic acid contents of rats fed a pantothenic acid-deficient diet, or treated with carbon tetrachloride. |
| PubMed: | [CLINICAL EFFECTS OF PANTETHINE ON NEUROLOGICAL DISORDERS]. |
| PubMed: | Investigations on pantothenic acid and its related compounds. II. Biochemical studies. (1). Biosynthesis of coenzyme A from pantothenate, pantethine and from S-benzoylpantetheine in vitro and in vivo. |
| PubMed: | Investigations on pantothenic acid and its related compounds. I. Chemical studies. (1). A novel synthesis of pantethine. |
| PubMed: | [Enzymatic hydrolysis of pantethine]. |
| PubMed: | The reduction of pantethine by an extract of camel intestine. |
| PubMed: | PANTETHINE-REQUIRING BACTEROIDES. |
| PubMed: | [Histochemical aspects of the rat lung after treatment with prednisone and prednisone-pantethine]. |
| PubMed: | [Inhibition by pantethine of pulmonary hemorrhagic manifestations caused by prednisone. Experimental research in the rat]. |
| PubMed: | [In vitro effect of pantethine on the secretion of 21-C-corticosteroids by the ox adrenal]. |
| PubMed: | [Determination of pantethine in the presence of pantothenic acid]. |
| PubMed: | Propionic acid metabolism. II. Enzymatic synthesis of lactyl pantethine. |
| PubMed: | [The action of pantethine on the take of the homoplastic bone grafts]. |
| PubMed: | [Lipotropic & liver protective effect of pantethine in experimental liver diseases induced by Handler diet & carbon tetrachloride]. |
| PubMed: | [Effect of pantethine on Co60 distribution]. |
| PubMed: | [Effect of pantethine, vitamin B12 and ATP as growth factors on heart fibroblasts of chick embryo]. |
| PubMed: | [Initial clinical experiments with pantethine]. |
| PubMed: | [Pantethine]. |
| PubMed: | Phosphorylation of pantothenic acid and pantethine by an enzyme from Proteus morganii. |
| PubMed: | Pantethine and casein hydrolyzate in the growth of certain lactobacilli. |
| PubMed: | [Effect of pantothenic acid, pantethine and phosphorylated pantethine on carotene formation in Mucor hiemalis]. |
| PubMed: | Pantethine and related forms of the Lactobacillus bulgaricus factor (LBF). |
| PubMed: | The relationship of pantethine to naturally occurring forms of the Lactobacillus bulgaricus factor. |
| PubMed: | PANTETHINE, pantothenic acid and the Lactobacillus bulgaricus factor. |
| PubMed: | I. Activity of LBF (pantethine) in acetylation of sulfanilamide by pigeon liver extract. |
| PubMed: | The comparative activities of pantethine, pantothenic acid, and coenzyme A for various microorganisms. |
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