sodium toluene sulfonate
sodium p-methylbenzenesulfonate
 
Notes:
None found
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CAS Number: 12068-03-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 235-088-1
FDA UNII: 2V179P6Q43
Nikkaji Web: J27.492E
Molecular Weight: 194.18515928
Formula: C7 H7 Na O3 S
NMR Predictor: Predict (works with chrome or firefox)
Category: hydrotrope, surfactant agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.930 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: hydrotropics
surfactants
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Suppliers:
Covalent Chemical
Sodium Toluene Sulfonate
Stepan Company
STEPANATE® STS-40
Stepan Company
STEPANATE® STS-90
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LDLo  10000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(8), Pg. 67, 1983.

oral-rat LDLo  12000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(8), Pg. 67, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: hydrotrope, surfactant agents
Recommendation for sodium toluene sulfonate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium toluene sulfonate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 12068-03-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3720192
National Institute of Allergy and Infectious Diseases: Data
 sodium;4-methylbenzenesulfonate
Chemidplus: 0000657841
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References:
 sodium;4-methylbenzenesulfonate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 12068-03-0
Pubchem (cid): 3720192
Pubchem (sid): 134977330
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 surfactants 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 benzenesulfonic acid, 4-methyl-, sodium salt
 benzenesulfonic acid, 4-methyl-, sodium salt (1:1)
 benzenesulfonic acid, methyl-, sodium salt
 cyclophil STS 70
 eltesol ST 34
 eltesol ST 90
4-methylbenzenesulfonic acid sodium salt
 methylbenzenesulfonic acid, sodium salt
 pilot STS 32
 sodium 4-methylbenzene-1-sulfonate
 sodium 4-methylbenzenesulfonate
 sodium p-methylbenzenesulfonate
 sodium p-toluenesulfonate
 sodium p-toluenesulphonate
 sodium p-tolyl sulfonate
 sodium p-tolyl sulphonate
 sodium paratoluene sulphonate
 sodium toluene-4-sulphonate
 sodium toluene-p-sulphonate
 sodium toluenesulphonate
 sodium tosylate
 sodium;4-methylbenzenesulfonate
 stepanate STS-40
 stepanate STS-90
 toluene-4-sulfonic acid sodium salt
4-toluenesulfonic acid sodium salt
p-toluenesulfonic acid sodium salt
p-toluenesulfonic acid, sodium salt
para-toluenesulfonic acid, sodium salt
ar-toluenesulfonic acid, sodium salt (8CI)
 tosylate, sodium
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Articles:
PubMed: Increased proliferation and differentiation of pre-osteoblasts MC3T3-E1 cells on nanostructured polypyrrole membrane under combined electrical and mechanical stimulation.
PubMed: Calcein release behavior from liposomal bilayer; influence of physicochemical/mechanical/structural properties of lipids.
PubMed: Novel functionalized fluorescent polymeric nanoparticles for immobilization of biomolecules.
PubMed: Direct detection of a sulfonate ester genotoxic impurity by atmospheric-pressure thermal desorption-extractive electrospray-mass spectrometry.
PubMed: Ion-induced stacking of photosensitizer molecules can remarkably affect the luminescence detection of singlet oxygen in Candida albicans cells.
PubMed: Supramolecular dynamics as origin for thermally induced insoluble-to-soluble-to-insoluble transitions of copolymers in water.
PubMed: Membrane fluidity and activity of membrane ATPases in human erythrocytes under the influence of polyhydroxylated fullerene.
PubMed: Vapour-liquid equilibrium relationship between toluene and mixed surfactants.
PubMed: Evaluation of complexation ability using a sensor electrode chip equipped with a wireless screening system.
PubMed: One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate.
PubMed: Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo.
PubMed: Reduction of dinitrotoluene sulfonates in TNT red water using nanoscale zerovalent iron particles.
PubMed: The interfacial interactions of Tb-doped silica nanoparticles with surfactants and phospholipids revealed through the fluorescent response.
PubMed: A Sensitive and Simple HPLC-UV Method for Trace Level Quantification of Ethyl p-Toluenesulfonate and Methyl p-Toluenesulfonate, Two Potential Genotoxins in Active Pharmaceutical Ingredients.
PubMed: Chromatographic characterization of hydrophilic interaction liquid chromatography stationary phases: hydrophilicity, charge effects, structural selectivity, and separation efficiency.
PubMed: Glucose oxidase-polypyrrole electrodes synthesized in p-toluenesulfonic acid and sodium p-toluenesulfonate.
PubMed: Rheo-SANS studies on shear-thickening/thinning in aqueous rodlike micellar solutions.
PubMed: Accessibility control on copper(II) complexes in mesostructured porous silica obtained by direct synthesis using bidentate organosilane ligands.
PubMed: A method for measuring mouse respiratory allergic reaction to low-dose chemical exposure to allergens: an environmental chemical of uncertain allergenicity, a typical contact allergen and a non-sensitizing irritant.
PubMed: Effect of ionic environment on the rheology of wormlike micelle solutions of mixtures of surfactants with opposite charge.
PubMed: Catanionic surfactant vesicles for electrostatic molecular sequestration and separation.
PubMed: Dechlorination of chloroacetanilide herbicides by plant growth regulator sodium bisulfite.
PubMed: 18-crown-6 as a class I organic modifier in MEKC.
PubMed: Shear rheology and porous media flow of wormlike micelle solutions formed by mixtures of surfactants of opposite charge.
PubMed: Comparison of protein quantification and extraction methods suitable for E. coli cultures.
PubMed: Effect of ionic surfactants on drainage and equilibrium thickness of emulsion films.
PubMed: Spontaneous polymerization at the air-water interface: a Brewster angle microscopy study.
PubMed: Stopped-flow kinetic studies of sphere-to-rod transitions of sodium alkyl sulfate micelles induced by hydrotropic salt.
PubMed: Comparison of physicochemical properties of new ionic liquids based on imidazolium, quaternary ammonium, and guanidinium cations.
PubMed: [Adsorption of toluene and naphthalene on Beijing soils and its influence factor].
PubMed: [Joint toxicity on multi-component mixtures of SDS and substituted aromatic compounds].
PubMed: Preparation of nano-tentacle polypyrrole with pseudo-molecular template for ATP incorporation.
PubMed: Microrheology of wormlike micellar fluids from the diffusion of colloidal probes.
PubMed: Tuning the structure of SDS micelles by substituted anilinium ions.
PubMed: Highly efficient capture and long-term encapsulation of dye by catanionic surfactant vesicles.
PubMed: Unraveling the relationship between macula densa cell volume and luminal solute concentration/osmolality.
PubMed: Electrosynthetically patterned conducting polymer films for investigation of neural signaling.
PubMed: Electronic spectral behavior of bromophenol blue in oil in water microemulsions stabilized by sodium dodecyl sulfate and n-butanol.
PubMed: Glucose encapsulation in catanionic vesicles and kinetic study of the entrapment/release processes in the sodium dodecyl benzene sulfonate/cetyltrimethylammonium tosylate/water system.
PubMed: Viscoelastic behavior of surfactant threadlike micellar solutions: effects of additives, 4.
PubMed: Two-photon absorption in aqueous micellar solutions.
PubMed: Modification of MTT assay conditions to examine the cytotoxic effects of amitraz on the human lymphoblastoid cell line, WIL2NS.
PubMed: Sorption enhancement of aromatic sulfonates onto an aminated hyper-cross-linked polymer.
PubMed: Removal of non-ionic organic pollutants from water via liquid-liquid extraction.
PubMed: [Effect of surfactant on the evaporation of BTEX from static water].
PubMed: Discrimination of nitroxyl and nitric oxide by water-soluble Mn(III) porphyrins.
PubMed: Influence of the hydrotrope structure on the physical chemical properties of polyoxide aqueous solutions.
PubMed: Cetylpyridinium tetrachlorozincate as standard for tenside titration. Analytical methods with 1,3-dibromo-5,5-dimethylhydantoin (DBH) in respect to environmental and economical concern, part 19.
PubMed: PLURONIC x TETRONIC polyols: study of their properties and performance in the destabilization of emulsions formed in the petroleum industry.
PubMed: Intrinsic and acquired resistance to quaternary ammonium compounds in food-related Pseudomonas spp.
PubMed: Biodegradation of acetanilide herbicides acetochlor and butachlor in soil.
PubMed: Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles.
PubMed: Attenuating toluene mobility in loess soil modified with anion-cation surfactants.
PubMed: Properties and application of a partially purified alkaline xylanase from an alkalophilic fungus Aspergillus nidulans KK-99.
PubMed: The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin.
PubMed: Adsorption-desorption behavior of acetochlor to soils in the presence of some environmental substances.
PubMed: Immobilization of glucose oxidase in polypyrrole/polytetrahydrofuran graft copolymers.
PubMed: Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation.
PubMed: Efficacy of a new class of perfluoropolyethers in the prevention of irritant contact dermatitis.
PubMed: The determination of draining lymph node cell cytokine mRNA levels in BALB/c mice following dermal sodium lauryl sulfate, dinitrofluorobenzene, and toluene diisocyanate exposure.
PubMed: Examination of the Hydrotropic Effect of Sodium p-Toluenesulfonate on a Nonionic Surfactant (C(12)E(6)) Solution.
PubMed: Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application.
PubMed: Assessment of toxic potential of industrial chemicals using a cultured human bioartificial skin model: production of interleukin 1alpha and hydroxyeicosatetraenoic acids.
PubMed: Multicentre study for the development of an in vivo model to evaluate the influence of topical formulations on irritation.
PubMed: Development of a flow cytometry assay for the identification and differentiation of chemicals with the potential to elicit irritation, IgE-mediated, or T cell-mediated hypersensitivity responses.
PubMed: Perfluoropolyethers in the prevention of irritant contact dermatitis.
PubMed: The effect of chemical anti-inhibitors on fibrinolytic enzymes and inhibitors.
PubMed: Characterization of iridovirus IV1 polypeptides: mapping by surface labelling.
PubMed: Adherence of Borrelia burgdorferi to granulocytes of different animal species.
PubMed: Alkaline serine protease is an exotoxin of Vibrio alginolyticus in kuruma prawn, Penaeus japonicus.
PubMed: Petrolatum prevents irritation in a human cumulative exposure model in vivo.
PubMed: Enzymatic synthesis of S-adenosyl-L-methionine on the preparative scale.
PubMed: Irritant reactions on hairless micropig skin: a model for testing barrier creams?
PubMed: Simultaneous determination of L-693,612, a topical carbonic anhydrase inhibitor, and two potential metabolites in human whole blood by ion-pair high-performance liquid chromatography.
PubMed: Gel polymerization in detergents: conversion efficiency of methylene blue vs. persulfate catalysis, as investigated by capillary zone electrophoresis.
PubMed: Functional changes of dextran-modified alkaline proteinase from alkalophilic Bacillus sp.
PubMed: Efficacy of skin barrier creams (II). Ineffectiveness of a popular "skin protector" against various irritants in the repetitive irritation test in the guinea pig.
PubMed: Efficacy of skin barrier creams (I). The repetitive irritation test (RIT) in the guinea pig.
PubMed: Interaction of Bacillus subtilis spores with sodium hypochlorite, sodium dichloroisocyanurate and chloramine-T.
PubMed: Triorganotins inhibit the mitochondrial inner membrane anion channel.
PubMed: Effects of toluene on platelet membrane glycoprotein Ib and actin-binding protein.
PubMed: High in vitro spontaneous histamine release in long-term hemodialyzed patients.
PubMed: Percutaneous absorption of 4 organic solvents in the guinea pig (II). Effect of surfactants.
PubMed: Potentiation of angiostatic steroids by a synthetic inhibitor of arylsulfatase.
PubMed: Inactivation of the renal outer cortical brush-border membrane D-glucose transporter by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline.
PubMed: Carbodiimide-mediated O-sulfation of hydroxy-amino acids and peptides: a reaction suitable for radiolabeling.
PubMed: Histological assessment of skin damage by irritants: its possible use in the evaluation of a 'barrier cream'.
PubMed: [Hygienic regulation of sodium toluene sulfonate in reservoir water].
PubMed: Evidence for the functional association of enzyme I and HPr of the phosphoenolpyruvate-sugar phosphotransferase system with the membrane in sealed vesicles of Escherichia coli.
PubMed: GLC determination of bretylium in biological fluids.
PubMed: The use of p-toluene sulfonate to dissolve synaptosomal membrane proteins into organic solvents.
PubMed: Correlation between transformation potential and inducible enzyme levels of hamster embryo cells.
PubMed: The synthesis of cholesteryl alkyl ethers.
PubMed: Studies on the interaction between Escherichia coli pyruvate oxidase and a detergent activator by utilization of the fluorescence probe bis(8-p-toluidino-1-naphthalenesulfonate).
PubMed: Synthesis of iodine-131 labeled 6 beta-iodomethyl-19-norsitost-5(10)-en-3 beta-ol and 19-iodositost-5-en-3 beta-ol for adrenal imaging.
PubMed: Ligand-promoted transfer of proteins between phases: spontaneous and electrically helped.
PubMed: Arylsulfonate esters of fatty alcohols as hypocholesterolemic agents. I: Oleyl and linoleyl p-toluenesulfonates.
PubMed: Radiobromine labeled norcholesterol analogs. Synthesis and tissue distribution study in rats of bromine-82 labeled 6beta-bromomethyl-19-norcholest-5(10)-EN-38-OL.
PubMed: Quantitative analysis of proteins by the use of SDS-polyacrylamide-gel electrophoresis.
PubMed: Carbodimide coupling to formalin-fixed red blood cells. A direct passive hemagglutination test for anti-horse ferritin.
PubMed: Reactions of fluorescent probes with normal and chemically modified myelin.
PubMed: Detection of a possible precursor of immunoglobulin light chain in MOPC 41 A plasmacytoma cells.
PubMed: Complications in the simplest cellular enzyme assay: lysis of Escherichia coli for the assay of beta-galactosidase.
PubMed: The inhibition of human plasmin by human antithrombin-heparin cofactor.
PubMed: Formation of prethrombin-E, thrombin, and thrombin-E and their inhibition with antithrombin and enzyme inhibitors.
PubMed: Solubility and absorption spectra of complexes resulting from interaction among human albumin, bromcresol green and detergents.
PubMed: Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide.
PubMed: Digestion of fibrin by thrombin.
PubMed: The polypeptide composition of epidermal prekeratin.
PubMed: Nonhistone chromatin protein phosphorylation during azo-dye carcinogenesis.
PubMed: Effects of toluene and phenethyl alcohol on the ultrastructure of Escherichia coli.
PubMed: Large surface blebs on Escherichia coli heated to inactivating temperatures.
PubMed: Surface potential and energy-coupling in bioenergy-conserving membrane systems.
PubMed: Human fibrinogen heterogeneities. I. Structural and related studies of plasma fibrinogens which are high solubility catabolic intermediates.
PubMed: Tyrosyl-tRNA synthetase from baker's yeast. Isolation and some properties.
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