sodium tungstate
tungsten, diolatodioxo-, sodium salt (1:2)
 
Notes:
inactivates molybdoenzymes in anabaena.
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CAS Number: 13472-45-2Picture of molecule3D/inchi
Other(deleted CASRN): 44142-66-7
ECHA EINECS - REACH Pre-Reg: 236-743-4
FDA UNII: 64LRH4405G
MDL: MFCD00003505
Molecular Weight: 293.81633856
Formula: Na2 O4 W
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Allan Chemical
Sodium Tungstate 2H2O
American Elements
Sodium Tungstate 99%
Odor: characteristic
Use: Sodium Tungstate is generally immediately available in most volumes. Hydrate or anhydrous forms may be purchased. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LD50  139 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. Vol. 8, Pg. 51, 1967.

oral-guinea pig LD50  1152 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 10, 1966.

oral-mouse LD50  240 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 10, 1966.

intramuscular-rabbit LD50  105 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: FOOD INTAKE (ANIMAL)
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 301, 1949.

oral-rabbit LD50  875 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 10, 1966.

oral-rat LD50  1190 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(8), Pg. 10, 1966.

Dermal Toxicity:
subcutaneous-dog LDLo 140 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-guinea pig LDLo 810 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-rabbit LDLo 78 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-rat LD50 240 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for sodium tungstate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium tungstate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA Substance Registry Services (TSCA): 13472-45-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 26052
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 disodium;dioxido(dioxo)tungsten
Chemidplus: 0013472452
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References:
 disodium;dioxido(dioxo)tungsten
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 13472-45-2
Pubchem (cid): 26052
Pubchem (sid): 134991013
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
grades: technical; cp; crystalline dihydrate
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 disodium dioxido(dioxo)tungsten
 disodium tetraoxatungstate (2-)
 disodium tetraoxotungstate (2-)
 disodium tungstate (Na2WO4)
 disodium tungstate (VI)
 disodium wolframate
 disodium;dioxido(dioxo)tungsten
 sodium tetraoxotungstate(VI)
 sodium tungstate (Na2(WO4))
 sodium tungstate (Na2WO4)
 sodium tungstate anhydrous
 sodium tungstate(VI) (Na2WO4)
 sodium tungsten oxide
 sodium tungsten oxide (Na2WO4)
 sodium wolframate
 tungastate (WO4(2-)), disodium, (T-4)- (9CI)
 tungstate (WO42-), disodium, (T-4)-
 tungstate, sodium
 tungsten, diolatodioxo-, sodium salt (1:2)
 tungstic acid (H2WO4), disodium salt
 tungstic acid, disodium salt
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Articles:
PubMed: Subchronic Oral Toxicity of Sodium Tungstate in Sprague-Dawley Rats.
PubMed: Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants.
PubMed: Low molybdenum state induced by tungsten as a model of molybdenum deficiency in rats.
PubMed: Synthesis, structure and theoretical investigation into a homoleptic tris(dithiolene) tungsten.
PubMed: GFAAS determination of mercury in muscle samples of fish from Amazon, Brazil.
PubMed: Effects of sodium tungstate on oxidative stress enzymes in rats.
PubMed: Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers.
PubMed: Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition.
PubMed: Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.
PubMed: Proof-of-concept trial on the efficacy of sodium tungstate in human obesity.
PubMed: A functional leptin system is essential for sodium tungstate antiobesity action.
PubMed: Spinal reflexes in normal and sulfite oxidase deficient rats: effect of sulfite exposure.
PubMed: Beta cell protective effects of sodium tungstate in streptozotocin-induced diabetic rats: glycemic control, blockage of oxidative stress and beta cell histochemistry.
PubMed: A quantitative study of sodium tungstate protective effect on pancreatic beta cells in streptozotocin-induced diabetic rats.
PubMed: Study of tungstate-protein interaction in human serum by LC-ICP-MS and MALDI-TOF.
PubMed: Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
PubMed: Improved absorption of caseinophosphopeptide-bound iron: role of alkaline phosphatase.
PubMed: Oral administration of sodium tungstate improves cardiac performance in streptozotocin-induced diabetic rats.
PubMed: Influence of food and diabetes on pharmacokinetics of sodium tungstate in rat.
PubMed: Detection, quantitation, and identification of residual aminopenicillins by high-performance liquid chromatography after fluorescamine derivation.
PubMed: Determination of trichlormethiazide in bovine milk by high-performance liquid chromatography.
PubMed: Determination of lincomycin residue in salmon tissues by ion-pair reversed-phase liquid chromatography with electrochemical detection.
PubMed: Analysis of penicillin G in milk by liquid chromatography.
PubMed: Attempts to induce cytogenetic effects with sulphite in sulphite oxidase-deficient Chinese hamsters and mice.
PubMed: Ultraviolet spectrophotometric determination of benzoic acid in soy sauce.
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