dazomet
dimethylformocarbothialdine
 
Notes:
fumigant for poultry litter & eggs to control salmonella.
  • BOC Sciences
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      Product(s):
      533-74-4 Dazomet 95%
       
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CAS Number: 533-74-4Picture of molecule3D/inchi
Other(deleted CASRN): 1135442-80-6
ECHA EINECS - REACH Pre-Reg: 208-576-7
FDA UNII: S7419CG4W5
Nikkaji Web: J52.302J
Beilstein Number: 0116039
MDL: MFCD00023809
XlogP3-AA: 1.30 (est)
Molecular Weight: 162.27870000
Formula: C5 H10 N2 S2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm (IAUFC):533-74-4 ; 3,5-DIMETHYL-1,3,5,2H-TETRAHYDROTHIADIAZINE-2-THIONE
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 106.00 °C. @ 760.00 mm Hg
Boiling Point: 222.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.100000 mmHg @ 25.00 °C. (est)
Flash Point: 191.00 °F. TCC ( 88.20 °C. ) (est)
logP (o/w): 1.400
Soluble in:
 water, 3000 mg/L @ 25 °C (exp)
 water, 1.936e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Dazomet 95%
Santa Cruz Biotechnology
For experimental / research use only.
Dazomet
Sigma-Aldrich
For experimental / research use only.
Dazomet PESTANAL®, analytical standard
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-dog LD50  47 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

intramuscular-dog LDLo  250 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

oral-guinea pig LD50  160 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

intraperitoneal-mouse LD50  98 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S327, 1992.

oral-mouse LD50  180 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

unreported-mouse LD50  650 mg/kg
"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 430, 1971.

intraperitoneal-rabbit LD50  127 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

oral-rabbit LD50  120 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

intraperitoneal-rat LD50  87 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

oral-rat LD50  320 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

Dermal Toxicity:
skin-mouse LD50 2400 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S327, 1992.

subcutaneous-mouse LD50 248 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S327, 1992.

skin-rabbit LD50 7000 mg/kg
Toxicology and Applied Pharmacology. Vol. 9, Pg. 521, 1966.

skin-rat LD50 2260 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S327, 1992.

subcutaneous-rat LD50 470 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S327, 1992.

Inhalation Toxicity:
inhalation-rat LC50 8400 mg/m3/4H
Pesticide Manual. Vol. 9, Pg. 225, 1991.

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Safety in Use Information:
Category: herbicides / pesticides
Recommendation for dazomet usage levels up to:
 not for fragrance use.
 
Recommendation for dazomet flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment of confirmatory data for the active substance dazomet
View page or View pdf
Reasoned opinion on the modification of the existing maximum residue levels (MRLs) for dazomet in several vegetables
View page or View pdf
Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
Review of the existing maximum residue levels for dazomet according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 533-74-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 10788
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 3,5-dimethyl-1,3,5-thiadiazinane-2-thione
Chemidplus: 0000533744
EPA/NOAA CAMEO: hazardous materials
RTECS: 533-74-4
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References:
 3,5-dimethyl-1,3,5-thiadiazinane-2-thione
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 533-74-4
Pubchem (cid): 10788
Pubchem (sid): 134977043
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C18457
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 basamid
 basamid G
 basamid P
 carbothialdin
 crag 85W
 crag nemacide
3,5-dimethyl-1,3,5-thiadiazinane-2-thione
3,5-dimethyl-2-thionotetrahydro-1,3,5-thiadiazine
 dimethylformocarbothialdine
3,5-dimethylperhydro-1,3,5-thiadiazin-2-thion
3,5-dimethyltetrahydro-1,3,5-2H-thiadiazine-2-thione
3,5-dimethyltetrahydro-1,3,5-thiadiazine-2-thione
3,5-dimethyltetrahydro-2H-1,3,5-thiadiazine-2-thione
 DMTT
 fennosan B 100
 mylon
 mylone 85
 nalcon 243
 nefusan
 prezervit
 stauffer N 521
 tetrahydro-2H-3,5-dimethyl-1,3,5-thiadiazine-2-thione
 tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione
2-thio-3,5-dimethyltetrahydro-1,3,5-thiadiazine
 tiazon
 troysan 142
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Articles:
PubMed: Synergistic effect of Dazomet soil fumigation and Clonostachys rosea against cucumber Fusarium wilt.
PubMed: Evaluation of the combination of dimethyl disulfide and dazomet as an efficient methyl bromide alternative for cucumber production in China.
PubMed: Effect of biofumigation and chemical fumigation on soil microbial community structure and control of pepper Phytophthora blight.
PubMed: Effect of Nanoencapsulated Vitamin B1 Derivative on Inhibition of Both Mycelial Growth and Spore Germination of Fusarium oxysporum f. sp. raphani.
PubMed: Switchable skin window induced by optical clearing method for dermal blood flow imaging.
PubMed: Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging.
PubMed: Evaluation of dazomet as fumigant for the control of brown root rot disease.
PubMed: Allergic contact dermatitis due to dazomet absorbed by agricultural rubber boots.
PubMed: [Toxicity and bioactivity of several alternative nematocides against Ditylenchus destructor].
PubMed: Evaluation of the combination of 1,3-dichloropropene and dazomet as an efficient alternative to methyl bromide for cucumber production in China.
PubMed: Control of subterranean termites (Isoptera: Rhinotermitidae) infesting power poles.
PubMed: Recent studies of measures to improve basamid soil disinfestation.
PubMed: Changes in microorganisms populations in the soil after fumigation.
PubMed: Imaging dermal blood flow through the intact rat skin with an optical clearing method.
PubMed: Dose response assessment for effects of acute exposure to methyl isothiocyanate (MITC).
PubMed: Synergistic effect of ultrasound and thiazone-PEG 400 on human skin optical clearing in vivo.
PubMed: Combinations of soil fumigants for methyl-bromide replacement.
PubMed: Combinations of reduced rates of 1,3-dichloropropene and dazomet as a broad spectrum soil fumigation strategy in view of methyl bromide replacement.
PubMed: Pesticide-related dermatitis in Saku district, Japan, 1975-2000.
PubMed: Protein-enhanced decarboxylation of the covalent intermediate in benzoylformate decarboxylase--Desolvation or acid catalysis?
PubMed: Synthesis and application of amberlite XAD-2 functionalized with dithizone for field preconcentration and separation of trace cadmium in seawater.
PubMed: Fumigant distribution in forest nursery soils under water seal and plastic film after application of dazomet, metam-sodium and chloropicrin.
PubMed: Determination of dithiocarbamates and metabolites in plants by liquid chromatography-mass spectrometry.
PubMed: Evaluation of chemical and integrated strategies as alternatives to methyl bromide for the control of root-knot nematodes in Greece.
PubMed: Control of Pratylenchus vulnus in stone fruit nurseries.
PubMed: Chemical alternatives to methyl bromide for the control of root-knot nematodes in greenhouses.
PubMed: In vivo studies on genotoxicity of a soil fumigant, dazomet.
PubMed: S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors.
PubMed: Contact dermatitis due to Metasol D3T in a Jay cushion.
PubMed: Management of Plant-parasitic Nematodes with a Chitin-Urea Soil Amendment and Other Materials.
PubMed: Allergic contact dermatitis from dazomet.
PubMed: [The effect of thiazon on helminth eggs in soil].
PubMed: [Epicutaneous testing with plant protective and pest control agents (pesticides)].
PubMed: [Helminth removal from sewage sediment with thiazone].
PubMed: The effect of dazomet on salmonellas on artificially contaminated eggs.
PubMed: Use of dazomet as a poultry litter fumigant for salmonellas.
PubMed: Effects of D-D, telone or dazomet applied to potato ridges in spring on potato cyst-nematode, Heterodera rostochiensis, in sandy loam and silt loam soils.
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