Articles:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-
Notes:
a flavonol widely distributed in plants. it is an antioxidant, like many other phenolic heterocyclic compounds. glycosylated forms include rutin and quercetrin. Isol. from many plants, esp. fruits, such as Helichrysum, Euphorbia and Karwinskia spp. Present in the Solanaceae, Rhamnaceae, Passifloraceae and many other families. For example detected in almost all studied Umbelliferae. Nutriceutical with antiinflammatory props. and a positive influence on the blood lipid profile. Found in a wide variety of foodstuffs esp. apples, bee pollen, blackcurrants, capers, cocoa, cranberries, dock leaves, elderberries, fennel, lovage, red onions, ancho peppers, dill weed and tarragon
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 117-39-5 Quercetin 0.99 Quercetin isolated from the flower bud of Sophora flavescens Ait. It has protective effects against chronic mixed reflux esophagitis in rats (Rattus norvegicus) by inhibiting the NF-kappaB p65 and interleukin-8 signaling pathway. anti-HIV; anti-tumor; anti-cancer; antioxidant;
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): QUERCETIN ANHYDROUS 99.5%
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GP9232 Quercetin, anhydrous
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): HL0332 Quercetin 95%
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 17-20100 QUERCETIN ANHYDROUS
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| CAS Number: | 117-39-5 |  3D/inchi
|
| Other(deleted CASRN): | 73123-10-1 | |
| ECHA EINECS - REACH Pre-Reg: | 204-187-1 | |
| FDA UNII: | 9IKM0I5T1E | |
| Nikkaji Web: | J2.907F | |
| Beilstein Number: | 0317313 | |
| MDL: | MFCD00006828 | |
| XlogP3: | 1.50 (est) | |
| Molecular Weight: | 302.23910000 | |
| Formula: | C15 H10 O7 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: food additive and cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA/DG SANTE Petitions, Reviews, Notices: | |
| GRN 341 P17 | Quercetin View - notice PDF |
| GRN 341 P2 | Quercetin View - notice PDF |
| GRN 341 P3 | Quercetin View - notice PDF |
Physical Properties:
| Appearance: | yellow needles (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 316.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 642.00 to 643.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 479.00 °F. TCC ( 248.10 °C. ) (est) |
| logP (o/w): | 1.989 (est) |
| Soluble in: | |
| alcohol | |
| water, 60 mg/L @ 16C (exp) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antioxidants skin conditioning |
Suppliers:
| AIDP |
| Quercetin Dihydrate 95% |
| Alfa Biotechnology |
| For experimental / research use only. |
| Quercetin 98% |
| AuNutra® Industries |
| Quercetin P.E. |
| BASF |
| Diminish the skin’s “orange peel” appearance with Flavenger™ |
| BOC Sciences |
| For experimental / research use only. |
| Quercetin 0.99
Odor: characteristic Use: Quercetin isolated from the flower bud of Sophora flavescens Ait. It has protective effects against chronic mixed reflux esophagitis in rats (Rattus norvegicus) by inhibiting the NF-kappaB p65 and interleukin-8 signaling pathway.
anti-HIV; anti-tumor; anti-cancer; antioxidant; |
| Charkit Chemical |
| QUERCETIN ANHYDROUS 99.5% |
| Coompo |
| For experimental / research use only. |
| Quercetin from Plants ≥96%
Odor: characteristic Use: Quercetin exerts many beneficial health effects, including improvement of cardiovascular health, reducing risk for cancer, protection against osteoporosis. This phytochemical has anti-inflammatory, anti-allergic and antitoxic effects. Most of these properties are linked to its strong antioxidant action of quercetin but quercetin also modulates the expression of specific enzymes. Quercetin induces apoptosis and influences protein and lipid kinase signaling pathways. Quercetin is a candidate for preventing obesity-related diseases.
Quercetin may help to reduce symptoms of diabetes patients. One study showed that quercetin reduced blood glucose level and improved improved plasma insulin levels in streptozotocin-induced diabetic rats. An in-vitro study concluded that quercetin may have a pharmacological application in treating cardiovascular disease in diabetes mellitus patients.
Quercetin shows anti-inflammatory action by its direct antioxidant action and inhibition of inflammatory mediators and enzymes, such as lipoxygenase. Quercetin also inhibits the release of histamine, which causes congestion, by basophils and mast cells. Studies have shown an improved lung function and lower risk of certain respiratory diseases (asthma and bronchitis) for people with high apple (rich in quercetin) intake. Patients with increased levels of inflammation and oxidative stress might benefit most from a quercetin supplementation.
To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections and exercise-induced changes in immune function. Trained male cyclists were randomized to quercetin or placebo groups and, under double-blind procedures, received 3 weeks quercetin (1000 mg a day) or placebo before, during, and for 2 weeks after a 3-d period in which subjects cycled for 3 hours a day at approximately 57% Wmax. Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced upper respiratory tract infection incidence in cyclists during the 2-wk period after intensified exercise.
Studies demonstrate that flavonoid-rich diets protect against myocardial infarction and stroke. As many other flavonoids, quercetin inhibits oxidation of LDL (bad) cholesterol, lowers blood pressure and reduces the risk of heart disease.
Studies have shown that quercetin reduces cancer risk of prostate, ovary, breast, gastric and colon cells. Numerous in-vitro studies show that quercetin induces apoptosis of cancer cells through different mechanisms.
Preliminary studies indicate that quercetin my inhibit the proliferation of androgen- independent human prostatic tumor cells. In rats, in combination with finasteride, it reduces prostate weight. Whether therapy alone benefits those with benign prostate hyperplasia is not clearly known at this time. Many flavonoids act as aromatase inhibitors.
Quercetin supplementation has been linked with improved performance, but supporting evidence is week and often conflicting. Scientists suggest that quercetin may aid performance through its anti-inflammatory properties or by stimulating the activity of mitochondria. |
| Glentham Life Sciences |
| Quercetin, anhydrous |
| Jiangyin Healthway |
| Quercetin 95% |
| New functional food ingredients |
| Maypro Industries |
| Quercetin |
| Penta International |
| QUERCETIN ANHYDROUS |
| Qingdao Dacon Trading |
| Quercetin |
| Shaanxi Y-Herb Biotechnology |
| Food Grade Herbal Extract Powder Quercetin Powder CAS 117-39-5 anti asthmatic |
| Shaanxi Y-Herb Biotechnology |
| Organic Quercetin Powder 98% Fruit Flower Anhydrous Sophora Japonica Extract |
| Sinoway Industrial |
| For experimental / research use only. |
| Quercetin |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 161 mg/kg Reviews of Environmental Contamination and Toxicology. Vol. 113, Pg. 47, 1990. intravenous-rabbit LD50 100 mg/kg FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 18, 1969. oral-mouse LD50 159 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. intravenous-mouse LD50 18 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02589 intraperitoneal-mouse LD50 3000 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 186, 1968. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 97 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | food additive and cosmetic agents | ||
| Recommendation for quercetin usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for quercetin flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 117-39-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5280343 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | |
| Chemidplus: | 0000117395 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | LK8750000 for cas# 117-39-5 |
References:
| 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 117-39-5 |
| Pubchem (cid): | 5280343 |
| Pubchem (sid): | 135269910 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00389 |
| HMDB (The Human Metabolome Database): | HMDB05794 |
| FooDB: | FDB011904 |
| YMDB (Yeast Metabolome Database): | YMDB01777 |
| FDA Listing of Food Additive Status: | View |
| FDA Color Additive Status List | View |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •supplied as capsules & tablets •glycosylated forms include rutin and quercetrin •intravenous soln in ethanol or dmso ... | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
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Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy- |
| C.I. natural red 1 | |
| C.I. natural yellow 10 | |
| cyanidelonon 1522 | |
| cyanidenolon 1522 | |
| 3-(3,4- | dichlorophenoxy)benzaldehyde |
| 2-(3,4- | dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one |
| 2-(3,4- | dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one |
| 2-(3,4- | dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one |
| 2-(3,4- | dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one |
| flavone, 3,4',5,5',7-pentahydroxy- | |
| natural yellow 10 | |
| 3,3',4,5,7- | pentahydroxyflavone |
| 3,3',4',5,7- | pentahydroxyflavone |
| 3,5,7,3',4'- | pentahydroxyflavone |
| quercetine | |
| sophoretin | |
| 3',4',5,7- | tetrahydroxyflavan-3-ol |
| 3,5,7- | trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-on |
| 3,5,7- | trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one |
| xanthaurine |