Articles:
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glycyrrhetinic acid hydrogen succinate, disodium salt
Notes:
an agent derived from licorice root. it is used for the treatment of digestive tract ulcers, especially in the stomach. antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.
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| CAS Number: | 7421-40-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 231-044-0 | |
| FDA UNII: | F1MP7242Z5 | |
| Nikkaji Web: | MFCD00079043 | |
| Molecular Weight: | 614.73049856 | |
| Formula: | C34 H48 Na2 O7 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: foam boosting, surfactant agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 687.40 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 413.00 °F. TCC ( 211.60 °C. ) (est) |
| logP (o/w): | 7.083 (est) |
| Soluble in: | |
| water, 0.0003503 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
skin conditioning surfactants surfactant - foam boosting |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Carbenoxolone disodium ≥98%
Odor: characteristic Use: The sodium salt form of Carbenoxolone, which has been found to be an anti-infl |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Carbenoxolone disodium ≥98% |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Carbenoxolone disodium salt ≥98% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-dog LD50 371 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979. intravenous-dog LD50 371 mg/kg CARDIAC: PULSE RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. oral-dog LD50 3900 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979. oral-human TDLo 120 mg/kg/6W VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Canadian Medical Association Journal. Vol. 117, Pg. 1155, 1977. intraperitoneal-mouse LD50 120 mg/kg "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. intravenous-mouse LD50 198 mg/kg "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. oral-rabbit LD50 2000 mg/kg "Symposium on Carbenoxolone Sodium," Robson, J.M., and F.M. Sullivan, eds., London, Butterworth, 1968Vol. -, Pg. 6, 1968. intraperitoneal-rat LD50 92 mg/kg Farmaco. Vol. 49, Pg. 281, 1994. oral-rat LD50 2450 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. | |
| Dermal Toxicity: | |
|
subcutaneous-dog LD50 1060 mg/kg BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. subcutaneous-rat LD50 1515 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 710, 1979. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | foam boosting, surfactant agents | ||
| Recommendation for disodium succinoyl glycyrrhetinate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for disodium succinoyl glycyrrhetinate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 23899 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0007421401 |
| RTECS: | RK0250000 for cas# 7421-40-1 |
References:
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 23899 |
| Pubchem (sid): | 134988008 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| carbenoxolone disodium | |
| carbenoxolone, disodium salt | |
| glycyrrhetinic acid hydrogen succinate, disodium salt |