Articles:
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benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
Notes:
a potent local anesthetic of the ester type used for surface and spinal anesthesia.
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American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): TCBNIP Tetracaine Base USP
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| CAS Number: | 94-24-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 202-316-6 | |
| FDA UNII: | 0619F35CGV | |
| Nikkaji Web: | J3.945D | |
| Beilstein Number: | 2216051 | |
| MDL: | MFCD00053787 | |
| XlogP3: | 3.70 (est) | |
| Molecular Weight: | 264.36868000 | |
| Formula: | C15 H24 N2 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 389.36 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 373.00 °F. TCC ( 189.30 °C. ) (est) |
| logP (o/w): | 3.510 |
| Soluble in: | |
| water, 201.4 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| American International Chemical, LLC. |
| Tetracaine Base USP |
| BOC Sciences |
| For experimental / research use only. |
| Tetracaine |
| Glentham Life Sciences |
| Tetracaine |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Tetracaine ≥98% (TLC) |
| TCI AMERICA |
| For experimental / research use only. |
| Tetracaine >98.0%(GC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
parenteral-frog LDLo 200 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 447, 1932. parenteral-man LDLo 1 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS Sammlung von Vergiftungsfaellen. Vol. 10, Pg. 5C, 1939. intraperitoneal-mouse LD50 20 mg/kg Russian Pharmacology and Toxicology Vol. 35, Pg. 114, 1972. intravenous-mouse LD50 6 mg/kg European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 10, Pg. 291, 1975. oral-mouse LD50 300 mg/kg Helvetica Physiologia et Pharmacologica Acta. Vol. 15, Pg. 55, 1957. intratracheal-rabbit LD50 6500 ug/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976. parenteral-rabbit LD50 33500 ug/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976. intravenous-rabbit LDLo 6 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 160, Pg. 53, 1931. intraperitoneal-rat LD50 33 mg/kg Klinische Wochenscrift. Vol. 31, Pg. 97, 1953. intratracheal-rat LD50 4 mg/kg Klinische Wochenscrift. Vol. 31, Pg. 97, 1953. intravenous-rat LD50 6 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 539, 1958. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 41500 ug/kg Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 215, 1957. subcutaneous-rabbit LDLo 20 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 160, Pg. 53, 1931. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for tetracaine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for tetracaine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5411 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-(dimethylamino)ethyl 4-(butylamino)benzoate | |
| Chemidplus: | 0000094246 |
| RTECS: | DG4725000 for cas# 94-24-6 |
References:
| 2-(dimethylamino)ethyl 4-(butylamino)benzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5411 |
| Pubchem (sid): | 134970961 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07526 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2922.49.3700 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| amethocaine | |
| anetain | |
| benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester | |
| 4- | butylamino-benzoic acid 2-dimethylamino-ethyl ester |
| 4-( | butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
| p-( | butylamino)benzoic acid, 2-(dimethylamino)ethyl ester |
| p- | butylaminobenzoyl-2-dimethylaminoethanol |
| contralgin | |
| dicaine | |
| dikain | |
| 2-( | dimethylamino)ethyl 4-(butylamino)benzoate |
| 2-( | dimethylamino)ethyl p-(butylamino)benzoate |
| fissucain | |
| intercain | |
| laudocaine | |
| medicaine | |
| meethobalm | |
| metraspray | |
| mucaesthin | |
| pontocaine | |
| rexocaine | |
| synera | |
| uromucaesthin |